1T5E

The structure of MexA

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
AMR Gene: CARD Annotation
AMR Gene Family: CARD Annotation
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: mpstruc

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
C	d1t5ec_	Membrane and cell surface proteins and peptides	HlyD-like secretion proteins	HlyD-like secretion proteins	HlyD-like secretion proteins	Multidrug resistance protein MexA domain	(Pseudomonas aeruginosa ) [TaxId: 287 ],	SCOPe (2.08)
D	d1t5ed_	Membrane and cell surface proteins and peptides	HlyD-like secretion proteins	HlyD-like secretion proteins	HlyD-like secretion proteins	Multidrug resistance protein MexA domain	(Pseudomonas aeruginosa ) [TaxId: 287 ],	SCOPe (2.08)
E	d1t5ee_	Membrane and cell surface proteins and peptides	HlyD-like secretion proteins	HlyD-like secretion proteins	HlyD-like secretion proteins	Multidrug resistance protein MexA domain	(Pseudomonas aeruginosa ) [TaxId: 287 ],	SCOPe (2.08)
G	d1t5eg_	Membrane and cell surface proteins and peptides	HlyD-like secretion proteins	HlyD-like secretion proteins	HlyD-like secretion proteins	Multidrug resistance protein MexA domain	(Pseudomonas aeruginosa ) [TaxId: 287 ],	SCOPe (2.08)
H	d1t5eh_	Membrane and cell surface proteins and peptides	HlyD-like secretion proteins	HlyD-like secretion proteins	HlyD-like secretion proteins	Multidrug resistance protein MexA domain	(Pseudomonas aeruginosa ) [TaxId: 287 ],	SCOPe (2.08)
I	d1t5ei_	Membrane and cell surface proteins and peptides	HlyD-like secretion proteins	HlyD-like secretion proteins	HlyD-like secretion proteins	Multidrug resistance protein MexA domain	(Pseudomonas aeruginosa ) [TaxId: 287 ],	SCOPe (2.08)
K	d1t5ek_	Membrane and cell surface proteins and peptides	HlyD-like secretion proteins	HlyD-like secretion proteins	HlyD-like secretion proteins	Multidrug resistance protein MexA domain	(Pseudomonas aeruginosa ) [TaxId: 287 ],	SCOPe (2.08)
L	d1t5el_	Membrane and cell surface proteins and peptides	HlyD-like secretion proteins	HlyD-like secretion proteins	HlyD-like secretion proteins	Multidrug resistance protein MexA domain	(Pseudomonas aeruginosa ) [TaxId: 287 ],	SCOPe (2.08)
M	d1t5em_	Membrane and cell surface proteins and peptides	HlyD-like secretion proteins	HlyD-like secretion proteins	HlyD-like secretion proteins	Multidrug resistance protein MexA domain	(Pseudomonas aeruginosa ) [TaxId: 287 ],	SCOPe (2.08)
A	d1t5ea_	Membrane and cell surface proteins and peptides	HlyD-like secretion proteins	HlyD-like secretion proteins	HlyD-like secretion proteins	Multidrug resistance protein MexA domain	(Pseudomonas aeruginosa ) [TaxId: 287 ],	SCOPe (2.08)
B	d1t5eb_	Membrane and cell surface proteins and peptides	HlyD-like secretion proteins	HlyD-like secretion proteins	HlyD-like secretion proteins	Multidrug resistance protein MexA domain	(Pseudomonas aeruginosa ) [TaxId: 287 ],	SCOPe (2.08)
F	d1t5ef_	Membrane and cell surface proteins and peptides	HlyD-like secretion proteins	HlyD-like secretion proteins	HlyD-like secretion proteins	Multidrug resistance protein MexA domain	(Pseudomonas aeruginosa ) [TaxId: 287 ],	SCOPe (2.08)
J	d1t5ej_	Membrane and cell surface proteins and peptides	HlyD-like secretion proteins	HlyD-like secretion proteins	HlyD-like secretion proteins	Multidrug resistance protein MexA domain	(Pseudomonas aeruginosa ) [TaxId: 287 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C	SCOP2B Superfamily	HlyD beta-barrel domain-like	8041312	3002000	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Single hybrid motif	8055550	3001880	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Single hybrid motif	8055550	3001880	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	HlyD beta-barrel domain-like	8041312	3002000	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Single hybrid motif	8055550	3001880	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Single hybrid motif	8055550	3001880	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Single hybrid motif	8055550	3001880	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Single hybrid motif	8055550	3001880	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	HlyD beta-barrel domain-like	8041312	3002000	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	HlyD beta-barrel domain-like	8041312	3002000	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Single