2AF6

Crystal structure of Mycobacterium tuberculosis Flavin dependent thymidylate synthase (Mtb ThyX) in the presence of co-factor FAD and substrate analog 5-Bromo-2'-Deoxyuridine-5'-Monophosphate (BrdUMP)

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Thy1	e2af6A1	A: a+b two layers	X: Thymidylate synthase-complementing protein Thy1 (From Topology)	H: Thymidylate synthase-complementing protein Thy1 (From Topology)	T: Thymidylate synthase-complementing protein Thy1	F: Thy1	ECOD (1.6)
B	Thy1	e2af6B1	A: a+b two layers	X: Thymidylate synthase-complementing protein Thy1 (From Topology)	H: Thymidylate synthase-complementing protein Thy1 (From Topology)	T: Thymidylate synthase-complementing protein Thy1	F: Thy1	ECOD (1.6)
C	Thy1	e2af6C1	A: a+b two layers	X: Thymidylate synthase-complementing protein Thy1 (From Topology)	H: Thymidylate synthase-complementing protein Thy1 (From Topology)	T: Thymidylate synthase-complementing protein Thy1	F: Thy1	ECOD (1.6)
D	Thy1	e2af6D1	A: a+b two layers	X: Thymidylate synthase-complementing protein Thy1 (From Topology)	H: Thymidylate synthase-complementing protein Thy1 (From Topology)	T: Thymidylate synthase-complementing protein Thy1	F: Thy1	ECOD (1.6)
E	Thy1	e2af6E1	A: a+b two layers	X: Thymidylate synthase-complementing protein Thy1 (From Topology)	H: Thymidylate synthase-complementing protein Thy1 (From Topology)	T: Thymidylate synthase-complementing protein Thy1	F: Thy1	ECOD (1.6)
F	Thy1	e2af6F1	A: a+b two layers	X: Thymidylate synthase-complementing protein Thy1 (From Topology)	H: Thymidylate synthase-complementing protein Thy1 (From Topology)	T: Thymidylate synthase-complementing protein Thy1	F: Thy1	ECOD (1.6)
G	Thy1	e2af6G1	A: a+b two layers	X: Thymidylate synthase-complementing protein Thy1 (From Topology)	H: Thymidylate synthase-complementing protein Thy1 (From Topology)	T: Thymidylate synthase-complementing protein Thy1	F: Thy1	ECOD (1.6)
H	Thy1	e2af6H1	A: a+b two layers	X: Thymidylate synthase-complementing protein Thy1 (From Topology)	H: Thymidylate synthase-complementing protein Thy1 (From Topology)	T: Thymidylate synthase-complementing protein Thy1	F: Thy1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Provenance Source (Version)
A	3.30.70.3180	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	CATH (4.3.0)
A	6.10.140.450	Special	Helix non-globular	Helix Hairpins	CATH (4.3.0)
A	6.10.140.440	Special	Helix non-globular	Helix Hairpins	CATH (4.3.0)
B	3.30.70.3180	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	CATH (4.3.0)
B	6.10.140.450	Special	Helix non-globular	Helix Hairpins	CATH (4.3.0)
B	6.10.140.440	Special	Helix non-globular	Helix Hairpins	CATH (4.3.0)
C	3.30.70.3180	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	CATH (4.3.0)
C	6.10.140.450	Special	Helix non-globular	Helix Hairpins	CATH (4.3.0)
C	6.10.140.440	Special	Helix non-globular	Helix Hairpins	CATH (4.3.0)
D	3.30.70.3180	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	CATH (4.3.0)
D	6.10.140.450	Special	Helix non-globular	Helix Hairpins	CATH (4.3.0)
D	6.10.140.440	Special	Helix non-globular	Helix Hairpins	CATH (4.3.0)
E	3.30.70.3180	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	CATH (4.3.0)
E	6.10.140.450	Special	Helix non-globular	Helix Hairpins	CATH (4.3.0)
E	6.10.140.440	Special	Helix non-globular	Helix Hairpins	CATH (4.3.0)
F	3.30.70.3180	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	CATH (4.3.0)
F	6.10.140.450	Special	Helix non-globular	Helix Hairpins	CATH (4.3.0)
F	6.10.140.440	Special	Helix non-globular	Helix Hairpins	CATH (4.3.0)
G	3.30.70.3180	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	CATH (4.3.0)
G	6.10.140.450	Special	Helix non-globular	Helix Hairpins	CATH (4.3.0)
G	6.10.140.440	Special	Helix non-globular	Helix Hairpins	CATH (4.3.0)
H	3.30.70.3180	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	CATH (4.3.0)
