1W1W

Sc Smc1hd:Scc1-C complex, ATPgS

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
E	d1w1we_	All alpha proteins	DNA/RNA-binding 3-helical bundle	'Winged helix' DNA-binding domain	Rad21/Rec8-like	Sister chromatid cohesion protein 1 (SCC1), C-terminal domain	BAKER'S YEAST (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
F	d1w1wf_	All alpha proteins	DNA/RNA-binding 3-helical bundle	'Winged helix' DNA-binding domain	Rad21/Rec8-like	Sister chromatid cohesion protein 1 (SCC1), C-terminal domain	BAKER'S YEAST (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
G	d1w1wg_	All alpha proteins	DNA/RNA-binding 3-helical bundle	'Winged helix' DNA-binding domain	Rad21/Rec8-like	Sister chromatid cohesion protein 1 (SCC1), C-terminal domain	BAKER'S YEAST (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
H	d1w1wh_	All alpha proteins	DNA/RNA-binding 3-helical bundle	'Winged helix' DNA-binding domain	Rad21/Rec8-like	Sister chromatid cohesion protein 1 (SCC1), C-terminal domain	BAKER'S YEAST (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
A	d1w1wa_	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	ABC transporter ATPase domain-like	Smc head domain	BAKER'S YEAST (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
B	d1w1wb_	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	ABC transporter ATPase domain-like	Smc head domain	BAKER'S YEAST (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
C	d1w1wc_	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	ABC transporter ATPase domain-like	Smc head domain	BAKER'S YEAST (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
D	d1w1wd_	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	ABC transporter ATPase domain-like	Smc head domain	BAKER'S YEAST (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
E	SCOP2 Family	Rad21/Rec8-like	8003273	4000258	SCOP2 (2022-06-29)
E	SCOP2 Superfamily	Winged helix DNA-binding domain	8003274	3000034	SCOP2 (2022-06-29)
F	SCOP2B Superfamily	Winged helix DNA-binding domain	8003274	3000034	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Winged helix DNA-binding domain	8003274	3000034	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Winged helix DNA-binding domain	8003274	3000034	SCOP2B (2022-06-29)
A	SCOP2 Family	SMC-like	8056733	4004016	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	ABC transporter-like P-loop ATPases	8056734	3002020	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	ABC transporter-like P-loop ATPases	8056734	3002020	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	ABC transporter-like P-loop ATPases	8056734	3002020	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	ABC transporter-like P-loop ATPases	8056734	3002020	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
E	Rad21_Rec8	e1w1wE1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: Rad21_Rec8	ECOD (1.6)
F	Rad21_Rec8	e1w1wF1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: Rad21_Rec8	ECOD (1.6)
G	Rad21_Rec8	e1w1wG1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: Rad21_Rec8	ECOD (1.6)
H	Rad21_Rec8	e1w1wH1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: Rad21_Rec8	ECOD (1.6)
A	SMC_N	e1w1wA1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: SMC_N	ECOD (1.6)
B	SMC_N	e1w1wB1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: SMC_N	ECOD (1.6)
C	SMC_N	e1w1wC1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: SMC_N	ECOD (1.6)
D	SMC_N	e1w1wD1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: SMC_N	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
E	1.10.10.580	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Structural maintenance of chromosome 1. Chain E	CATH (4.3.0)
F	1.10.10.580	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Structural maintenance of chromosome 1. Chain E	CATH (4.3.0)
G	1.10.10.580	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Structural maintenance of chromosome 1. Chain E	CATH (4.3.0)
H	1.10.10.580	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Structural maintenance of chromosome 1. Chain E	CATH (4.3.0)
A	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
B	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
C	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
D	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
E, F, G, H	PF04824	Conserved region of Rad21 / Rec8 like protein (Rad21_Rec8)	Conserved region of Rad21 / Rec8 like protein	-	Family
A, B, C, D	PF02463	RecF/RecN/SMC N terminal domain (SMC_N)	RecF/RecN/SMC N terminal domain	This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. T ...	This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics [1]. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
