Annotations: 1XEL

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1xela_	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Tyrosine-dependent oxidoreductases	Uridine diphosphogalactose-4-epimerase (UDP-galactose 4-epimerase)	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	SDR-like	8000694	3000038	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	GDP_Man_Dehyd	e1xelA1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: GDP_Man_Dehyd	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.90.25.10	Alpha Beta	Alpha-Beta Complex	UDP-galactose 4-epimerase	domain 1	CATH (4.3.0)
A	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF01370	NAD dependent epimerase/dehydratase family (Epimerase)	NAD dependent epimerase/dehydratase family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	UDP-GALACTOSE 4-EPIMERASE	NAD+ binding NAD binding binding nucleotide binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding heterocyclic compound binding small molecule binding isomerase activity racemase and epimerase activity NAD+ binding NAD binding binding nucleotide binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding heterocyclic compound binding small molecule binding isomerase activity racemase and epimerase activity racemase and epimerase activity, acting on carbohydrates and derivatives catalytic activity UDP-glucose 4-epimerase activity identical protein binding protein binding	carbohydrate metabolic process primary metabolic process metabolic process monosaccharide metabolic process hexose metabolic process small molecule metabolic process galactose metabolic process carbohydrate derivative biosynthetic process colanic acid metabolic process cellular biosynthetic process cellular metabolic process carbohydrate derivative metabolic process macromolecule biosynthetic process colanic acid biosynthetic process carbohydrate metabolic process primary metabolic process metabolic process monosaccharide metabolic process hexose metabolic process small molecule metabolic process galactose metabolic process carbohydrate derivative biosynthetic process colanic acid metabolic process cellular biosynthetic process cellular metabolic process carbohydrate derivative metabolic process macromolecule biosynthetic process colanic acid biosynthetic process biosynthetic process cellular process macromolecule metabolic process catabolic process hexose catabolic process carbohydrate catabolic process galactose catabolic process galactose catabolic process via UDP-galactose monosaccharide catabolic process small molecule catabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR005886	UDP-glucose 4-epimerase	Family
A	IPR036291	NAD(P)-binding domain superfamily	Homologous Superfamily
A	IPR001509	NAD-dependent epimerase/dehydratase	Domain

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

Chains	Enzyme Name	Description	Catalytic Residues
A	UDP-glucose 4-epimerase M-CSA #188	UDP-glucose 4-epimerase (EC:5.1.3.2) interconverts UDP-glucose and UDP-galactose which are precursors of glucose- and galactose-containing exopolysaccharides (EPS) via the transient reduction of NAD.	Defined by 3 residues: SER:A-124TYR:A-149LYS:A-153 \| Explore in 3D: M-CSA Motif Definition Search M-CSA Motif EC: 5.1.3.2 (PDB Primary Data) Search M-CSA Motif + EC 5.1.3.2

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.