H	6.10.140.450	Special	Helix non-globular	Helix Hairpins	CATH (4.3.0)
H	6.10.140.440	Special	Helix non-globular	Helix Hairpins	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H	PF02511	Thymidylate synthase complementing protein (Thy1)	Thymidylate synthase complementing protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H	Thymidylate synthase thyX	binding nucleotide binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding heterocyclic compound binding NADPH binding NADP binding small molecule binding transferase activity, transferring one-carbon groups transferase activity binding nucleotide binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding heterocyclic compound binding NADPH binding NADP binding small molecule binding transferase activity, transferring one-carbon groups transferase activity methyltransferase activity thymidylate synthase activity 5,10-methylenetetrahydrofolate-dependent methyltransferase activity catalytic activity thymidylate synthase (FAD) activity flavin adenine dinucleotide binding	methylation metabolic process pyrimidine deoxyribonucleotide metabolic process deoxyribose phosphate biosynthetic process nucleotide biosynthetic process carbohydrate derivative metabolic process pyrimidine nucleotide metabolic process pyrimidine deoxyribonucleoside monophosphate metabolic process nucleobase-containing compound metabolic process deoxyribonucleotide biosynthetic process deoxyribonucleotide metabolic process pyrimidine deoxyribonucleotide biosynthetic process nucleobase-containing small molecule metabolic process dTMP metabolic process methylation metabolic process pyrimidine deoxyribonucleotide metabolic process deoxyribose phosphate biosynthetic process nucleotide biosynthetic process carbohydrate derivative metabolic process pyrimidine nucleotide metabolic process pyrimidine deoxyribonucleoside monophosphate metabolic process nucleobase-containing compound metabolic process deoxyribonucleotide biosynthetic process deoxyribonucleotide metabolic process pyrimidine deoxyribonucleotide biosynthetic process nucleobase-containing small molecule metabolic process dTMP metabolic process phosphate-containing compound metabolic process deoxyribonucleoside monophosphate biosynthetic process dTMP biosynthetic process small molecule metabolic process pyrimidine deoxyribonucleoside monophosphate biosynthetic process pyrimidine-containing compound biosynthetic process nucleoside monophosphate metabolic process phosphorus metabolic process nucleoside phosphate metabolic process carbohydrate derivative biosynthetic process pyrimidine nucleoside monophosphate metabolic process pyrimidine-containing compound metabolic process cellular metabolic process 2'-deoxyribonucleotide metabolic process 2'-deoxyribonucleotide biosynthetic process primary metabolic process nucleotide metabolic process deoxyribose phosphate metabolic process nucleobase-containing compound biosynthetic process deoxyribonucleoside monophosphate metabolic process nucleoside monophosphate biosynthetic process biosynthetic process organophosphate metabolic process organophosphate biosynthetic process nucleoside phosphate biosynthetic process cellular process pyrimidine nucleoside monophosphate biosynthetic process pyrimidine nucleotide biosynthetic process pyrimidine deoxyribonucleoside triphosphate biosynthetic process dTTP biosynthetic process pyrimidine deoxyribonucleoside triphosphate metabolic process pyrimidine nucleoside triphosphate biosynthetic process pyrimidine nucleoside triphosphate metabolic process dTTP metabolic process nucleoside triphosphate biosynthetic process nucleoside triphosphate metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H	IPR003669	Thymidylate synthase ThyX	Family
A, B, C, D, E A, B, C, D, E, F, G, H	IPR036098	Thymidylate synthase ThyX superfamily	Homologous Superfamily