Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyGlycosyl hydrolases family 6, cellulases 8043861 3001060 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyGlycosyl hydrolases family 6, cellulases 8043861 3001060 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AGlyco_hydro_6e1qk2A1 A: a/b barrelsX: TIM beta/alpha-barrelH: Cellulases (From Topology)T: CellulasesF: Glyco_hydro_6ECOD (1.6)
BGlyco_hydro_6e1qk2B1 A: a/b barrelsX: TIM beta/alpha-barrelH: Cellulases (From Topology)T: CellulasesF: Glyco_hydro_6ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.20.20.40 Alpha Beta Alpha-Beta Barrel TIM Barrel 1, 4-beta cellobiohydrolaseCATH (4.3.0)
B3.20.20.40 Alpha Beta Alpha-Beta Barrel TIM Barrel 1, 4-beta cellobiohydrolaseCATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B
PF01341Glycosyl hydrolases family 6 (Glyco_hydro_6)Glycosyl hydrolases family 6- Domain

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

ChainsEnzyme NameDescriptionCatalytic Residues
cellulose 1,4-beta-cellobiosidase (non-reducing end)  M-CSA #440

This enzyme belongs to Glycosidase family-6, more specifically the exoglucanase family, which requires polymer-chain ends for catalytic activity. It has an inverting mechanism (equatorial to axial conformation) and catalyses the hydrolysis of (1-->4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains.

Defined by 6 residues: TYR:B-85 [auth B-169]ARG:B-90 [auth B-174]ASP:B-91 [auth B-175]SER:B-97 [auth B-181]ASP:B-137 [auth B-221]ASP:B-317 [auth B-401]
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