1QO5

Fructose 1,6-bisphosphate Aldolase from Human Liver Tissue

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d1qo5b_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Aldolase	Class I aldolase	Fructose-1,6-bisphosphate aldolase	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d1qo5c_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Aldolase	Class I aldolase	Fructose-1,6-bisphosphate aldolase	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
F	d1qo5f_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Aldolase	Class I aldolase	Fructose-1,6-bisphosphate aldolase	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
G	d1qo5g_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Aldolase	Class I aldolase	Fructose-1,6-bisphosphate aldolase	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
H	d1qo5h_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Aldolase	Class I aldolase	Fructose-1,6-bisphosphate aldolase	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
I	d1qo5i_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Aldolase	Class I aldolase	Fructose-1,6-bisphosphate aldolase	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
L	d1qo5l_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Aldolase	Class I aldolase	Fructose-1,6-bisphosphate aldolase	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
O	d1qo5o_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Aldolase	Class I aldolase	Fructose-1,6-bisphosphate aldolase	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
R	d1qo5r_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Aldolase	Class I aldolase	Fructose-1,6-bisphosphate aldolase	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d1qo5a_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Aldolase	Class I aldolase	Fructose-1,6-bisphosphate aldolase	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d1qo5d_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Aldolase	Class I aldolase	Fructose-1,6-bisphosphate aldolase	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E	d1qo5e_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Aldolase	Class I aldolase	Fructose-1,6-bisphosphate aldolase	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
J	d1qo5j_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Aldolase	Class I aldolase	Fructose-1,6-bisphosphate aldolase	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
K	d1qo5k_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Aldolase	Class I aldolase	Fructose-1,6-bisphosphate aldolase	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
M	d1qo5m_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Aldolase	Class I aldolase	Fructose-1,6-bisphosphate aldolase	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
N	d1qo5n_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Aldolase	Class I aldolase	Fructose-1,6-bisphosphate aldolase	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
P	d1qo5p_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Aldolase	Class I aldolase	Fructose-1,6-bisphosphate aldolase	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
Q	d1qo5q_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Aldolase	Class I aldolase	Fructose-1,6-bisphosphate aldolase	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Aldolase	8043481	3000445	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Aldolase	8043481	3000445	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Aldolase	8043481	3000445	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Aldolase	8043481	3000445	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Aldolase	8043481	3000445	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	Aldolase	8043481	3000445	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	Aldolase	8043481	3000445	SCOP2B (2022-06-29)
O	SCOP2B Superfamily	Aldolase	8043481	3000445	SCOP2B (2022-06-29)
R	SCOP2B Superfamily	Aldolase	8043481	3000445	SCOP2B (2022-06-29)
A	SCOP2 Family	Class I aldolase	8031103	4003216	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Aldolase	8043481	3000445	SCOP2 (2022-06-29)
D	SCOP2B Superfamily	Aldolase	8043481	3000445	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Aldolase	8043481	3000445	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	Aldolase	8043481	3000445	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	Aldolase	8043481	3000445	SCOP2B (2022-06-29)
M	SCOP2B Superfamily	Aldolase	8043481	3000445	SCOP2B (2022-06-29)
N	SCOP2B Superfamily	Aldolase	8043481	3000445	SCOP2B (2022-06-29)
P	SCOP2B Superfamily	Aldolase	8043481	3000445	SCOP2B (2022-06-29)
Q	SCOP2B Superfamily	Aldolase	8043481	3000445	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	Glycolytic	e1qo5B1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Glycolytic	ECOD (1.6)
C	Glycolytic	e1qo5C1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Glycolytic	ECOD (1.6)
F	Glycolytic	e1qo5F1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Glycolytic	ECOD (1.6)
G	Glycolytic	e1qo5G1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Glycolytic	ECOD (1.6)
H	Glycolytic	e1qo5H1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Glycolytic	ECOD (1.6)
I	Glycolytic	e1qo5I1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Glycolytic	ECOD (1.6)
L	Glycolytic	e1qo5L1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Glycolytic	ECOD (1.6)
O	Glycolytic	e1qo5O1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Glycolytic	ECOD (1.6)
R	Glycolytic	e1qo5R1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Glycolytic	ECOD (1.6)
A	Glycolytic	e1qo5A1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Glycolytic	ECOD (1.6)
D	Glycolytic	e1qo5D1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Glycolytic	ECOD (1.6)
E	Glycolytic	e1qo5E1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Glycolytic	ECOD (1.6)
J	Glycolytic	e1qo5J1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Glycolytic	ECOD (1.6)
K	Glycolytic	e1qo5K1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Glycolytic	ECOD (1.6)
M	Glycolytic	e1qo5M1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Glycolytic	ECOD (1.6)
N	Glycolytic	e1qo5N1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Glycolytic	ECOD (1.6)
P	Glycolytic	e1qo5P1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Glycolytic	ECOD (1.6)
Q	Glycolytic	e1qo5Q1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Glycolytic	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
C	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
F	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
G	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
H	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
I	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
L	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
O	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
R	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
A	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
D	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
E	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
J	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
K	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
M	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
N	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
P	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
