Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad1qpna1 Alpha and beta proteins (a/b) TIM beta/alpha-barrel Nicotinate/Quinolinate PRTase C-terminal domain-like NadC C-terminal domain-like Quinolinic acid phosphoribosyltransferase (Nicotinate-nucleotide pyrophosphorylase, NadC), C-terminal domain (Mycobacterium tuberculosis H37Rv ) [TaxId: 83332 ], SCOPe (2.08)
Ad1qpna2 Alpha and beta proteins (a+b) alpha/beta-Hammerhead Nicotinate/Quinolinate PRTase N-terminal domain-like NadC N-terminal domain-like Quinolinic acid phosphoribosyltransferase (Nicotinate-nucleotide pyrophosphorylase, NadC), N-terminal domain (Mycobacterium tuberculosis H37Rv ) [TaxId: 83332 ], SCOPe (2.08)
Bd1qpnb1 Alpha and beta proteins (a/b) TIM beta/alpha-barrel Nicotinate/Quinolinate PRTase C-terminal domain-like NadC C-terminal domain-like Quinolinic acid phosphoribosyltransferase (Nicotinate-nucleotide pyrophosphorylase, NadC), C-terminal domain (Mycobacterium tuberculosis H37Rv ) [TaxId: 83332 ], SCOPe (2.08)
Bd1qpnb2 Alpha and beta proteins (a+b) alpha/beta-Hammerhead Nicotinate/Quinolinate PRTase N-terminal domain-like NadC N-terminal domain-like Quinolinic acid phosphoribosyltransferase (Nicotinate-nucleotide pyrophosphorylase, NadC), N-terminal domain (Mycobacterium tuberculosis H37Rv ) [TaxId: 83332 ], SCOPe (2.08)
Cd1qpnc1 Alpha and beta proteins (a/b) TIM beta/alpha-barrel Nicotinate/Quinolinate PRTase C-terminal domain-like NadC C-terminal domain-like Quinolinic acid phosphoribosyltransferase (Nicotinate-nucleotide pyrophosphorylase, NadC), C-terminal domain (Mycobacterium tuberculosis H37Rv ) [TaxId: 83332 ], SCOPe (2.08)
Cd1qpnc2 Alpha and beta proteins (a+b) alpha/beta-Hammerhead Nicotinate/Quinolinate PRTase N-terminal domain-like NadC N-terminal domain-like Quinolinic acid phosphoribosyltransferase (Nicotinate-nucleotide pyrophosphorylase, NadC), N-terminal domain (Mycobacterium tuberculosis H37Rv ) [TaxId: 83332 ], SCOPe (2.08)
Dd1qpnd1 Alpha and beta proteins (a/b) TIM beta/alpha-barrel Nicotinate/Quinolinate PRTase C-terminal domain-like NadC C-terminal domain-like Quinolinic acid phosphoribosyltransferase (Nicotinate-nucleotide pyrophosphorylase, NadC), C-terminal domain (Mycobacterium tuberculosis H37Rv ) [TaxId: 83332 ], SCOPe (2.08)
Dd1qpnd2 Alpha and beta proteins (a+b) alpha/beta-Hammerhead Nicotinate/Quinolinate PRTase N-terminal domain-like NadC N-terminal domain-like Quinolinic acid phosphoribosyltransferase (Nicotinate-nucleotide pyrophosphorylase, NadC), N-terminal domain (Mycobacterium tuberculosis H37Rv ) [TaxId: 83332 ], SCOPe (2.08)
Ed1qpne1 Alpha and beta proteins (a/b) TIM beta/alpha-barrel Nicotinate/Quinolinate PRTase C-terminal domain-like NadC C-terminal domain-like Quinolinic acid phosphoribosyltransferase (Nicotinate-nucleotide pyrophosphorylase, NadC), C-terminal domain (Mycobacterium tuberculosis H37Rv ) [TaxId: 83332 ], SCOPe (2.08)
Ed1qpne2 Alpha and beta proteins (a+b) alpha/beta-Hammerhead Nicotinate/Quinolinate PRTase N-terminal domain-like NadC N-terminal domain-like Quinolinic acid phosphoribosyltransferase (Nicotinate-nucleotide pyrophosphorylase, NadC), N-terminal domain (Mycobacterium tuberculosis H37Rv ) [TaxId: 83332 ], SCOPe (2.08)
Fd1qpnf1 Alpha and beta proteins (a/b) TIM beta/alpha-barrel Nicotinate/Quinolinate PRTase C-terminal domain-like NadC C-terminal domain-like Quinolinic acid phosphoribosyltransferase (Nicotinate-nucleotide pyrophosphorylase, NadC), C-terminal domain (Mycobacterium tuberculosis H37Rv ) [TaxId: 83332 ], SCOPe (2.08)
Fd1qpnf2 Alpha and beta proteins (a+b) alpha/beta-Hammerhead Nicotinate/Quinolinate PRTase N-terminal domain-like NadC N-terminal domain-like Quinolinic acid phosphoribosyltransferase (Nicotinate-nucleotide pyrophosphorylase, NadC), N-terminal domain (Mycobacterium tuberculosis H37Rv ) [TaxId: 83332 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyNicotinate/Quinolinate PRTase N-terminal domain-like 8035013 3000867 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyNicotinate/Quinolinate PRTase C-terminal domain-like 8043826 3000603 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyNicotinate/Quinolinate PRTase N-terminal domain-like 8035013 3000867 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyNicotinate/Quinolinate PRTase C-terminal domain-like 8043826 3000603 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyNicotinate/Quinolinate PRTase C-terminal domain-like 8043826 3000603 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyNicotinate/Quinolinate PRTase N-terminal domain-like 8035013 3000867 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyNicotinate/Quinolinate PRTase N-terminal domain-like 8035013 3000867 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyNicotinate/Quinolinate PRTase C-terminal domain-like 8043826 3000603 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyNicotinate/Quinolinate PRTase C-terminal domain-like 8043826 3000603 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyNicotinate/Quinolinate PRTase N-terminal domain-like 8035013 3000867 SCOP2B (2022-06-29)
