Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad1v93a_ Alpha and beta proteins (a/b) TIM beta/alpha-barrel FAD-linked oxidoreductase Methylenetetrahydrofolate reductase Methylenetetrahydrofolate reductase (Thermus thermophilus HB8 ) [TaxId: 300852 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2 FamilyMethylenetetrahydrofolate reductase 8023263 4003348 SCOP2 (2022-06-29)
ASCOP2 SuperfamilyFAD-linked oxidoreductase 8035643 3000663 SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AMTHFRe1v93A1 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: MTHFRECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.20.20.220 Alpha Beta Alpha-Beta Barrel TIM Barrel CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF02219Methylenetetrahydrofolate reductase (MTHFR)Methylenetetrahydrofolate reductaseThis family includes the 5,10-methylenetetrahydrofolate reductase EC:1.7.99.5 from bacteria and methylenetetrahydrofolate reductase EC: 1.5.1.20 from eukaryotes. The structure for this domain is known [1] to be a TIM barrel.Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
5,10-Methylenetetrahydrofolate reductase

InterPro: Protein Family Classification InterPro Database Homepage