1UUM

Rat dihydroorotate dehydrogenase (DHOD)in complex with atovaquone

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM
Membrane Protein Annotation: mpstruc

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1uuma_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	FMN-linked oxidoreductases	FMN-linked oxidoreductases	Dihydroorotate dehydrogenase	BLACK RAT, ROOF RAT (Rattus rattus ) [TaxId: 10117 ],	SCOPe (2.08)
B	d1uumb_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	FMN-linked oxidoreductases	FMN-linked oxidoreductases	Dihydroorotate dehydrogenase	BLACK RAT, ROOF RAT (Rattus rattus ) [TaxId: 10117 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	FMN-linked oxidoreductases	8058081	4000080	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	FMN-linked oxidoreductases	8058082	3000014	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	FMN-linked oxidoreductases	8058082	3000014	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	DHO_dh	e1uumA1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: DHO_dh	ECOD (1.6)
B	DHO_dh	e1uumB1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: DHO_dh	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
B	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF01180	Dihydroorotate dehydrogenase (DHO_dh)	Dihydroorotate dehydrogenase	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	DIHYDROOROTATE DEHYDROGENASE	dihydroorotase activity hydrolase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides catalytic activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds binding nucleotide binding FMN binding nucleoside phosphate binding ion binding organic cyclic compound binding anion binding heterocyclic compound binding carbohydrate derivative binding dihydroorotase activity hydrolase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides catalytic activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds binding nucleotide binding FMN binding nucleoside phosphate binding ion binding organic cyclic compound binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding oxidoreductase activity dihydroorotate dehydrogenase activity oxidoreductase activity, acting on the CH-CH group of donors dihydroorotate dehydrogenase (quinone) activity oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor quinone binding ubiquinone binding	response to stimulus response to chemical response to xenobiotic stimulus multi-multicellular organism process multicellular organismal process reproductive process female pregnancy multi-organism reproductive process regulation of biological process positive regulation of programmed cell death regulation of cellular process regulation of apoptotic process biological regulation positive regulation of biological process response to stimulus response to chemical response to xenobiotic stimulus multi-multicellular organism process multicellular organismal process reproductive process female pregnancy multi-organism reproductive process regulation of biological process positive regulation of programmed cell death regulation of cellular process regulation of apoptotic process biological regulation positive regulation of biological process regulation of programmed cell death cell death positive regulation of apoptotic process cellular process apoptotic process programmed cell death positive regulation of cellular process developmental process regulation of cellular component organization regulation of developmental process organelle fission mitochondrial fission regulation of organelle organization cellular component organization anatomical structure morphogenesis organelle organization regulation of mitochondrial fission regulation of mitochondrion organization anatomical structure development cellular component organization or biogenesis regulation of anatomical structure morphogenesis mitochondrion organization response to nitrogen compound response to purine-containing compound response to organic cyclic compound response to caffeine response to alkaloid ribose phosphate metabolic process pyrimidine nucleoside diphosphate metabolic process nucleotide biosynthetic process carbohydrate derivative metabolic process pyrimidine nucleotide metabolic process UDP metabolic process nucleobase-containing compound metabolic process nucleoside diphosphate biosynthetic process ribonucleotide biosynthetic process ribonucleotide metabolic process nucleobase-containing small molecule metabolic process pyrimidine ribonucleoside diphosphate metabolic process ribonucleoside diphosphate metabolic process phosphate-containing compound metabolic process small molecule metabolic process pyrimidine-containing compound biosynthetic process phosphorus metabolic process ribose phosphate biosynthetic process pyrimidine ribonucleotide metabolic process nucleoside phosphate metabolic process carbohydrate derivative biosynthetic process pyrimidine-containing compound metabolic process primary metabolic process pyrimidine ribonucleoside diphosphate biosynthetic process nucleobase-containing compound biosynthetic process nucleotide metabolic process nucleoside diphosphate metabolic process UDP biosynthetic process biosynthetic process organophosphate metabolic process organophosphate biosynthetic process pyrimidine nucleoside diphosphate biosynthetic process nucleoside phosphate biosynthetic process metabolic process pyrimidine nucleotide biosynthetic process ribonucleoside diphosphate biosynthetic process pyrimidine ribonucleotide biosynthetic process regulation of body fluid levels secretion transport mammary gland development gland development animal organ development establishment of localization body fluid secretion localization lactation regulation of biological quality nucleobase biosynthetic process pyrimidine nucleobase biosynthetic process pyrimidine nucleobase metabolic process nucleobase metabolic process 'de novo' pyrimidine nucleobase biosynthetic process 'de novo' UMP biosynthetic process UMP biosynthetic process ribonucleoside monophosphate metabolic process UMP metabolic process nucleoside monophosphate metabolic process pyrimidine nucleoside monophosphate metabolic process pyrimidine ribonucleoside monophosphate metabolic process nucleoside monophosphate biosynthetic process pyrimidine ribonucleoside monophosphate biosynthetic process pyrimidine nucleoside monophosphate biosynthetic process ribonucleoside monophosphate biosynthetic process response to acid chemical response to L-arginine response to oxygen-containing compound response to amino acid response to nutrient levels response to stress response to starvation	membrane-bounded organelle mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion membrane intracellular membrane-bounded organelle mitochondrial inner membrane intracellular organelle organelle envelope cellular anatomical structure mitochondrial envelope organelle cytoplasm membrane-bounded organelle mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion membrane intracellular membrane-bounded organelle mitochondrial inner membrane intracellular organelle organelle envelope cellular anatomical structure mitochondrial envelope organelle cytoplasm organelle membrane somatodendritic compartment cell body neuronal cell body

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR013785	Aldolase-type TIM barrel	Homologous Superfamily
A, B	IPR001295	Dihydroorotate dehydrogenase, conserved site	Conserved Site
A, B	IPR005719	Dihydroorotate dehydrogenase, class 2	Family
A, B	IPR005720	Dihydroorotate dehydrogenase, catalytic	Domain
A, B	IPR050074	Dihydroorotate dehydrogenase	Family

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B	OPM	Transmembrane	Bitopic proteins	FMN-linked oxidoreductases	FMN-dependent dehydrogenase

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B	mpstruc	MONOTOPIC MEMBRANE PROTEINS	Dihydroorotate Dehydrogenases (DHODH, class 2)	Dihydroorotate Dehydrogenase in complex with atovaquone

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.