hybrid motif	8055550	3001880	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Single hybrid motif	8055550	3001880	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	HlyD beta-barrel domain-like	8041312	3002000	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Single hybrid motif	8055550	3001880	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Single hybrid motif	8055550	3001880	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	Single hybrid motif	8055550	3001880	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	HlyD beta-barrel domain-like	8041312	3002000	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	Single hybrid motif	8055550	3001880	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	Single hybrid motif	8055550	3001880	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	Single hybrid motif	8055550	3001880	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	HlyD beta-barrel domain-like	8041312	3002000	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	HlyD beta-barrel domain-like	8041312	3002000	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	Single hybrid motif	8055550	3001880	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	Single hybrid motif	8055550	3001880	SCOP2B (2022-06-29)
M	SCOP2B Superfamily	Single hybrid motif	8055550	3001880	SCOP2B (2022-06-29)
M	SCOP2B Superfamily	Single hybrid motif	8055550	3001880	SCOP2B (2022-06-29)
M	SCOP2B Superfamily	HlyD beta-barrel domain-like	8041312	3002000	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Single hybrid motif	8055550	3001880	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Single hybrid motif	8055550	3001880	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	HlyD beta-barrel domain-like	8041312	3002000	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Single hybrid motif	8055550	3001880	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Single hybrid motif	8055550	3001880	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	HlyD beta-barrel domain-like	8041312	3002000	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	HlyD beta-barrel domain-like	8041312	3002000	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Single hybrid motif	8055550	3001880	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Single hybrid motif	8055550	3001880	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	HlyD beta-barrel domain-like	8041312	3002000	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	Single hybrid motif	8055550	3001880	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	Single hybrid motif	8055550	3001880	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C	HlyD_D23_C_1	e1t5eC4	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: HlyD_D23_C_1	ECOD (1.6)
C	PRK15030_1st	e1t5eC5	A: alpha bundles	X: helical hairpin of HlyD-like secretion proteins (From Topology)	H: helical hairpin of HlyD-like secretion proteins (From Topology)	T: helical hairpin of HlyD-like secretion proteins	F: PRK15030_1st	ECOD (1.6)
C	HlyD_1st	e1t5eC6	A: a+b complex topology	X: alpha/beta-Hammerhead/Barrel-sandwich hybrid	H: alpha/beta-Hammerhead/Barrel-sandwich hybrid	T: Single hybrid motif	F: HlyD_1st	ECOD (1.6)
D	HlyD_D23_C_1	e1t5eD1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: HlyD_D23_C_1	ECOD (1.6)
D	PRK15030_1st	e1t5eD2	A: alpha bundles	X: helical hairpin of HlyD-like secretion proteins (From Topology)	H: helical hairpin of HlyD-like secretion proteins (From Topology)	T: helical hairpin of HlyD-like secretion proteins	F: PRK15030_1st	ECOD (1.6)
D	HlyD_1st	e1t5eD3	A: a+b complex topology	X: alpha/beta-Hammerhead/Barrel-sandwich hybrid	H: alpha/beta-Hammerhead/Barrel-sandwich hybrid	T: Single hybrid motif	F: HlyD_1st	ECOD (1.6)
E	HlyD_D23_C_1	e1t5eE4	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: HlyD_D23_C_1	ECOD (1.6)
E	PRK15030_1st	e1t5eE5	A: alpha bundles	X: helical hairpin of HlyD-like secretion proteins (From Topology)	H: helical hairpin of HlyD-like secretion proteins (From Topology)	T: helical hairpin of HlyD-like secretion proteins	F: PRK15030_1st	ECOD (1.6)
E	HlyD_1st	e1t5eE6	A: a+b complex topology	X: alpha/beta-Hammerhead/Barrel-sandwich hybrid	H: alpha/beta-Hammerhead/Barrel-sandwich hybrid	T: Single hybrid motif	F: HlyD_1st	ECOD (1.6)
G	HlyD_D23_C_1	e1t5eG4	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: HlyD_D23_C_1	ECOD (1.6)
