1ZSX

Crystal Structure Of Human Potassium Channel Kv Beta-subunit (KCNAB2)

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1zsxa1	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	NAD(P)-linked oxidoreductase	Aldo-keto reductases (NADP)	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d1zsxa2	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Aldo_ket_red	e1zsxA1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Aldo_ket_red	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.20.20.100	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	NADP-dependent oxidoreductase domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00248	Aldo/keto reductase family (Aldo_ket_red)	Aldo/keto reductase family	This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Voltage-gated potassium channel beta-2 subunit	methylglyoxal reductase (NADPH) (acetol producing) activity oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor oxidoreductase activity, acting on CH-OH group of donors catalytic activity monoatomic cation transmembrane transporter activity gated channel activity monoatomic ion channel activity potassium ion transmembrane transporter activity voltage-gated channel activity voltage-gated monoatomic ion channel activity potassium channel activity voltage-gated monoatomic cation channel activity monoatomic cation channel activity methylglyoxal reductase (NADPH) (acetol producing) activity oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor oxidoreductase activity, acting on CH-OH group of donors catalytic activity monoatomic cation transmembrane transporter activity gated channel activity monoatomic ion channel activity potassium ion transmembrane transporter activity voltage-gated channel activity voltage-gated monoatomic ion channel activity potassium channel activity voltage-gated monoatomic cation channel activity monoatomic cation channel activity passive transmembrane transporter activity voltage-gated potassium channel activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity protein binding binding transmembrane transporter binding aldo-keto reductase (NADPH) activity alcohol dehydrogenase [NAD(P)+] activity potassium channel regulator activity channel regulator activity ion channel regulator activity molecular function regulator activity transporter regulator activity	protein localization regulation of localization cellular localization regulation of biological process regulation of cellular process regulation of protein localization biological regulation localization protein localization to cell surface regulation of cellular localization cellular macromolecule localization macromolecule localization regulation of protein localization to cell surface cellular process protein localization regulation of localization cellular localization regulation of biological process regulation of cellular process regulation of protein localization biological regulation localization protein localization to cell surface regulation of cellular localization cellular macromolecule localization macromolecule localization regulation of protein localization to cell surface cellular process regulation of action potential action potential regulation of biological quality regulation of membrane potential nucleoside phosphate metabolic process nicotinamide nucleotide metabolic process cellular metabolic process primary metabolic process nucleotide metabolic process purine-containing compound metabolic process NADP metabolic process nucleobase-containing compound metabolic process purine nucleotide metabolic process organophosphate metabolic process nucleobase-containing small molecule metabolic process phosphate-containing compound metabolic process pyridine-containing compound metabolic process metabolic process small molecule metabolic process NADPH oxidation phosphorus metabolic process pyridine nucleotide metabolic process regulation of potassium ion transport transport monoatomic ion transmembrane transport potassium ion transmembrane transport regulation of monoatomic ion transmembrane transport metal ion transport monoatomic cation transmembrane transport monoatomic ion transport monoatomic cation transport regulation of metal ion transport regulation of transport regulation of monoatomic ion transport inorganic ion transmembrane transport regulation of potassium ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport regulation of transmembrane transport potassium ion transport regulation of monoatomic cation transmembrane transport	membrane-bounded organelle intracellular anatomical structure tertiary granule membrane membrane intracellular vesicle cellular anatomical entity intracellular membrane-bounded organelle endomembrane system tertiary granule intracellular organelle cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane cytoplasmic vesicle membrane-bounded organelle intracellular anatomical structure tertiary granule membrane membrane intracellular vesicle cellular anatomical entity intracellular membrane-bounded organelle endomembrane system tertiary granule intracellular organelle cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane cytoplasmic vesicle organelle secretory granule secretory vesicle cytoplasm vesicle organelle membrane secretory granule membrane axon cell projection main axon juxtaparanode region of axon neuron projection plasma membrane bounded cell projection specific granule membrane specific granule cytosol cell periphery plasma membrane voltage-gated potassium channel complex protein-containing complex plasma membrane protein complex potassium channel complex membrane protein complex cation channel complex transporter complex transmembrane transporter complex monoatomic ion channel complex cytoskeleton intracellular non-membrane-bounded organelle non-membrane-bounded organelle synapse cell junction pinceau fiber cytoplasmic side of plasma membrane cytoplasmic side of membrane side of membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR005399	Potassium channel, voltage-dependent, beta subunit, KCNAB-related	Family
A	IPR036812	NADP-dependent oxidoreductase domain superfamily	Homologous Superfamily
A	IPR005401	Potassium channel, voltage-dependent, beta subunit, KCNAB2	Family
A	IPR023210	NADP-dependent oxidoreductase domain	Domain
A	IPR005983	Potassium channel, voltage-dependent, beta subunit, KCNAB	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q13303	chromosome 1p36 deletion syndrome epilepsy pilocytic astrocytoma acute myeloid leukemia Aura interstitial cystitis malignant ependymoma medulloblastoma osteosarcoma primitive neuroectodermal tumor astrocytic tumor large cell medulloblastoma malignant glioma non-small cell lung carcinoma Pick disease chromosome 1p36 deletion syndrome epilepsy pilocytic astrocytoma acute myeloid leukemia Aura interstitial cystitis malignant ependymoma medulloblastoma osteosarcoma primitive neuroectodermal tumor astrocytic tumor large cell medulloblastoma malignant glioma non-small cell lung carcinoma Pick disease atypical teratoid rhabdoid tumor glioblastoma lung cancer malignant mesothelioma oligodendroglioma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.