Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad1ruva_ Alpha and beta proteins (a+b) RNase A-like RNase A-like Ribonuclease A-like Ribonuclease A (also ribonuclease B, S) (Bos taurus ) [TaxId: 9913 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyRNase A-like 8038165 3001918 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
ARnaseAe1ruvA1 A: a+b complex topologyX: RNase A-likeH: RNase A-like (From Topology)T: RNase A-likeF: RnaseAECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.10.130.10 Alpha Beta Roll P-30 Protein Ribonuclease A-like domainCATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF00074Pancreatic ribonuclease (RnaseA)Pancreatic ribonucleaseRibonucleases. Members include pancreatic RNAase A and angiogenins. Structure is an alpha+beta fold -- long curved beta sheet and three helices.Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

ChainsEnzyme NameDescriptionCatalytic Residues
ribonuclease 1  M-CSA #164

Ribonuclease-A (RNase-A) from Bos taurus catalyses the depolymerisation of RNA. It does this by breaking down the 3'-5' phosphodiester linkages of single stranded RNA. It is specific for pyrimidine bases at the 3' position of the phosphodiester bond that is cleaved, and a purine at the 5' end. RNase-A also shows a preference for polynucleotide substrates over oligonucleotides.

Defined by 5 residues: HIS:A-12LYS:A-41HIS:A-119PHE:A-120ASP:A-121
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Explore in 3DM-CSA Motif Definition