Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
C [auth A]SCOP2B SuperfamilyRibonuclease H-like 8075088 3000143 SCOP2B (2022-06-29)
D [auth B]SCOP2B SuperfamilyNucleotide cyclase/DNA polymerase palm domain-like 8036908 3001272 SCOP2B (2022-06-29)
D [auth B]SCOP2B SuperfamilyNucleotide cyclase/DNA polymerase palm domain-like 8036908 3001272 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
C [auth A]RVT_thumbe1t05A1 A: alpha bundlesX: helical bundle domain in reverse transcriptase-like polymerases (From Topology)H: helical bundle domain in reverse transcriptase-like polymerases (From Topology)T: helical bundle domain in reverse transcriptase-like polymerasesF: RVT_thumbECOD (1.6)
C [auth A]RVT_1e1t05A2 A: a+b two layersX: Alpha-beta plaitsH: Adenylyl and guanylyl cyclase catalytic domain-likeT: Adenylyl and guanylyl cyclase catalytic domain-likeF: RVT_1ECOD (1.6)
C [auth A]RNase_He1t05A3 A: mixed a+b and a/bX: Ribonuclease H-likeH: Ribonuclease H-like (From Topology)T: Ribonuclease H-likeF: RNase_HECOD (1.6)
C [auth A]RVT_connecte1t05A4 A: mixed a+b and a/bX: Ribonuclease H-likeH: RNaseH-like domain in reverse transcriptase (From Topology)T: RNaseH-like domain in reverse transcriptaseF: RVT_connectECOD (1.6)
D [auth B]RVT_thumbe1t05B2 A: alpha bundlesX: helical bundle domain in reverse transcriptase-like polymerases (From Topology)H: helical bundle domain in reverse transcriptase-like polymerases (From Topology)T: helical bundle domain in reverse transcriptase-like polymerasesF: RVT_thumbECOD (1.6)
D [auth B]RVT_1e1t05B3 A: a+b two layersX: Alpha-beta plaitsH: Adenylyl and guanylyl cyclase catalytic domain-likeT: Adenylyl and guanylyl cyclase catalytic domain-likeF: RVT_1ECOD (1.6)
D [auth B]RVT_connecte1t05B1 A: mixed a+b and a/bX: Ribonuclease H-likeH: RNaseH-like domain in reverse transcriptase (From Topology)T: RNaseH-like domain in reverse transcriptaseF: RVT_connectECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
C [auth A]PF06817Reverse transcriptase thumb domain (RVT_thumb)Reverse transcriptase thumb domainThis domain is known as the thumb domain. It is composed of a four helix bundle [1].Domain
C [auth A]PF06815Reverse transcriptase connection domain (RVT_connect)Reverse transcriptase connection domainThis domain is known as the connection domain. This domain lies between the thumb and palm domains [1].Domain
C [auth A]PF00075RNase H (RNase_H)RNase HRNase H digests the RNA strand of an RNA/DNA hybrid. Important enzyme in retroviral replication cycle, and often found as a domain associated with reverse transcriptases. Structure is a mixed alpha+beta fold with three a/b/a layers.Domain
C [auth A]PF00078Reverse transcriptase (RNA-dependent DNA polymerase) (RVT_1)Reverse transcriptase (RNA-dependent DNA polymerase)A reverse transcriptase gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. Reverse transcriptases occur in a variety of mobile elements, including retrotransposons, retroviruses, group II introns, bacterial msDNAs ...A reverse transcriptase gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. Reverse transcriptases occur in a variety of mobile elements, including retrotransposons, retroviruses, group II introns, bacterial msDNAs, hepadnaviruses, and caulimoviruses.
Domain
D [auth B]PF06817Reverse transcriptase thumb domain (RVT_thumb)Reverse transcriptase thumb domainThis domain is known as the thumb domain. It is composed of a four helix bundle [1].Domain
D [auth B]PF06815Reverse transcriptase connection domain (RVT_connect)Reverse transcriptase connection domainThis domain is known as the connection domain. This domain lies between the thumb and palm domains [1].Domain
D [auth B]PF00078Reverse transcriptase (RNA-dependent DNA polymerase) (RVT_1)Reverse transcriptase (RNA-dependent DNA polymerase)A reverse transcriptase gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. Reverse transcriptases occur in a variety of mobile elements, including retrotransposons, retroviruses, group II introns, bacterial msDNAs ...A reverse transcriptase gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. Reverse transcriptases occur in a variety of mobile elements, including retrotransposons, retroviruses, group II introns, bacterial msDNAs, hepadnaviruses, and caulimoviruses.
