Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2 FamilyPoly(A) polymerase, PAP, middle domain 8026121 4002194 SCOP2 (2022-06-29)
ASCOP2 FamilyPoly(A) polymerase, PAP, C-terminal domain 8026122 4001245 SCOP2 (2022-06-29)
ASCOP2 FamilyPoly(A) polymerase, PAP, N-terminal domain 8026123 4002163 SCOP2 (2022-06-29)
ASCOP2 SuperfamilyPAP/OAS1 substrate-binding domain-like 8038500 3000941 SCOP2 (2022-06-29)
ASCOP2 SuperfamilyPAP/Archaeal CCA-adding enzyme C-terminal domain-like 8038501 3001147 SCOP2 (2022-06-29)
ASCOP2 SuperfamilyNucleotidyltransferase-like 8038502 3000129 SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
APAP_central_2nde1q79A1 A: alpha arraysX: HhH/H2THH: SAM/DNA-glycosylaseT: PAP/OAS1 substrate-binding domainF: PAP_central_2ndECOD (1.6)
APAP_RNA-binde1q79A2 A: a+b two layersX: Alpha-beta plaitsH: PAP/Archaeal CCA-adding enzyme, C-terminal domain (From Topology)T: PAP/Archaeal CCA-adding enzyme, C-terminal domainF: PAP_RNA-bindECOD (1.6)
APAP_central_1ste1q79A3 A: a+b three layersX: Nucleotidyltransferase-likeH: Nucleotidyltransferase (From Topology)T: NucleotidyltransferaseF: PAP_central_1stECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.30.70.590 Alpha Beta 2-Layer Sandwich Alpha-Beta Plaits Poly(A) polymerase predicted RNA binding domainCATH (4.3.0)
A3.30.460.10 Alpha Beta 2-Layer Sandwich Beta Polymerase domain 2CATH (4.3.0)
A1.10.1410.10 Mainly Alpha Orthogonal Bundle Poly(a)-polymerase, middle domain CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF04926Poly(A) polymerase predicted RNA binding domain (PAP_RNA-bind)Poly(A) polymerase predicted RNA binding domainBased on its similarity structurally to the RNA recognition motif this domain is thought to be RNA binding [1].Domain
PF04928Poly(A) polymerase central domain (PAP_central)Poly(A) polymerase central domainIn eukaryotes, polyadenylation of pre-mRNA plays an essential role in the initiation step of protein synthesis, as well as in the export and stability of mRNAs. Poly(A) polymerase, the enzyme at the heart of the polyadenylation machinery, is a templa ...In eukaryotes, polyadenylation of pre-mRNA plays an essential role in the initiation step of protein synthesis, as well as in the export and stability of mRNAs. Poly(A) polymerase, the enzyme at the heart of the polyadenylation machinery, is a template-independent RNA polymerase which specifically incorporates ATP at the 3' end of mRNA [1]. This entry represents the central domain.
Domain
PF01909Nucleotidyltransferase domain (NTP_transf_2)Nucleotidyltransferase domainMembers of this family belong to a large family of nucleotidyltransferases [1]. This family includes kanamycin nucleotidyltransferase (KNTase) which is a plasmid-coded enzyme responsible for some types of bacterial resistance to aminoglycosides. KNTa ...Members of this family belong to a large family of nucleotidyltransferases [1]. This family includes kanamycin nucleotidyltransferase (KNTase) which is a plasmid-coded enzyme responsible for some types of bacterial resistance to aminoglycosides. KNTase in-activates antibiotics by catalysing the addition of a nucleotidyl group onto the drug.
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
Poly(A) polymerase alpha

Protein Modification Annotation

Modified Residue(s)
ChainResidue(s)Description
CSD Parent Component: CYS

RESIDAA0262

PSI-MOD :  L-cysteine sulfinic acid MOD:00267
CSO Parent Component: CYS

RESIDAA0262 , AA0205

PSI-MOD :  L-cysteine sulfinic acid MOD:00267 , L-cysteine sulfenic acid MOD:00210