G	PRK15030_1st	e1t5eG5	A: alpha bundles	X: helical hairpin of HlyD-like secretion proteins (From Topology)	H: helical hairpin of HlyD-like secretion proteins (From Topology)	T: helical hairpin of HlyD-like secretion proteins	F: PRK15030_1st	ECOD (1.6)
G	HlyD_1st	e1t5eG6	A: a+b complex topology	X: alpha/beta-Hammerhead/Barrel-sandwich hybrid	H: alpha/beta-Hammerhead/Barrel-sandwich hybrid	T: Single hybrid motif	F: HlyD_1st	ECOD (1.6)
H	HlyD_D23_C_1	e1t5eH4	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: HlyD_D23_C_1	ECOD (1.6)
H	PRK15030_1st	e1t5eH5	A: alpha bundles	X: helical hairpin of HlyD-like secretion proteins (From Topology)	H: helical hairpin of HlyD-like secretion proteins (From Topology)	T: helical hairpin of HlyD-like secretion proteins	F: PRK15030_1st	ECOD (1.6)
H	HlyD_1st	e1t5eH6	A: a+b complex topology	X: alpha/beta-Hammerhead/Barrel-sandwich hybrid	H: alpha/beta-Hammerhead/Barrel-sandwich hybrid	T: Single hybrid motif	F: HlyD_1st	ECOD (1.6)
I	HlyD_D23_C_1	e1t5eI4	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: HlyD_D23_C_1	ECOD (1.6)
I	PRK15030_1st	e1t5eI5	A: alpha bundles	X: helical hairpin of HlyD-like secretion proteins (From Topology)	H: helical hairpin of HlyD-like secretion proteins (From Topology)	T: helical hairpin of HlyD-like secretion proteins	F: PRK15030_1st	ECOD (1.6)
I	HlyD_1st	e1t5eI6	A: a+b complex topology	X: alpha/beta-Hammerhead/Barrel-sandwich hybrid	H: alpha/beta-Hammerhead/Barrel-sandwich hybrid	T: Single hybrid motif	F: HlyD_1st	ECOD (1.6)
K	HlyD_D23_C_1	e1t5eK4	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: HlyD_D23_C_1	ECOD (1.6)
K	PRK15030_1st	e1t5eK5	A: alpha bundles	X: helical hairpin of HlyD-like secretion proteins (From Topology)	H: helical hairpin of HlyD-like secretion proteins (From Topology)	T: helical hairpin of HlyD-like secretion proteins	F: PRK15030_1st	ECOD (1.6)
K	HlyD_1st	e1t5eK6	A: a+b complex topology	X: alpha/beta-Hammerhead/Barrel-sandwich hybrid	H: alpha/beta-Hammerhead/Barrel-sandwich hybrid	T: Single hybrid motif	F: HlyD_1st	ECOD (1.6)
L	HlyD_D23_C_1	e1t5eL1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: HlyD_D23_C_1	ECOD (1.6)
L	PRK15030_1st	e1t5eL2	A: alpha bundles	X: helical hairpin of HlyD-like secretion proteins (From Topology)	H: helical hairpin of HlyD-like secretion proteins (From Topology)	T: helical hairpin of HlyD-like secretion proteins	F: PRK15030_1st	ECOD (1.6)
L	HlyD_1st	e1t5eL3	A: a+b complex topology	X: alpha/beta-Hammerhead/Barrel-sandwich hybrid	H: alpha/beta-Hammerhead/Barrel-sandwich hybrid	T: Single hybrid motif	F: HlyD_1st	ECOD (1.6)
M	HlyD_D23_C_1	e1t5eM4	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: HlyD_D23_C_1	ECOD (1.6)
M	PRK15030_1st	e1t5eM5	A: alpha bundles	X: helical hairpin of HlyD-like secretion proteins (From Topology)	H: helical hairpin of HlyD-like secretion proteins (From Topology)	T: helical hairpin of HlyD-like secretion proteins	F: PRK15030_1st	ECOD (1.6)
M	HlyD_1st	e1t5eM6	A: a+b complex topology	X: alpha/beta-Hammerhead/Barrel-sandwich hybrid	H: alpha/beta-Hammerhead/Barrel-sandwich hybrid	T: Single hybrid motif	F: HlyD_1st	ECOD (1.6)
A	HlyD_D23_C_1	e1t5eA4	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: HlyD_D23_C_1	ECOD (1.6)
A	PRK15030_1st	e1t5eA5	A: alpha bundles	X: helical hairpin of HlyD-like secretion proteins (From Topology)	H: helical hairpin of HlyD-like secretion proteins (From Topology)	T: helical hairpin of HlyD-like secretion proteins	F: PRK15030_1st	ECOD (1.6)
A	HlyD_1st	e1t5eA6	A: a+b complex topology	X: alpha/beta-Hammerhead/Barrel-sandwich hybrid	H: alpha/beta-Hammerhead/Barrel-sandwich hybrid	T: Single hybrid motif	F: HlyD_1st	ECOD (1.6)
B	HlyD_D23_C_1	e1t5eB4	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: HlyD_D23_C_1	ECOD (1.6)
B	PRK15030_1st	e1t5eB5	A: alpha bundles	X: helical hairpin of HlyD-like secretion proteins (From Topology)	H: helical hairpin of HlyD-like secretion proteins (From Topology)	T: helical hairpin of HlyD-like secretion proteins	F: PRK15030_1st	ECOD (1.6)
B	HlyD_1st	e1t5eB6	A: a+b complex topology	X: alpha/beta-Hammerhead/Barrel-sandwich hybrid	H: alpha/beta-Hammerhead/Barrel-sandwich hybrid	T: Single hybrid motif	F: HlyD_1st	ECOD (1.6)
F	HlyD_D23_C_1	e1t5eF4	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: HlyD_D23_C_1	ECOD (1.6)