Q	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R	PF00274	Fructose-bisphosphate aldolase class-I (Glycolytic)	Fructose-bisphosphate aldolase class-I	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R	FRUCTOSE-BISPHOSPHATE ALDOLASE B	binding monosaccharide binding fructose binding carbohydrate binding small molecule binding cytoskeletal protein binding protein binding molecular adaptor activity fructose-bisphosphate aldolase activity lyase activity catalytic activity carbon-carbon lyase activity aldehyde-lyase activity fructose-1-phosphate aldolase activity binding monosaccharide binding fructose binding carbohydrate binding small molecule binding cytoskeletal protein binding protein binding molecular adaptor activity fructose-bisphosphate aldolase activity lyase activity catalytic activity carbon-carbon lyase activity aldehyde-lyase activity fructose-1-phosphate aldolase activity ATPase binding enzyme binding identical protein binding	ribonucleotide catabolic process pyridine nucleotide catabolic process oxoacid metabolic process carbohydrate catabolic process carbohydrate derivative metabolic process organophosphate catabolic process nucleoside phosphate catabolic process organic acid metabolic process nucleobase-containing compound metabolic process glycolytic process phosphate-containing compound metabolic process pyridine-containing compound metabolic process small molecule metabolic process purine ribonucleotide catabolic process ribonucleotide catabolic process pyridine nucleotide catabolic process oxoacid metabolic process carbohydrate catabolic process carbohydrate derivative metabolic process organophosphate catabolic process nucleoside phosphate catabolic process organic acid metabolic process nucleobase-containing compound metabolic process glycolytic process phosphate-containing compound metabolic process pyridine-containing compound metabolic process small molecule metabolic process purine ribonucleotide catabolic process phosphorus metabolic process pyridine nucleotide metabolic process nucleoside phosphate metabolic process nicotinamide nucleotide metabolic process pyruvate metabolic process purine nucleoside diphosphate metabolic process primary metabolic process purine-containing compound catabolic process nucleotide metabolic process nucleobase-containing compound catabolic process nucleoside diphosphate metabolic process purine nucleoside diphosphate catabolic process nucleoside diphosphate catabolic process metabolic process nucleoside triphosphate metabolic process monocarboxylic acid metabolic process purine ribonucleotide metabolic process pyridine-containing compound catabolic process ribose phosphate metabolic process catabolic process ATP metabolic process purine nucleotide metabolic process ribonucleotide metabolic process nucleobase-containing small molecule metabolic process purine ribonucleoside triphosphate metabolic process ribonucleoside diphosphate metabolic process ribonucleoside diphosphate catabolic process nucleotide catabolic process ribonucleoside triphosphate metabolic process purine nucleoside triphosphate metabolic process purine nucleotide catabolic process carbohydrate metabolic process carbohydrate derivative catabolic process ADP catabolic process carboxylic acid metabolic process generation of precursor metabolites and energy purine-containing compound metabolic process ADP metabolic process organophosphate metabolic process purine ribonucleoside diphosphate metabolic process cellular process purine ribonucleoside diphosphate catabolic process NADH oxidation NAD metabolic process NADH metabolic process proton-transporting V-type ATPase complex assembly cellular component organization cellular component biogenesis vacuolar proton-transporting V-type ATPase complex assembly cellular component assembly protein-containing complex organization proton-transporting two-sector ATPase complex assembly protein-containing complex assembly cellular component organization or biogenesis monosaccharide metabolic process hexose metabolic process fructose metabolic process fructose 1,6-bisphosphate metabolic process small molecule biosynthetic process carbohydrate biosynthetic process monosaccharide biosynthetic process gluconeogenesis hexose biosynthetic process biosynthetic process glucose metabolic process fructose catabolic process hexose catabolic process glyceraldehyde-3-phosphate metabolic process aldehyde metabolic process monosaccharide catabolic process small molecule catabolic process fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate regulation of amide metabolic process negative regulation of small molecule metabolic process regulation of cellular process negative regulation of biological process regulation of generation of precursor metabolites and energy regulation of primary metabolic process negative regulation of nucleotide metabolic process regulation of small molecule metabolic process regulation of phosphate metabolic process regulation of nucleotide metabolic process regulation of pentose-phosphate shunt pentose-phosphate shunt negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of carbohydrate catabolic process regulation of biological process negative regulation of metabolic process regulation of purine nucleotide metabolic process negative regulation of pentose-phosphate shunt regulation of phosphorus metabolic process regulation of metabolic process negative regulation of purine nucleotide metabolic process negative regulation of phosphate metabolic process glucose 6-phosphate metabolic process negative regulation of cellular process regulation of NADP metabolic process amide metabolic process regulation of carbohydrate metabolic process biological regulation regulation of catabolic process NADP metabolic process NADPH regeneration negative regulation of phosphorus metabolic process positive regulation of molecular function regulation of molecular function regulation of ATP-dependent activity positive regulation of ATP-dependent activity	extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure intracellular membraneless organelle intracellular organelle centrosome extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure intracellular membraneless organelle intracellular organelle centrosome microtubule organizing center cytoskeleton centriolar satellite membraneless organelle microtubule cytoskeleton cytoplasm cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R	IPR029768	Fructose-bisphosphate aldolase class-I active site	Conserved Site
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R	IPR013785	Aldolase-type TIM barrel	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R	IPR000741	Fructose-bisphosphate aldolase, class-I	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R	Pharos: P05062	hereditary fructose intolerance autoimmune hepatitis Hypoxia fructose-1,6-bisphosphatase deficiency pancreatic intraductal papillary-mucinous neoplasm drug-induced hepatitis inborn errors of metabolism lung cancer nephrosclerosis pituitary cancer Crohn disease gastric cancer intellectual disability malignant colon neoplasm pancreatic intraductal papillary-mucinous carcinoma hereditary fructose intolerance autoimmune hepatitis Hypoxia fructose-1,6-bisphosphatase deficiency pancreatic intraductal papillary-mucinous neoplasm drug-induced hepatitis inborn errors of metabolism lung cancer nephrosclerosis pituitary cancer Crohn disease gastric cancer intellectual disability malignant colon neoplasm pancreatic intraductal papillary-mucinous carcinoma ulcerative colitis cholestasis drug-induced liver injury gastric neoplasm hereditary diffuse gastric adenocarcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.