1Q0L
Crystal structure of DXR in complex with fosmidomycin
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Chains | Domain Info | Class | Fold | Superfamily | Family | Domain | Species | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | d1q0la1 | All alpha proteins | Left-handed superhelix | 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain | 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain | 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain | (Escherichia coli ) [TaxId: 562 ], | SCOPe (2.08) |
A | d1q0la2 | Alpha and beta proteins (a/b) | NAD(P)-binding Rossmann-fold domains | NAD(P)-binding Rossmann-fold domains | Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain | 1-deoxy-D-xylulose-5-phosphate reductoisomerase | (Escherichia coli ) [TaxId: 562 ], | SCOPe (2.08) |
A | d1q0la3 | Alpha and beta proteins (a+b) | FwdE/GAPDH domain-like | Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | Dihydrodipicolinate reductase-like | 1-deoxy-D-xylulose-5-phosphate reductoisomerase | (Escherichia coli ) [TaxId: 562 ], | SCOPe (2.08) |
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | DXPR_C | e1q0lA1 | A: alpha superhelices | X: 1-deoxy-D-xylulose-5-phosphate reductoisomerase-C (From Topology) | H: 1-deoxy-D-xylulose-5-phosphate reductoisomerase-C (From Topology) | T: 1-deoxy-D-xylulose-5-phosphate reductoisomerase-C | F: DXPR_C | ECOD (1.6) |
A | DXP_redisom_C | e1q0lA3 | A: a+b two layers | X: FwdE/GAPDH domain-like | H: Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain (From Topology) | T: Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | F: DXP_redisom_C | ECOD (1.6) |
A | DXP_reductoisom | e1q0lA2 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: NAD(P)-binding Rossmann-fold domains | F: DXP_reductoisom | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A | 3.40.50.720 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | NAD(P)-binding Rossmann-like Domain | CATH (4.3.0) |
A | 1.10.1740.10 | Mainly Alpha | Orthogonal Bundle | Rna Polymerase Sigma Factor | Chain: A | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF02670 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXP_reductoisom) | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | - | Family | |
PF13288 | DXP reductoisomerase C-terminal domain (DXPR_C) | DXP reductoisomerase C-terminal domain | This is the C-terminal domain of the 1-deoxy-D-xylulose-5-phosphate reductoisomerase enzyme. This domain forms a left handed super-helix. | Domain | |
PF08436 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal domain (DXP_redisom_C) | 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal domain | This domain is found to the C-terminus of Pfam:PF02670 domains in bacterial and plant 1-deoxy-D-xylulose 5-phosphate reductoisomerases which catalyse the formation of 2-C-methyl-D-erythritol 4-phosphate from 1-deoxy-D-xylulose-5-phosphate in the pres ... | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR026877 | DXP reductoisomerase, C-terminal domain | Domain | |
IPR003821 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | Family | |
IPR036169 | DXP reductoisomerase, C-terminal domain superfamily | Homologous Superfamily | |
IPR013644 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, C-terminal | Domain | |
IPR036291 | NAD(P)-binding domain superfamily | Homologous Superfamily | |
IPR013512 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, N-terminal | Domain |