F	PRK15030_1st	e1t5eF5	A: alpha bundles	X: helical hairpin of HlyD-like secretion proteins (From Topology)	H: helical hairpin of HlyD-like secretion proteins (From Topology)	T: helical hairpin of HlyD-like secretion proteins	F: PRK15030_1st	ECOD (1.6)
F	HlyD_1st	e1t5eF6	A: a+b complex topology	X: alpha/beta-Hammerhead/Barrel-sandwich hybrid	H: alpha/beta-Hammerhead/Barrel-sandwich hybrid	T: Single hybrid motif	F: HlyD_1st	ECOD (1.6)
J	HlyD_D23_C_1	e1t5eJ4	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: HlyD_D23_C_1	ECOD (1.6)
J	PRK15030_1st	e1t5eJ5	A: alpha bundles	X: helical hairpin of HlyD-like secretion proteins (From Topology)	H: helical hairpin of HlyD-like secretion proteins (From Topology)	T: helical hairpin of HlyD-like secretion proteins	F: PRK15030_1st	ECOD (1.6)
J	HlyD_1st	e1t5eJ6	A: a+b complex topology	X: alpha/beta-Hammerhead/Barrel-sandwich hybrid	H: alpha/beta-Hammerhead/Barrel-sandwich hybrid	T: Single hybrid motif	F: HlyD_1st	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C	2.40.30.170	Mainly Beta	Beta Barrel	Elongation Factor Tu (Ef-tu)	domain 3	CATH (4.3.0)
C	2.40.50.100	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)	RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain	CATH (4.3.0)
C	1.10.287.470	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	Helix hairpin bin	CATH (4.3.0)
D	2.40.30.170	Mainly Beta	Beta Barrel	Elongation Factor Tu (Ef-tu)	domain 3	CATH (4.3.0)
D	2.40.50.100	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)	RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain	CATH (4.3.0)
D	1.10.287.470	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	Helix hairpin bin	CATH (4.3.0)
E	2.40.30.170	Mainly Beta	Beta Barrel	Elongation Factor Tu (Ef-tu)	domain 3	CATH (4.3.0)
E	2.40.50.100	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)	RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain	CATH (4.3.0)
E	1.10.287.470	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	Helix hairpin bin	CATH (4.3.0)
G	2.40.30.170	Mainly Beta	Beta Barrel	Elongation Factor Tu (Ef-tu)	domain 3	CATH (4.3.0)
G	2.40.50.100	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)	RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain	CATH (4.3.0)
G	1.10.287.470	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	Helix hairpin bin	CATH (4.3.0)
H	2.40.30.170	Mainly Beta	Beta Barrel	Elongation Factor Tu (Ef-tu)	domain 3	CATH (4.3.0)
H	2.40.50.100	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)	RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain	CATH (4.3.0)
H	1.10.287.470	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	Helix hairpin bin	CATH (4.3.0)
I	2.40.30.170	Mainly Beta	Beta Barrel	Elongation Factor Tu (Ef-tu)	domain 3	CATH (4.3.0)
I	2.40.50.100	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)	RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain	CATH (4.3.0)
I	1.10.287.470	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	Helix hairpin bin	CATH (4.3.0)
K	2.40.30.170	Mainly Beta	Beta Barrel	Elongation Factor Tu (Ef-tu)	domain 3	CATH (4.3.0)
K	2.40.50.100	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)	RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain	CATH (4.3.0)
K	1.10.287.470	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	Helix hairpin bin	CATH (4.3.0)
L	2.40.30.170	Mainly Beta	Beta Barrel	Elongation Factor Tu (Ef-tu)	domain 3	CATH (4.3.0)
L	2.40.50.100	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)	RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain	CATH (4.3.0)
L	1.10.287.470	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	Helix hairpin bin	CATH (4.3.0)
M	2.40.30.170	Mainly Beta	Beta Barrel	Elongation Factor Tu (Ef-tu)	domain 3	CATH (4.3.0)
M	2.40.50.100	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)	RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain	CATH (4.3.0)
M	1.10.287.470	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	Helix hairpin bin	CATH (4.3.0)
A	2.40.30.170	Mainly Beta	Beta Barrel	Elongation Factor Tu (Ef-tu)	domain 3	CATH (4.3.0)
A	2.40.50.100	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)	RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain	CATH (4.3.0)
A	1.10.287.470	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	Helix hairpin bin	CATH (4.3.0)
B	2.40.30.170	Mainly Beta	Beta Barrel	Elongation Factor Tu (Ef-tu)	domain 3	CATH (4.3.0)