E, F, G, H	SISTER CHROMATID COHESION PROTEIN 1	protein binding binding kinase binding enzyme binding protein kinase binding chromatin binding	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process double-strand break repair DNA recombination primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process replication-born double-strand break repair via sister chromatid exchange recombinational repair cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process double-strand break repair DNA recombination primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process replication-born double-strand break repair via sister chromatid exchange recombinational repair metabolic process macromolecule metabolic process double-strand break repair via homologous recombination DNA repair protein acetylation macromolecule modification protein metabolic process protein modification process protein acylation cell division cellular component organization organelle organization mitotic sister chromatid cohesion chromosome organization sister chromatid cohesion cellular component organization or biogenesis cell cycle cell cycle process apoptotic process cell death programmed cell death mitotic nuclear division mitotic chromosome condensation organelle fission sister chromatid segregation mitotic cell cycle nuclear division mitotic cell cycle process chromosome condensation mitotic sister chromatid segregation nuclear chromosome segregation chromosome segregation cell cycle G2/M phase transition G2/M transition of mitotic cell cycle cell cycle phase transition mitotic cell cycle phase transition establishment of mitotic sister chromatid cohesion establishment of sister chromatid cohesion	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle condensed nuclear chromosome nucleus membrane-enclosed lumen intracellular membraneless organelle nuclear chromosome chromosome membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle condensed nuclear chromosome nucleus membrane-enclosed lumen intracellular membraneless organelle nuclear chromosome chromosome intracellular organelle lumen organelle lumen membraneless organelle condensed chromosome nuclear lumen chromosome, centromeric region chromosomal region protein-containing complex mitotic cohesin complex cohesin complex
A, B, C, D	STRUCTURAL MAINTENANCE OF CHROMOSOME 1	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding DNA binding nucleic acid binding double-stranded DNA binding DNA secondary structure binding minor groove of adenine-thymine-rich DNA binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity identical protein binding protein binding	cellular process cell division cellular component organization organelle organization mitotic sister chromatid cohesion chromosome organization sister chromatid cohesion cellular component organization or biogenesis cell cycle cell cycle process establishment of meiotic sister chromatid cohesion establishment of sister chromatid cohesion meiotic sister chromatid cohesion cellular response to stimulus cellular process cell division cellular component organization organelle organization mitotic sister chromatid cohesion chromosome organization sister chromatid cohesion cellular component organization or biogenesis cell cycle cell cycle process establishment of meiotic sister chromatid cohesion establishment of sister chromatid cohesion meiotic sister chromatid cohesion cellular response to stimulus double-strand break repair response to stimulus primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process cellular response to stress DNA damage response response to stress metabolic process macromolecule metabolic process DNA repair mitotic nuclear division organelle fission sister chromatid segregation mitotic cell cycle nuclear division mitotic cell cycle process mitotic sister chromatid segregation nuclear chromosome segregation chromosome segregation establishment of mitotic sister chromatid cohesion	intracellular organelle protein-containing complex cellular anatomical structure intracellular anatomical structure organelle membraneless organelle intracellular membraneless organelle chromosome cohesin complex meiotic cohesin complex mitotic cohesin complex membrane-bounded organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
E, F, G, H	IPR039781	Rad21/Rec8-like protein	Family
E, F, G, H	IPR006910	Rad21/Rec8-like protein, N-terminal	Domain
E, F, G, H	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
E, F, G, H	IPR023093	ScpA-like, C-terminal	Homologous Superfamily
E, F, G, H	IPR006909	Rad21/Rec8-like protein, C-terminal, eukaryotic	Domain
A, B, C, D	IPR010935	SMCs flexible hinge	Domain
A, B, C, D	IPR036277	SMCs flexible hinge superfamily	Homologous Superfamily
A, B, C, D	IPR003395	RecF/RecN/SMC, N-terminal	Domain
A, B, C, D	IPR024704	Structural maintenance of chromosomes protein	Family
A, B, C, D	IPR028468	Smc1, ATP-binding cassette domain	Domain
A, B, C, D	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.