Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
C [auth A]d1r0aa1 Alpha and beta proteins (a/b) Ribonuclease H-like motif Ribonuclease H-like Ribonuclease H HIV RNase H (Domain of reverse transcriptase) (Human immunodeficiency virus 1 ) [TaxId: 11676 ], SCOPe (2.08)
C [auth A]d1r0aa2 Multi-domain proteins (alpha and beta) DNA/RNA polymerases DNA/RNA polymerases Reverse transcriptase HIV-1 reverse transcriptase (Human immunodeficiency virus 1 ) [TaxId: 11676 ], SCOPe (2.08)
D [auth B]d1r0ab1 Multi-domain proteins (alpha and beta) DNA/RNA polymerases DNA/RNA polymerases Reverse transcriptase HIV-1 reverse transcriptase (Human immunodeficiency virus 1 ) [TaxId: 11676 ], SCOPe (2.08)
E [auth L]d1r0al1 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin V set domains (antibody variable domain-like) Immunoglobulin light chain kappa variable domain, VL-kappa (Mus musculus ) [TaxId: 10090 ], SCOPe (2.08)
E [auth L]d1r0al2 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin C1 set domains (antibody constant domain-like) Immunoglobulin light chain kappa constant domain, CL-kappa (Mus musculus ) [TaxId: 10090 ], SCOPe (2.08)
F [auth H]d1r0ah1 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin V set domains (antibody variable domain-like) Immunoglobulin heavy chain variable domain, VH (Mus musculus ) [TaxId: 10090 ], SCOPe (2.08)
F [auth H]d1r0ah2 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin C1 set domains (antibody constant domain-like) Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma (Mus musculus ) [TaxId: 10090 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
C [auth A]SCOP2B SuperfamilyRibonuclease H-like 8075088 3000143 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
C [auth A]RVT_thumbe1r0aA7 A: alpha bundlesX: helical bundle domain in reverse transcriptase-like polymerases (From Topology)H: helical bundle domain in reverse transcriptase-like polymerases (From Topology)T: helical bundle domain in reverse transcriptase-like polymerasesF: RVT_thumbECOD (1.6)
C [auth A]RVT_1e1r0aA8 A: a+b two layersX: Alpha-beta plaitsH: Adenylyl and guanylyl cyclase catalytic domain-likeT: Adenylyl and guanylyl cyclase catalytic domain-likeF: RVT_1ECOD (1.6)
C [auth A]RNase_He1r0aA6 A: mixed a+b and a/bX: Ribonuclease H-likeH: Ribonuclease H-like (From Topology)T: Ribonuclease H-likeF: RNase_HECOD (1.6)
C [auth A]RVT_connecte1r0aA5 A: mixed a+b and a/bX: Ribonuclease H-likeH: RNaseH-like domain in reverse transcriptase (From Topology)T: RNaseH-like domain in reverse transcriptaseF: RVT_connectECOD (1.6)
D [auth B]RVT_thumbe1r0aB1 A: alpha bundlesX: helical bundle domain in reverse transcriptase-like polymerases (From Topology)H: helical bundle domain in reverse transcriptase-like polymerases (From Topology)T: helical bundle domain in reverse transcriptase-like polymerasesF: RVT_thumbECOD (1.6)
D [auth B]RVT_1e1r0aB2 A: a+b two layersX: Alpha-beta plaitsH: Adenylyl and guanylyl cyclase catalytic domain-likeT: Adenylyl and guanylyl cyclase catalytic domain-likeF: RVT_1ECOD (1.6)
D [auth B]RVT_connecte1r0aB3 A: mixed a+b and a/bX: Ribonuclease H-likeH: RNaseH-like domain in reverse transcriptase (From Topology)T: RNaseH-like domain in reverse transcriptaseF: RVT_connectECOD (1.6)
E [auth L]C1-set_4e1r0aL2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-set_4ECOD (1.6)
E [auth L]V-sete1r0aL1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-setECOD (1.6)
F [auth H]C1-set_1e1r0aH2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-set_1ECOD (1.6)
F [auth H]V-set_12e1r0aH1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-set_12ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

