1UW6

X-ray structure of acetylcholine binding protein (AChBP) in complex with nicotine

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1uw6a_	All beta proteins	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Acetylcholine binding protein (ACHBP)	GREAT POND SNAIL (Lymnaea stagnalis ) [TaxId: 6523 ],	SCOPe (2.08)
B	d1uw6b_	All beta proteins	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Acetylcholine binding protein (ACHBP)	GREAT POND SNAIL (Lymnaea stagnalis ) [TaxId: 6523 ],	SCOPe (2.08)
E	d1uw6e_	All beta proteins	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Acetylcholine binding protein (ACHBP)	GREAT POND SNAIL (Lymnaea stagnalis ) [TaxId: 6523 ],	SCOPe (2.08)
F	d1uw6f_	All beta proteins	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Acetylcholine binding protein (ACHBP)	GREAT POND SNAIL (Lymnaea stagnalis ) [TaxId: 6523 ],	SCOPe (2.08)
G	d1uw6g_	All beta proteins	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Acetylcholine binding protein (ACHBP)	GREAT POND SNAIL (Lymnaea stagnalis ) [TaxId: 6523 ],	SCOPe (2.08)
H	d1uw6h_	All beta proteins	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Acetylcholine binding protein (ACHBP)	GREAT POND SNAIL (Lymnaea stagnalis ) [TaxId: 6523 ],	SCOPe (2.08)
I	d1uw6i_	All beta proteins	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Acetylcholine binding protein (ACHBP)	GREAT POND SNAIL (Lymnaea stagnalis ) [TaxId: 6523 ],	SCOPe (2.08)
J	d1uw6j_	All beta proteins	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Acetylcholine binding protein (ACHBP)	GREAT POND SNAIL (Lymnaea stagnalis ) [TaxId: 6523 ],	SCOPe (2.08)
K	d1uw6k_	All beta proteins	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Acetylcholine binding protein (ACHBP)	GREAT POND SNAIL (Lymnaea stagnalis ) [TaxId: 6523 ],	SCOPe (2.08)
L	d1uw6l_	All beta proteins	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Acetylcholine binding protein (ACHBP)	GREAT POND SNAIL (Lymnaea stagnalis ) [TaxId: 6523 ],	SCOPe (2.08)
M	d1uw6m_	All beta proteins	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Acetylcholine binding protein (ACHBP)	GREAT POND SNAIL (Lymnaea stagnalis ) [TaxId: 6523 ],	SCOPe (2.08)
N	d1uw6n_	All beta proteins	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Acetylcholine binding protein (ACHBP)	GREAT POND SNAIL (Lymnaea stagnalis ) [TaxId: 6523 ],	SCOPe (2.08)
O	d1uw6o_	All beta proteins	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Acetylcholine binding protein (ACHBP)	GREAT POND SNAIL (Lymnaea stagnalis ) [TaxId: 6523 ],	SCOPe (2.08)
Q	d1uw6q_	All beta proteins	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Acetylcholine binding protein (ACHBP)	GREAT POND SNAIL (Lymnaea stagnalis ) [TaxId: 6523 ],	SCOPe (2.08)
R	d1uw6r_	All beta proteins	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Acetylcholine binding protein (ACHBP)	GREAT POND SNAIL (Lymnaea stagnalis ) [TaxId: 6523 ],	SCOPe (2.08)
S	d1uw6s_	All beta proteins	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Acetylcholine binding protein (ACHBP)	GREAT POND SNAIL (Lymnaea stagnalis ) [TaxId: 6523 ],	SCOPe (2.08)
T	d1uw6t_	All beta proteins	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Acetylcholine binding protein (ACHBP)	GREAT POND SNAIL (Lymnaea stagnalis ) [TaxId: 6523 ],	SCOPe (2.08)
C	d1uw6c_	All beta proteins	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Acetylcholine binding protein (ACHBP)	GREAT POND SNAIL (Lymnaea stagnalis ) [TaxId: 6523 ],	SCOPe (2.08)
D	d1uw6d_	All beta proteins	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Acetylcholine binding protein (ACHBP)	GREAT POND SNAIL (Lymnaea stagnalis ) [TaxId: 6523 ],	SCOPe (2.08)
P	d1uw6p_	All beta proteins	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Acetylcholine binding protein (ACHBP)	GREAT POND SNAIL (Lymnaea stagnalis ) [TaxId: 6523 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	nicotinic receptor ligand binding domain-like	8022830	4003166	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Nicotinic receptor ligand binding domain-like	8035210	3000369	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Nicotinic receptor ligand binding domain-like	8035210	3000369	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Nicotinic receptor ligand binding domain-like	8035210	3000369	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Nicotinic receptor ligand binding domain-like	8035210	3000369	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Nicotinic receptor ligand binding domain-like	8035210	3000369	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Nicotinic receptor ligand binding domain-like	8035210	3000369	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	Nicotinic receptor ligand binding domain-like	8035210	3000369	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	Nicotinic receptor ligand binding domain-like	8035210	3000369	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	Nicotinic receptor ligand binding domain-like	8035210	3000369	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	Nicotinic receptor ligand binding domain-like	8035210	3000369	SCOP2B (2022-06-29)
M	SCOP2B Superfamily	Nicotinic receptor ligand binding domain-like	8035210	3000369	SCOP2B (2022-06-29)
N	SCOP2B Superfamily	Nicotinic receptor ligand binding domain-like	8035210	3000369	SCOP2B (2022-06-29)
O	SCOP2B Superfamily	Nicotinic receptor ligand binding domain-like	8035210	3000369	SCOP2B (2022-06-29)
Q	SCOP2B Superfamily	Nicotinic receptor ligand binding domain-like	8035210	3000369	SCOP2B (2022-06-29)
R	SCOP2B Superfamily	Nicotinic receptor ligand binding domain-like	8035210	3000369	SCOP2B (2022-06-29)
S	SCOP2B Superfamily	Nicotinic receptor ligand binding domain-like	8035210	3000369	SCOP2B (2022-06-29)
T	SCOP2B Superfamily	Nicotinic receptor ligand binding domain-like	8035210	3000369	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Nicotinic receptor ligand binding domain-like	8035210	3000369	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Nicotinic receptor ligand binding domain-like	8035210	3000369	SCOP2B (2022-06-29)
