1RHC

F420-dependent secondary alcohol dehydrogenase in complex with an F420-acetone adduct

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Structure Motif: Primary M-CSA Annotation

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1rhca_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Bacterial luciferase-like	F420 dependent oxidoreductases	Coenzyme F420 dependent secondary alcohol dehydrogenase	(Methanoculleus thermophilus ) [TaxId: 2200 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	F420 dependent oxidoreductases	8028259	4003322	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Bacterial luciferase-like	8040638	3000585	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Bac_luciferase	e1rhcA1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Bac_luciferase	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.20.20.30	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Luciferase-like domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00296	Luciferase-like monooxygenase (Bac_luciferase)	Luciferase-like monooxygenase	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	F420-dependent alcohol dehydrogenase	oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen catalytic activity	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR050564	F420-dependent glucose-6-phosphate dehydrogenase/mer	Family
A	IPR011251	Luciferase-like domain	Domain
A	IPR019945	F420-dependent glucose-6-phosphate dehydrogenase-related	Family
A	IPR036661	Luciferase-like domain superfamily	Homologous Superfamily

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

Chains	Enzyme Name	Description	Catalytic Residues
A	secondary-alcohol dehydrogenase (coenzyme-F420) M-CSA #532	F420-dependent secondary alcohol dehydrogenase (Adf) from Methanoculleus thermophillicus is a member of the bacterial luciferase family. It catalyses the reduction of secondary alcohols no larger than isopentanol into their corresponding ketones, and is involved in the final process of anaerobic degradation of biomass.	Defined by 3 residues: HIS:A-39TRP:A-43GLU:A-108 \| Explore in 3D: M-CSA Motif Definition Search M-CSA Motif EC: 1.1.99 (PDB Primary Data) Search M-CSA Motif + EC 1.1.99

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.