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A [auth T]oligonucleotide template---
B [auth P]oligonucleotide primer---
C [auth A]POL polyprotein
D [auth B]POL polyprotein

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
C [auth A]IPR036397Ribonuclease H superfamilyHomologous Superfamily
C [auth A]IPR043128Reverse transcriptase/Diguanylate cyclase domainHomologous Superfamily
C [auth A]IPR001995Peptidase A2A, retrovirus, catalyticDomain
C [auth A]IPR001878Zinc finger, CCHC-typeDomain
C [auth A]IPR008919Retrovirus capsid, N-terminalHomologous Superfamily
C [auth A]IPR012344Matrix protein, lentiviral and alpha-retroviral, N-terminalHomologous Superfamily
C [auth A]IPR036862Integrase, C-terminal domain superfamily, retroviralHomologous Superfamily
C [auth A]IPR018061RetropepsinsDomain
C [auth A]IPR010661Reverse transcriptase thumbDomain
C [auth A]IPR002156Ribonuclease H domainDomain
C [auth A]IPR036875Zinc finger, CCHC-type superfamilyHomologous Superfamily
C [auth A]IPR003308Integrase, N-terminal zinc-binding domainDomain
C [auth A]IPR001584Integrase, catalytic coreDomain
C [auth A]IPR045345Retroviral nucleocapsid Gag protein p24, C-terminal domainDomain
C [auth A]IPR010999Retroviral matrix proteinHomologous Superfamily
C [auth A]IPR021109Aspartic peptidase domain superfamilyHomologous Superfamily
C [auth A]IPR001969Aspartic peptidase, active siteActive Site
C [auth A]IPR012337Ribonuclease H-like superfamilyHomologous Superfamily
C [auth A]IPR017856Integrase-like, N-terminalHomologous Superfamily
C [auth A]IPR000071Immunodeficiency lentiviral matrix, N-terminalDomain
C [auth A]IPR043502DNA/RNA polymerase superfamilyHomologous Superfamily
C [auth A]IPR001037Integrase, C-terminal, retroviralDomain
C [auth A]IPR034170Retropepsin-like catalytic domainDomain
C [auth A]IPR000477Reverse transcriptase domainDomain
C [auth A]IPR010659Reverse transcriptase connectionDomain
C [auth A]IPR008916Retrovirus capsid, C-terminalHomologous Superfamily
D [auth B]IPR036397Ribonuclease H superfamilyHomologous Superfamily
D [auth B]IPR043128Reverse transcriptase/Diguanylate cyclase domainHomologous Superfamily
D [auth B]IPR001995Peptidase A2A, retrovirus, catalyticDomain
D [auth B]IPR001878Zinc finger, CCHC-typeDomain
D [auth B]IPR008919Retrovirus capsid, N-terminalHomologous Superfamily
D [auth B]IPR012344Matrix protein, lentiviral and alpha-retroviral, N-terminalHomologous Superfamily
D [auth B]IPR036862Integrase, C-terminal domain superfamily, retroviralHomologous Superfamily
D [auth B]IPR018061RetropepsinsDomain
D [auth B]IPR010661Reverse transcriptase thumbDomain
D [auth B]IPR002156Ribonuclease H domainDomain
D [auth B]IPR036875Zinc finger, CCHC-type superfamilyHomologous Superfamily
D [auth B]IPR003308Integrase, N-terminal zinc-binding domainDomain
D [auth B]IPR001584Integrase, catalytic coreDomain
D [auth B]IPR045345Retroviral nucleocapsid Gag protein p24, C-terminal domainDomain
D [auth B]IPR010999Retroviral matrix proteinHomologous Superfamily
D [auth B]IPR021109Aspartic peptidase domain superfamilyHomologous Superfamily
D [auth B]IPR001969Aspartic peptidase, active siteActive Site
D [auth B]IPR012337Ribonuclease H-like superfamilyHomologous Superfamily
D [auth B]IPR017856Integrase-like, N-terminalHomologous Superfamily
D [auth B]IPR000071Immunodeficiency lentiviral matrix, N-terminalDomain
D [auth B]IPR043502DNA/RNA polymerase superfamilyHomologous Superfamily
D [auth B]IPR001037Integrase, C-terminal, retroviralDomain
D [auth B]IPR034170Retropepsin-like catalytic domainDomain
D [auth B]IPR000477Reverse transcriptase domainDomain
D [auth B]IPR010659Reverse transcriptase connectionDomain
D [auth B]IPR008916Retrovirus capsid, C-terminalHomologous Superfamily