1YH3
Crystal structure of human CD38 extracellular domain
External Resource: Annotation
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Chains | Domain Info | Class | Fold | Superfamily | Family | Domain | Species | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
B | d1yh3b_ | Alpha and beta proteins (a/b) | Flavodoxin-like | N-(deoxy)ribosyltransferase-like | ADP ribosyl cyclase-like | ADP ribosyl cyclase | human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
A | d1yh3a_ | Alpha and beta proteins (a/b) | Flavodoxin-like | N-(deoxy)ribosyltransferase-like | ADP ribosyl cyclase-like | ADP ribosyl cyclase | human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
B | Rib_hydrolayse | e1yh3B1 | A: a/b three-layered sandwiches | X: Flavodoxin-like | H: N-deoxyribosyltransferase (From Topology) | T: N-deoxyribosyltransferase | F: Rib_hydrolayse | ECOD (1.6) |
A | Rib_hydrolayse | e1yh3A1 | A: a/b three-layered sandwiches | X: Flavodoxin-like | H: N-deoxyribosyltransferase (From Topology) | T: N-deoxyribosyltransferase | F: Rib_hydrolayse | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
B | 1.20.82.10 | Mainly Alpha | Up-down Bundle | ADP Ribosyl Cyclase | Chain A, domain 1 | CATH (4.3.0) |
B | 3.40.50.720 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | NAD(P)-binding Rossmann-like Domain | CATH (4.3.0) |
A | 1.20.82.10 | Mainly Alpha | Up-down Bundle | ADP Ribosyl Cyclase | Chain A, domain 1 | CATH (4.3.0) |
A | 3.40.50.720 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | NAD(P)-binding Rossmann-like Domain | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF02267 | ADP-ribosyl cyclase (Rib_hydrolayse) | ADP-ribosyl cyclase | ADP-ribosyl cyclase EC:3.2.2.5 (also know as cyclic ADP-ribose hydrolase or CD38) synthesises cyclic-ADP ribose, a second messenger for glucose-induced insulin secretion. | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR003193 | ADP-ribosyl cyclase (CD38/157) | Family |