FSCOP2B SuperfamilyNicotinate/Quinolinate PRTase C-terminal domain-like 8043826 3000603 SCOP2B (2022-06-29)
FSCOP2B SuperfamilyNicotinate/Quinolinate PRTase N-terminal domain-like 8035013 3000867 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AQRPTase_Ne1qpnA1 A: a+b complex topologyX: alpha/beta-Hammerhead/Barrel-sandwich hybridH: alpha/beta-Hammerhead/Barrel-sandwich hybridT: Nicotinate/Quinolinate PRTase N-terminal domain-likeF: QRPTase_NECOD (1.6)
AQRPTase_Ce1qpnA2 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: QRPTase_CECOD (1.6)
BQRPTase_Ne1qpnB1 A: a+b complex topologyX: alpha/beta-Hammerhead/Barrel-sandwich hybridH: alpha/beta-Hammerhead/Barrel-sandwich hybridT: Nicotinate/Quinolinate PRTase N-terminal domain-likeF: QRPTase_NECOD (1.6)
BQRPTase_Ce1qpnB2 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: QRPTase_CECOD (1.6)
CQRPTase_Ne1qpnC1 A: a+b complex topologyX: alpha/beta-Hammerhead/Barrel-sandwich hybridH: alpha/beta-Hammerhead/Barrel-sandwich hybridT: Nicotinate/Quinolinate PRTase N-terminal domain-likeF: QRPTase_NECOD (1.6)
CQRPTase_Ce1qpnC2 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: QRPTase_CECOD (1.6)
DQRPTase_Ne1qpnD1 A: a+b complex topologyX: alpha/beta-Hammerhead/Barrel-sandwich hybridH: alpha/beta-Hammerhead/Barrel-sandwich hybridT: Nicotinate/Quinolinate PRTase N-terminal domain-likeF: QRPTase_NECOD (1.6)
DQRPTase_Ce1qpnD2 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: QRPTase_CECOD (1.6)
EQRPTase_Ne1qpnE1 A: a+b complex topologyX: alpha/beta-Hammerhead/Barrel-sandwich hybridH: alpha/beta-Hammerhead/Barrel-sandwich hybridT: Nicotinate/Quinolinate PRTase N-terminal domain-likeF: QRPTase_NECOD (1.6)
EQRPTase_Ce1qpnE2 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: QRPTase_CECOD (1.6)
FQRPTase_Ne1qpnF1 A: a+b complex topologyX: alpha/beta-Hammerhead/Barrel-sandwich hybridH: alpha/beta-Hammerhead/Barrel-sandwich hybridT: Nicotinate/Quinolinate PRTase N-terminal domain-likeF: QRPTase_NECOD (1.6)
FQRPTase_Ce1qpnF2 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: QRPTase_CECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B, C, D, E
PF02749Quinolinate phosphoribosyl transferase, N-terminal domain (QRPTase_N)Quinolinate phosphoribosyl transferase, N-terminal domainQuinolinate phosphoribosyl transferase (QPRTase) or nicotinate-nucleotide pyrophosphorylase EC:2.4.2.19 is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid with 5-phosphoribosyl ...Quinolinate phosphoribosyl transferase (QPRTase) or nicotinate-nucleotide pyrophosphorylase EC:2.4.2.19 is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid with 5-phosphoribosyl-1-pyrophosphate (PRPP) in the presence of Mg2+ to give rise to nicotinic acid mononucleotide (NaMN), pyrophosphate and carbon dioxide [1,2]. The QA substrate is bound between the C-terminal domain of one subunit, and the N-terminal domain of the other. The N-terminal domain has an alpha/beta hammerhead fold.
Domain
A, B, C, D, E
PF01729Quinolinate phosphoribosyl transferase, C-terminal domain (QRPTase_C)Quinolinate phosphoribosyl transferase, C-terminal domainQuinolinate phosphoribosyl transferase (QPRTase) or nicotinate-nucleotide pyrophosphorylase EC:2.4.2.19 is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid with 5-phosphoribosyl ...Quinolinate phosphoribosyl transferase (QPRTase) or nicotinate-nucleotide pyrophosphorylase EC:2.4.2.19 is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid with 5-phosphoribosyl-1-pyrophosphate (PRPP) in the presence of Mg2+ to give rise to nicotinic acid mononucleotide (NaMN), pyrophosphate and carbon dioxide [1,2]. The QA substrate is bound between the C-terminal domain of one subunit, and the N-terminal domain of the other. The C-terminal domain has a 7 beta-stranded TIM barrel-like fold.
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B, C, D, E
PROTEIN (QUINOLINATE PHOSPHORIBOSYL TRANSFERASE)