1SNN

3,4-dihydroxy-2-butanone 4-phosphate synthase from Methanococcus jannaschii

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Structure Motif: Primary M-CSA Annotation

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1snna_	Alpha and beta proteins (a+b)	YrdC/RibB	YrdC/RibB	3,4-dihydroxy-2-butanone 4-phosphate synthase, DHBP synthase, RibB	3,4-dihydroxy-2-butanone 4-phosphate synthase, DHBP synthase, RibB	(Methanocaldococcus jannaschii ) [TaxId: 2190 ],	SCOPe (2.08)
B	d1snnb_	Alpha and beta proteins (a+b)	YrdC/RibB	YrdC/RibB	3,4-dihydroxy-2-butanone 4-phosphate synthase, DHBP synthase, RibB	3,4-dihydroxy-2-butanone 4-phosphate synthase, DHBP synthase, RibB	(Methanocaldococcus jannaschii ) [TaxId: 2190 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	RibB-like	8089684	4000387	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	YrdC/RibB-like	8089685	3000166	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	YrdC/RibB-like	8089685	3000166	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	DHBP_synthase	e1snnA1	A: a+b complex topology	X: YrdC/RibB (From Topology)	H: YrdC/RibB (From Topology)	T: YrdC/RibB	F: DHBP_synthase	ECOD (1.6)
B	DHBP_synthase	e1snnB1	A: a+b complex topology	X: YrdC/RibB (From Topology)	H: YrdC/RibB (From Topology)	T: YrdC/RibB	F: DHBP_synthase	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.90.870.10	Alpha Beta	Alpha-Beta Complex	DHBP synthase	DHBP synthase	CATH (4.3.0)
B	3.90.870.10	Alpha Beta	Alpha-Beta Complex	DHBP synthase	DHBP synthase	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00926	3,4-dihydroxy-2-butanone 4-phosphate synthase (DHBP_synthase)	3,4-dihydroxy-2-butanone 4-phosphate synthase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	3,4-dihydroxy-2-butanone 4-phosphate synthase	cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding manganese ion binding transition metal ion binding lyase activity catalytic activity 3,4-dihydroxy-2-butanone-4-phosphate synthase activity carbon-carbon lyase activity	water-soluble vitamin biosynthetic process small molecule biosynthetic process flavin-containing compound metabolic process vitamin biosynthetic process riboflavin biosynthetic process vitamin metabolic process flavin-containing compound biosynthetic process biosynthetic process metabolic process cellular process small molecule metabolic process water-soluble vitamin metabolic process riboflavin metabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR017945	DHBP synthase RibB-like alpha/beta domain superfamily	Homologous Superfamily
A, B	IPR000422	3,4-dihydroxy-2-butanone 4-phosphate synthase, RibB	Family

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

Chains	Enzyme Name	Description	Catalytic Residues
A, B	3,4-dihydroxy-2-butanone-4-phosphate synthase M-CSA #648	L-3,4-Dihydroxy-2-butanone-4-phosphate synthase catalyses the conversion of ribulose 5-phosphate to L-3,4-dihydroxy-2-butanone-4-phosphate (DHBP) and formate in riboflavin biosynthesis. The proposed mechanism shares features with many enzymes, including the sugar isomerases.	Defined by 6 residues: ASP:A-30CYS:A-55TYR:A-95GLU:A-185ASN:B-106SER:B-147 \| Explore in 3D: M-CSA Motif Definition Search M-CSA Motif EC: 5.4.99 (PDB Primary Data) Search M-CSA Motif + EC 5.4.99 EC: 4.1.99.12 (UniProt) Search M-CSA Motif + EC 4.1.99.12

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.