1UEB

Crystal structure of translation elongation factor P from Thermus thermophilus HB8

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1ueba1	All beta proteins	SH3-like barrel	Translation proteins SH3-like domain	eIF5a N-terminal domain-like	Elongation factor P N-terminal domain	(Thermus thermophilus ) [TaxId: 274 ],	SCOPe (2.08)
A	d1ueba2	All beta proteins	OB-fold	Nucleic acid-binding proteins	Cold shock DNA-binding domain-like	Elongation factor P middle and C-terminal domains	(Thermus thermophilus ) [TaxId: 274 ],	SCOPe (2.08)
B	d1uebb1	All beta proteins	SH3-like barrel	Translation proteins SH3-like domain	eIF5a N-terminal domain-like	Elongation factor P N-terminal domain	(Thermus thermophilus ) [TaxId: 274 ],	SCOPe (2.08)
B	d1uebb2	All beta proteins	OB-fold	Nucleic acid-binding proteins	Cold shock DNA-binding domain-like	Elongation factor P middle and C-terminal domains	(Thermus thermophilus ) [TaxId: 274 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	eIF5a N-terminal domain-like	8028422	4001758	SCOP2 (2022-06-29)
A	SCOP2 Family	Cold shock DNA-binding domain-like	8028425	4001909	SCOP2 (2022-06-29)
A	SCOP2 Family	Cold shock DNA-binding domain-like	8028427	4001909	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Translation proteins SH3-like KOW motif containing domain	8040801	3000334	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Nucleic acid-binding proteins	8040804	3000135	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Nucleic acid-binding proteins	8040806	3000135	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Translation proteins SH3-like KOW motif containing domain	8040801	3000334	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Nucleic acid-binding proteins	8040804	3000135	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Nucleic acid-binding proteins	8040806	3000135	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	EFP	e1uebA1	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: EFP	ECOD (1.6)
A	Elong-fact-P_C	e1uebA2	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: Elong-fact-P_C	ECOD (1.6)
A	EFP_N	e1uebA3	A: beta barrels	X: SH3	H: SH3	T: SH3	F: EFP_N	ECOD (1.6)
B	EFP	e1uebB1	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: EFP	ECOD (1.6)
B	Elong-fact-P_C	e1uebB2	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: Elong-fact-P_C	ECOD (1.6)
B	EFP_N	e1uebB3	A: beta barrels	X: SH3	H: SH3	T: SH3	F: EFP_N	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.30.30.30	Mainly Beta	Roll	SH3 type barrels.		CATH (4.3.0)
A	2.40.50.140	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)	Nucleic acid-binding proteins	CATH (4.3.0)
B	2.30.30.30	Mainly Beta	Roll	SH3 type barrels.		CATH (4.3.0)
B	2.40.50.140	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)	Nucleic acid-binding proteins	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF09285	Elongation factor P, C-terminal (Elong-fact-P_C)	Elongation factor P, C-terminal	Members of this family of nucleic acid binding domains are predominantly found in elongation factor P, where they adopt an OB-fold, with five beta-strands forming a beta-barrel in a Greek-key topology [1].	Domain
A, B	PF01132	Elongation factor P (EF-P) OB domain (EFP)	Elongation factor P (EF-P) OB domain	-	Domain
A, B	PF08207	Elongation factor P (EF-P) KOW-like domain (EFP_N)	Elongation factor P (EF-P) KOW-like domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	elongation factor P	translation regulator activity binding organic cyclic compound binding translation regulator activity, nucleic acid binding translation elongation factor activity nucleic acid binding translation factor activity, RNA binding	peptide biosynthetic process biosynthetic process metabolic process peptide metabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR011768	Translation elongation factor P	Family
A, B	IPR020599	Translation elongation factor P/YeiP	Family
A, B	IPR015365	Elongation factor P, C-terminal	Domain
A, B	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
A, B	IPR013185	Translation elongation factor, KOW-like	Domain
A, B	IPR014722	Large ribosomal subunit protein uL2, domain 2	Homologous Superfamily
A, B	IPR013852	Translation elongation factor P/YeiP, conserved site	Conserved Site
A, B	IPR008991	Translation protein SH3-like domain superfamily	Homologous Superfamily
A, B	IPR001059	Translation elongation factor P/YeiP, central	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.