1R0A
Crystal structure of HIV-1 reverse transcriptase covalently tethered to DNA template-primer solved to 2.8 angstroms
External Resource: Annotation
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
C [auth A] | SCOP2B Superfamily | Ribonuclease H-like | 8075088 | 3000143 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
C [auth A] | RVT_thumb | e1r0aA7 | A: alpha bundles | X: helical bundle domain in reverse transcriptase-like polymerases (From Topology) | H: helical bundle domain in reverse transcriptase-like polymerases (From Topology) | T: helical bundle domain in reverse transcriptase-like polymerases | F: RVT_thumb | ECOD (1.6) |
C [auth A] | RVT_1 | e1r0aA8 | A: a+b two layers | X: Alpha-beta plaits | H: Adenylyl and guanylyl cyclase catalytic domain-like | T: Adenylyl and guanylyl cyclase catalytic domain-like | F: RVT_1 | ECOD (1.6) |
C [auth A] | RNase_H | e1r0aA6 | A: mixed a+b and a/b | X: Ribonuclease H-like | H: Ribonuclease H-like (From Topology) | T: Ribonuclease H-like | F: RNase_H | ECOD (1.6) |
C [auth A] | RVT_connect | e1r0aA5 | A: mixed a+b and a/b | X: Ribonuclease H-like | H: RNaseH-like domain in reverse transcriptase (From Topology) | T: RNaseH-like domain in reverse transcriptase | F: RVT_connect | ECOD (1.6) |
D [auth B] | RVT_thumb | e1r0aB1 | A: alpha bundles | X: helical bundle domain in reverse transcriptase-like polymerases (From Topology) | H: helical bundle domain in reverse transcriptase-like polymerases (From Topology) | T: helical bundle domain in reverse transcriptase-like polymerases | F: RVT_thumb | ECOD (1.6) |
D [auth B] | RVT_1 | e1r0aB2 | A: a+b two layers | X: Alpha-beta plaits | H: Adenylyl and guanylyl cyclase catalytic domain-like | T: Adenylyl and guanylyl cyclase catalytic domain-like | F: RVT_1 | ECOD (1.6) |
D [auth B] | RVT_connect | e1r0aB3 | A: mixed a+b and a/b | X: Ribonuclease H-like | H: RNaseH-like domain in reverse transcriptase (From Topology) | T: RNaseH-like domain in reverse transcriptase | F: RVT_connect | ECOD (1.6) |
E [auth L] | C1-set_4 | e1r0aL2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: C1-set_4 | ECOD (1.6) |
E [auth L] | V-set | e1r0aL1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: V-set | ECOD (1.6) |
F [auth H] | C1-set_1 | e1r0aH2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: C1-set_1 | ECOD (1.6) |
F [auth H] | V-set_12 | e1r0aH1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: V-set_12 | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
C [auth A] | 3.10.10.10 | Alpha Beta | Roll | HIV Type 1 Reverse Transcriptase | Chain A, domain 1 | CATH (4.3.0) |
C [auth A] | 3.30.70.270 | Alpha Beta | 2-Layer Sandwich | Alpha-Beta Plaits | Reverse transcriptase/Diguanylate cyclase domain | CATH (4.3.0) |
C [auth A] | 3.30.420.10 | Alpha Beta | 2-Layer Sandwich | Nucleotidyltransferase | domain 5 | CATH (4.3.0) |
D [auth B] | 3.10.10.10 | Alpha Beta | Roll | HIV Type 1 Reverse Transcriptase | Chain A, domain 1 | CATH (4.3.0) |
D [auth B] | 3.30.70.270 | Alpha Beta | 2-Layer Sandwich | Alpha-Beta Plaits | Reverse transcriptase/Diguanylate cyclase domain | CATH (4.3.0) |
E [auth L] | 2.60.40.10 | Mainly Beta | Sandwich | Immunoglobulin-like | Immunoglobulins | CATH (4.3.0) |
F [auth H] | 2.60.40.10 | Mainly Beta | Sandwich | Immunoglobulin-like | Immunoglobulins | CATH (4.3.0) |
IMGT Antibody Annotation IMGT Database Homepage
Chain | Protein Name | Description | Organism Name | Gene Allele Name(s) | Domain Name(s) | Receptor Type | Receptor Description | Provenance Source |
---|---|---|---|---|---|---|---|---|
E [auth L] | Fab 28 | L-KAPPA | Mus musculus (house mouse) | IGKV10-94*01, IGKJ1*01, IGKC*01, IGKC*02 | V-DOMAIN V-KAPPA, C-DOMAIN C-KAPPA | IG | FAB-GAMMA-1_KAPPA | IMGT (202443-0) |
F [auth H] | Fab 28 | VH-CH1 | Mus musculus (house mouse) | IGHV8-12*01, IGHV8-5*01, IGHJ4*01, IGHG1*02 | V-DOMAIN VH, C-DOMAIN CH1 | IG | FAB-GAMMA-1_KAPPA | IMGT (202443-0) |
SAbDab Antibody Annotation SAbDab Database Homepage
Chain | Chain Class | Chain Subclass | Chain Type | Antigen Name(s) | Provenance Source |
---|---|---|---|---|---|
E [auth L] | Light Chain | IGKV10 | Kappa | reverse transcriptase | SAbDab (2024-11-01) |
F [auth H] | Heavy Chain | IGHV8 | - | reverse transcriptase | SAbDab (2024-11-01) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
C [auth A] | PF06817 | Reverse transcriptase thumb domain (RVT_thumb) | Reverse transcriptase thumb domain | This domain is known as the thumb domain. It is composed of a four helix bundle [1]. | Domain |
C [auth A] | PF06815 | Reverse transcriptase connection domain (RVT_connect) | Reverse transcriptase connection domain | This domain is known as the connection domain. This domain lies between the thumb and palm domains [1]. | Domain |
C [auth A] | PF00075 | RNase H (RNase_H) | RNase H | RNase H digests the RNA strand of an RNA/DNA hybrid. Important enzyme in retroviral replication cycle, and often found as a domain associated with reverse transcriptases. Structure is a mixed alpha+beta fold with three a/b/a layers. | Domain |
C [auth A] | PF00078 | Reverse transcriptase (RNA-dependent DNA polymerase) (RVT_1) | Reverse transcriptase (RNA-dependent DNA polymerase) | A reverse transcriptase gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. Reverse transcriptases occur in a variety of mobile elements, including retrotransposons, retroviruses, group II introns, bacterial msDNAs ... | Domain |
D [auth B] | PF06817 | Reverse transcriptase thumb domain (RVT_thumb) | Reverse transcriptase thumb domain | This domain is known as the thumb domain. It is composed of a four helix bundle [1]. | Domain |
D [auth B] | PF06815 | Reverse transcriptase connection domain (RVT_connect) | Reverse transcriptase connection domain | This domain is known as the connection domain. This domain lies between the thumb and palm domains [1]. | Domain |
D [auth B] | PF00078 | Reverse transcriptase (RNA-dependent DNA polymerase) (RVT_1) | Reverse transcriptase (RNA-dependent DNA polymerase) | A reverse transcriptase gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. Reverse transcriptases occur in a variety of mobile elements, including retrotransposons, retroviruses, group II introns, bacterial msDNAs ... | Domain |
F [auth H] | PF07654 | Immunoglobulin C1-set domain (C1-set) | Immunoglobulin C1-set domain | - | Domain |