IMGT Antibody Annotation IMGT Database Homepage

ChainProtein NameDescriptionOrganism NameGene Allele Name(s)Domain Name(s)Receptor TypeReceptor DescriptionProvenance Source
E [auth L]Fab 28 L-KAPPA Mus musculus (house mouse) IGKV10-94*01, IGKJ1*01, IGKC*01, IGKC*02 V-DOMAIN V-KAPPA, C-DOMAIN C-KAPPA IG FAB-GAMMA-1_KAPPA IMGT (202443-0)
F [auth H]Fab 28 VH-CH1 Mus musculus (house mouse) IGHV8-12*01, IGHV8-5*01, IGHJ4*01, IGHG1*02 V-DOMAIN VH, C-DOMAIN CH1 IG FAB-GAMMA-1_KAPPA IMGT (202443-0)

SAbDab Antibody Annotation SAbDab Database Homepage

ChainChain ClassChain SubclassChain TypeAntigen Name(s) Provenance Source
E [auth L]Light ChainIGKV10 Kappareverse transcriptaseSAbDab (2024-11-01)
F [auth H]Heavy ChainIGHV8 -reverse transcriptaseSAbDab (2024-11-01)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
C [auth A]PF06817Reverse transcriptase thumb domain (RVT_thumb)Reverse transcriptase thumb domainThis domain is known as the thumb domain. It is composed of a four helix bundle [1].Domain
C [auth A]PF06815Reverse transcriptase connection domain (RVT_connect)Reverse transcriptase connection domainThis domain is known as the connection domain. This domain lies between the thumb and palm domains [1].Domain
C [auth A]PF00075RNase H (RNase_H)RNase HRNase H digests the RNA strand of an RNA/DNA hybrid. Important enzyme in retroviral replication cycle, and often found as a domain associated with reverse transcriptases. Structure is a mixed alpha+beta fold with three a/b/a layers.Domain
C [auth A]PF00078Reverse transcriptase (RNA-dependent DNA polymerase) (RVT_1)Reverse transcriptase (RNA-dependent DNA polymerase)A reverse transcriptase gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. Reverse transcriptases occur in a variety of mobile elements, including retrotransposons, retroviruses, group II introns, bacterial msDNAs ...A reverse transcriptase gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. Reverse transcriptases occur in a variety of mobile elements, including retrotransposons, retroviruses, group II introns, bacterial msDNAs, hepadnaviruses, and caulimoviruses.
Domain
D [auth B]PF06817Reverse transcriptase thumb domain (RVT_thumb)Reverse transcriptase thumb domainThis domain is known as the thumb domain. It is composed of a four helix bundle [1].Domain
D [auth B]PF06815Reverse transcriptase connection domain (RVT_connect)Reverse transcriptase connection domainThis domain is known as the connection domain. This domain lies between the thumb and palm domains [1].Domain
D [auth B]PF00078Reverse transcriptase (RNA-dependent DNA polymerase) (RVT_1)Reverse transcriptase (RNA-dependent DNA polymerase)A reverse transcriptase gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. Reverse transcriptases occur in a variety of mobile elements, including retrotransposons, retroviruses, group II introns, bacterial msDNAs ...A reverse transcriptase gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. Reverse transcriptases occur in a variety of mobile elements, including retrotransposons, retroviruses, group II introns, bacterial msDNAs, hepadnaviruses, and caulimoviruses.
Domain
F [auth H]PF07654Immunoglobulin C1-set domain (C1-set)Immunoglobulin C1-set domain- Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A [auth T]5'-D(*A*TP*GP*CP*AP*TP*CP*GP*GP*CP*GP*CP*TP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*GP*GP*T)-3'---
B [auth P]5'-D(*C*CP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*AP*GP*CP*GP*CP*CP*GP*(2DA))-3'---
C [auth A]Reverse transcriptase
D [auth B]Reverse transcriptase
E [auth L]monoclonal antibody (light chain)---
F [auth H]monoclonal antibody (heavy chain)