P	SCOP2B Superfamily	Nicotinic receptor ligand binding domain-like	8035210	3000369	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Neur_chan_LBD	e1uw6A1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: Neur_chan_LBD	ECOD (1.6)
B	Neur_chan_LBD	e1uw6B1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: Neur_chan_LBD	ECOD (1.6)
E	Neur_chan_LBD	e1uw6E1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: Neur_chan_LBD	ECOD (1.6)
F	Neur_chan_LBD	e1uw6F1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: Neur_chan_LBD	ECOD (1.6)
G	Neur_chan_LBD	e1uw6G1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: Neur_chan_LBD	ECOD (1.6)
H	Neur_chan_LBD	e1uw6H1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: Neur_chan_LBD	ECOD (1.6)
I	Neur_chan_LBD	e1uw6I1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: Neur_chan_LBD	ECOD (1.6)
J	Neur_chan_LBD	e1uw6J1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: Neur_chan_LBD	ECOD (1.6)
K	Neur_chan_LBD	e1uw6K1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: Neur_chan_LBD	ECOD (1.6)
L	Neur_chan_LBD	e1uw6L1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: Neur_chan_LBD	ECOD (1.6)
M	Neur_chan_LBD	e1uw6M1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: Neur_chan_LBD	ECOD (1.6)
N	Neur_chan_LBD	e1uw6N1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: Neur_chan_LBD	ECOD (1.6)
O	Neur_chan_LBD	e1uw6O1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: Neur_chan_LBD	ECOD (1.6)
Q	Neur_chan_LBD	e1uw6Q1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: Neur_chan_LBD	ECOD (1.6)
R	Neur_chan_LBD	e1uw6R1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: Neur_chan_LBD	ECOD (1.6)
S	Neur_chan_LBD	e1uw6S1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: Neur_chan_LBD	ECOD (1.6)
T	Neur_chan_LBD	e1uw6T1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: Neur_chan_LBD	ECOD (1.6)
C	Neur_chan_LBD	e1uw6C1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: Neur_chan_LBD	ECOD (1.6)
D	Neur_chan_LBD	e1uw6D1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: Neur_chan_LBD	ECOD (1.6)
P	Neur_chan_LBD	e1uw6P1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: Neur_chan_LBD	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein	Chain: A,	CATH (4.3.0)
B	2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein	Chain: A,	CATH (4.3.0)
E	2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein	Chain: A,	CATH (4.3.0)
F	2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein	Chain: A,	CATH (4.3.0)
G	2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein	Chain: A,	CATH (4.3.0)
H	2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein	Chain: A,	CATH (4.3.0)
I	2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein	Chain: A,	CATH (4.3.0)
J	2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein	Chain: A,	CATH (4.3.0)
K	2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein	Chain: A,	CATH (4.3.0)
L	2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein	Chain: A,	CATH (4.3.0)
M	2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein	Chain: A,	CATH (4.3.0)
N	2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein	Chain: A,	CATH (4.3.0)
O	2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein	Chain: A,	CATH (4.3.0)
Q	2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein	Chain: A,	CATH (4.3.0)
R	2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein	Chain: A,	CATH (4.3.0)
S	2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein	Chain: A,	CATH (4.3.0)
T	2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein	Chain: A,	CATH (4.3.0)
C	2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein	Chain: A,	CATH (4.3.0)
D	2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein	Chain: A,	CATH (4.3.0)
P	2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein	Chain: A,	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T	PF02931	Neurotransmitter-gated ion-channel ligand binding domain (Neur_chan_LBD)	Neurotransmitter-gated ion-channel ligand binding domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T	ACETYLCHOLINE-BINDING PROTEIN	transmitter-gated monoatomic ion channel activity molecular transducer activity gated channel activity monoatomic ion channel activity transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential signaling receptor activity neurotransmitter receptor activity ligand-gated channel activity ligand-gated monoatomic ion channel activity extracellular ligand-gated monoatomic ion channel activity postsynaptic neurotransmitter receptor activity passive transmembrane transporter activity neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential channel activity transmitter-gated channel activity transmitter-gated monoatomic ion channel activity molecular transducer activity gated channel activity monoatomic ion channel activity transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential signaling receptor activity neurotransmitter receptor activity ligand-gated channel activity ligand-gated monoatomic ion channel activity extracellular ligand-gated monoatomic ion channel activity postsynaptic neurotransmitter receptor activity passive transmembrane transporter activity neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential channel activity transmitter-gated channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity excitatory extracellular ligand-gated monoatomic ion channel activity transmembrane signaling receptor activity	-	synaptic cleft extracellular region cellular anatomical entity membrane postsynapse synapse cell junction cell projection neuron projection plasma membrane bounded cell projection

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T	IPR007110	Immunoglobulin-like domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T	IPR006202	Neurotransmitter-gated ion-channel ligand-binding domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T	IPR036734	Neurotransmitter-gated ion-channel ligand-binding domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T	IPR006201	Neurotransmitter-gated ion-channel	Family