1YON
Escherichia coli ketopantoate reductase in complex with 2-monophosphoadenosine-5'-diphosphate
External Resource: Annotation
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Chains | Domain Info | Class | Fold | Superfamily | Family | Domain | Species | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | d1yona1 | All alpha proteins | 6-phosphogluconate dehydrogenase C-terminal domain-like | 6-phosphogluconate dehydrogenase C-terminal domain-like | Ketopantoate reductase PanE | Ketopantoate reductase PanE | (Escherichia coli ) [TaxId: 562 ], | SCOPe (2.08) |
A | d1yona2 | Alpha and beta proteins (a/b) | NAD(P)-binding Rossmann-fold domains | NAD(P)-binding Rossmann-fold domains | 6-phosphogluconate dehydrogenase-like, N-terminal domain | Ketopantoate reductase PanE | (Escherichia coli ) [TaxId: 562 ], | SCOPe (2.08) |
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | ApbA_C | e1yonA1 | A: alpha arrays | X: 6-phosphogluconate dehydrogenase C-terminal domain-like (From Topology) | H: 6-phosphogluconate dehydrogenase C-terminal domain-like (From Topology) | T: 6-phosphogluconate dehydrogenase C-terminal domain-like | F: ApbA_C | ECOD (1.6) |
A | ApbA | e1yonA2 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: NAD(P)-binding Rossmann-fold domains | F: ApbA | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A | 3.40.50.720 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | NAD(P)-binding Rossmann-like Domain | CATH (4.3.0) |
A | 1.10.1040.10 | Mainly Alpha | Orthogonal Bundle | N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase | domain 2 | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF02558 | Ketopantoate reductase PanE/ApbA (ApbA) | Ketopantoate reductase PanE/ApbA | - | Family | |
PF08546 | Ketopantoate reductase PanE/ApbA C terminal (ApbA_C) | Ketopantoate reductase PanE/ApbA C terminal | - | Family |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR003710 | Ketopantoate reductase ApbA/PanE | Family | |
IPR036291 | NAD(P)-binding domain superfamily | Homologous Superfamily | |
IPR013328 | 6-phosphogluconate dehydrogenase, domain 2 | Homologous Superfamily | |
IPR013752 | Ketopantoate reductase, C-terminal domain | Domain | |
IPR013332 | Ketopantoate reductase, N-terminal domain | Domain | |
IPR050838 | Ketopantoate reductase | Family | |
IPR008927 | 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily | Homologous Superfamily |
Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage
Chains | Enzyme Name | Description | Catalytic Residues |
---|---|---|---|
2-dehydropantoate 2-reductase M-CSA #721 | Ketopantoate reductase (KPR), isolated from Escherichia coli, catalyses the reduction of ketopantoate by NADPH to form pantoate and NADP+. This is the second reaction in the pathway for the biosynthesis of pantothenate (vitamin B5). KPR is a member of the 6-phosphogluconate dehydrogenase superfamily. The reaction proceeds by a sequential ordered bi:bi kinetic mechanism, with NADPH binding first, followed by a conformational change and the binding of ketopantoate. After the reaction NADP+ dissociates first, followed by pantoate. | EC: 1.1.1.169 (PDB Primary Data) |