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
C [auth A]IPR036397Ribonuclease H superfamilyHomologous Superfamily
C [auth A]IPR043128Reverse transcriptase/Diguanylate cyclase domainHomologous Superfamily
C [auth A]IPR001995Peptidase A2A, retrovirus, catalyticDomain
C [auth A]IPR001878Zinc finger, CCHC-typeDomain
C [auth A]IPR008919Retrovirus capsid, N-terminalHomologous Superfamily
C [auth A]IPR012344Matrix protein, lentiviral and alpha-retroviral, N-terminalHomologous Superfamily
C [auth A]IPR036862Integrase, C-terminal domain superfamily, retroviralHomologous Superfamily
C [auth A]IPR018061RetropepsinsDomain
C [auth A]IPR010661Reverse transcriptase thumbDomain
C [auth A]IPR002156Ribonuclease H domainDomain
C [auth A]IPR036875Zinc finger, CCHC-type superfamilyHomologous Superfamily
C [auth A]IPR003308Integrase, N-terminal zinc-binding domainDomain
C [auth A]IPR001584Integrase, catalytic coreDomain
C [auth A]IPR045345Retroviral nucleocapsid Gag protein p24, C-terminal domainDomain
C [auth A]IPR010999Retroviral matrix proteinHomologous Superfamily
C [auth A]IPR021109Aspartic peptidase domain superfamilyHomologous Superfamily
C [auth A]IPR001969Aspartic peptidase, active siteActive Site
C [auth A]IPR012337Ribonuclease H-like superfamilyHomologous Superfamily
C [auth A]IPR017856Integrase-like, N-terminalHomologous Superfamily
C [auth A]IPR000071Immunodeficiency lentiviral matrix, N-terminalDomain
C [auth A]IPR043502DNA/RNA polymerase superfamilyHomologous Superfamily
C [auth A]IPR001037Integrase, C-terminal, retroviralDomain
C [auth A]IPR034170Retropepsin-like catalytic domainDomain
C [auth A]IPR000477Reverse transcriptase domainDomain
C [auth A]IPR010659Reverse transcriptase connectionDomain
C [auth A]IPR008916Retrovirus capsid, C-terminalHomologous Superfamily
D [auth B]IPR036397Ribonuclease H superfamilyHomologous Superfamily
D [auth B]IPR043128Reverse transcriptase/Diguanylate cyclase domainHomologous Superfamily
D [auth B]IPR001995Peptidase A2A, retrovirus, catalyticDomain
D [auth B]IPR001878Zinc finger, CCHC-typeDomain
D [auth B]IPR008919Retrovirus capsid, N-terminalHomologous Superfamily
D [auth B]IPR012344Matrix protein, lentiviral and alpha-retroviral, N-terminalHomologous Superfamily
D [auth B]IPR036862Integrase, C-terminal domain superfamily, retroviralHomologous Superfamily
D [auth B]IPR018061RetropepsinsDomain
D [auth B]IPR010661Reverse transcriptase thumbDomain
D [auth B]IPR002156Ribonuclease H domainDomain
D [auth B]IPR036875Zinc finger, CCHC-type superfamilyHomologous Superfamily
D [auth B]IPR003308Integrase, N-terminal zinc-binding domainDomain
D [auth B]IPR001584Integrase, catalytic coreDomain
D [auth B]IPR045345Retroviral nucleocapsid Gag protein p24, C-terminal domainDomain
D [auth B]IPR010999Retroviral matrix proteinHomologous Superfamily
D [auth B]IPR021109Aspartic peptidase domain superfamilyHomologous Superfamily
D [auth B]IPR001969Aspartic peptidase, active siteActive Site
D [auth B]IPR012337Ribonuclease H-like superfamilyHomologous Superfamily
D [auth B]IPR017856Integrase-like, N-terminalHomologous Superfamily
D [auth B]IPR000071Immunodeficiency lentiviral matrix, N-terminalDomain
D [auth B]IPR043502DNA/RNA polymerase superfamilyHomologous Superfamily
D [auth B]IPR001037Integrase, C-terminal, retroviralDomain
D [auth B]IPR034170Retropepsin-like catalytic domainDomain
D [auth B]IPR000477Reverse transcriptase domainDomain
D [auth B]IPR010659Reverse transcriptase connectionDomain
D [auth B]IPR008916Retrovirus capsid, C-terminalHomologous Superfamily
F [auth H]IPR036179Immunoglobulin-like domain superfamilyHomologous Superfamily
F [auth H]IPR050380Immune Recognition and Response ModulatorsFamily
F [auth H]IPR003597Immunoglobulin C1-setDomain
F [auth H]IPR013783Immunoglobulin-like foldHomologous Superfamily
F [auth H]IPR007110Immunoglobulin-like domainDomain