B	2.40.50.100	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)	RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain	CATH (4.3.0)
B	1.10.287.470	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	Helix hairpin bin	CATH (4.3.0)
F	2.40.30.170	Mainly Beta	Beta Barrel	Elongation Factor Tu (Ef-tu)	domain 3	CATH (4.3.0)
F	2.40.50.100	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)	RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain	CATH (4.3.0)
F	1.10.287.470	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	Helix hairpin bin	CATH (4.3.0)
J	2.40.30.170	Mainly Beta	Beta Barrel	Elongation Factor Tu (Ef-tu)	domain 3	CATH (4.3.0)
J	2.40.50.100	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)	RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain	CATH (4.3.0)
J	1.10.287.470	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	Helix hairpin bin	CATH (4.3.0)

AMR Gene: CARD Annotation CARD Database Homepage

Chains	Accession	Short Name	Description	Provenance Source (Version)
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M	ARO:3000377	MexA	MexA is the membrane fusion protein of the MexAB-OprM multidrug efflux complex.	CARD (3.3.0)

AMR Gene Family: CARD Annotation CARD Database Homepage

Chains	Accession	Gene Family	Drug Class	Resistance Machanism	Provenance Source (Version)
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M	ARO:0010004	resistance-nodulation-cell division (RND) antibiotic efflux pump	macrolide antibiotic, fluoroquinolone antibiotic, monobactam, carbapenem, cephalosporin, cephamycin, penam, tetracycline antibiotic, peptide antibiotic, aminocoumarin antibiotic, diaminopyrimidine antibiotic, sulfonamide antibiotic, phenicol antibiotic, penem	antibiotic efflux	CARD (3.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M	PF16576	Barrel-sandwich domain of CusB or HlyD membrane-fusion (HlyD_D23)	Barrel-sandwich domain of CusB or HlyD membrane-fusion	HlyD_D23 is the combined domains 2 and 3 of the membrane-fusion proteins CusB and HlyD, which forms a barrel-sandwich. CusB and HlyD proteins are membrane fusion proteins of the CusCFBA copper efflux system in E.coli and related bacteria. The whole ...	HlyD_D23 is the combined domains 2 and 3 of the membrane-fusion proteins CusB and HlyD, which forms a barrel-sandwich. CusB and HlyD proteins are membrane fusion proteins of the CusCFBA copper efflux system in E.coli and related bacteria. The whole molecule hinges between D2 and D3. Efflux systems of this resistance-nodulation-division group - RND - have been developed to excrete poisonous metal ions, and in E.coli the only one that deals with silver and copper is the CusA transporter. The transporter CusA works in conjunction with a periplasmic component that is a membrane fusion protein, eg CusB, and an outer-membrane channel component CusC in a CusABC complex driven by import of protons.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M	Multidrug resistance protein mexA	efflux transmembrane transporter activity transporter activity transmembrane transporter activity identical protein binding protein binding binding	cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein complex oligomerization protein-containing complex assembly protein homooligomerization cellular process cellular component organization or biogenesis transmembrane transport localization transport establishment of localization response to stimulus cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein complex oligomerization protein-containing complex assembly protein homooligomerization cellular process cellular component organization or biogenesis transmembrane transport localization transport establishment of localization response to stimulus response to chemical response to antibiotic	cell periphery cellular anatomical structure plasma membrane membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M	IPR051160	Membrane Fusion Protein (MFP) Efflux	Family
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M	IPR006143	RND efflux pump, membrane fusion protein	Family
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M	IPR043602	Cation efflux system protein CusB, domain 1	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M	IPR032317	RND efflux pump, membrane fusion protein, barrel-sandwich domain	Domain

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Multi-Drug Efflux Transporters	MexA membrane fusion protein