2AF6

Crystal structure of Mycobacterium tuberculosis Flavin dependent thymidylate synthase (Mtb ThyX) in the presence of co-factor FAD and substrate analog 5-Bromo-2'-Deoxyuridine-5'-Monophosphate (BrdUMP)


Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AThy1e2af6A1 A: a+b two layersX: Thymidylate synthase-complementing protein Thy1 (From Topology)H: Thymidylate synthase-complementing protein Thy1 (From Topology)T: Thymidylate synthase-complementing protein Thy1F: Thy1ECOD (1.6)
BThy1e2af6B1 A: a+b two layersX: Thymidylate synthase-complementing protein Thy1 (From Topology)H: Thymidylate synthase-complementing protein Thy1 (From Topology)T: Thymidylate synthase-complementing protein Thy1F: Thy1ECOD (1.6)
CThy1e2af6C1 A: a+b two layersX: Thymidylate synthase-complementing protein Thy1 (From Topology)H: Thymidylate synthase-complementing protein Thy1 (From Topology)T: Thymidylate synthase-complementing protein Thy1F: Thy1ECOD (1.6)
DThy1e2af6D1 A: a+b two layersX: Thymidylate synthase-complementing protein Thy1 (From Topology)H: Thymidylate synthase-complementing protein Thy1 (From Topology)T: Thymidylate synthase-complementing protein Thy1F: Thy1ECOD (1.6)
EThy1e2af6E1 A: a+b two layersX: Thymidylate synthase-complementing protein Thy1 (From Topology)H: Thymidylate synthase-complementing protein Thy1 (From Topology)T: Thymidylate synthase-complementing protein Thy1F: Thy1ECOD (1.6)
FThy1e2af6F1 A: a+b two layersX: Thymidylate synthase-complementing protein Thy1 (From Topology)H: Thymidylate synthase-complementing protein Thy1 (From Topology)T: Thymidylate synthase-complementing protein Thy1F: Thy1ECOD (1.6)
GThy1e2af6G1 A: a+b two layersX: Thymidylate synthase-complementing protein Thy1 (From Topology)H: Thymidylate synthase-complementing protein Thy1 (From Topology)T: Thymidylate synthase-complementing protein Thy1F: Thy1ECOD (1.6)
HThy1e2af6H1 A: a+b two layersX: Thymidylate synthase-complementing protein Thy1 (From Topology)H: Thymidylate synthase-complementing protein Thy1 (From Topology)T: Thymidylate synthase-complementing protein Thy1F: Thy1ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.30.70.3180 Alpha Beta 2-Layer Sandwich Alpha-Beta Plaits CATH (4.3.0)
A6.10.140.450 Special Helix non-globular Helix Hairpins CATH (4.3.0)
A6.10.140.440 Special Helix non-globular Helix Hairpins CATH (4.3.0)
B3.30.70.3180 Alpha Beta 2-Layer Sandwich Alpha-Beta Plaits CATH (4.3.0)
B6.10.140.450 Special Helix non-globular Helix Hairpins CATH (4.3.0)
B6.10.140.440 Special Helix non-globular Helix Hairpins CATH (4.3.0)
C3.30.70.3180 Alpha Beta 2-Layer Sandwich Alpha-Beta Plaits CATH (4.3.0)
C6.10.140.450 Special Helix non-globular Helix Hairpins CATH (4.3.0)
C6.10.140.440 Special Helix non-globular Helix Hairpins CATH (4.3.0)
D3.30.70.3180 Alpha Beta 2-Layer Sandwich Alpha-Beta Plaits CATH (4.3.0)
D6.10.140.450 Special Helix non-globular Helix Hairpins CATH (4.3.0)
D6.10.140.440 Special Helix non-globular Helix Hairpins CATH (4.3.0)
E3.30.70.3180 Alpha Beta 2-Layer Sandwich Alpha-Beta Plaits CATH (4.3.0)
E6.10.140.450 Special Helix non-globular Helix Hairpins CATH (4.3.0)
E6.10.140.440 Special Helix non-globular Helix Hairpins CATH (4.3.0)
F3.30.70.3180 Alpha Beta 2-Layer Sandwich Alpha-Beta Plaits CATH (4.3.0)
F6.10.140.450 Special Helix non-globular Helix Hairpins CATH (4.3.0)
F6.10.140.440 Special Helix non-globular Helix Hairpins CATH (4.3.0)
G3.30.70.3180 Alpha Beta 2-Layer Sandwich Alpha-Beta Plaits CATH (4.3.0)
G6.10.140.450 Special Helix non-globular Helix Hairpins CATH (4.3.0)
G6.10.140.440 Special Helix non-globular Helix Hairpins CATH (4.3.0)
H3.30.70.3180 Alpha Beta 2-Layer Sandwich Alpha-Beta Plaits CATH (4.3.0)
H6.10.140.450 Special Helix non-globular Helix Hairpins CATH (4.3.0)
H6.10.140.440 Special Helix non-globular Helix Hairpins CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B, C, D, E
PF02511Thymidylate synthase complementing protein (Thy1)Thymidylate synthase complementing protein- Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B, C, D, E
Thymidylate synthase thyX -

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A, B, C, D, E
IPR003669Thymidylate synthase ThyXFamily
A, B, C, D, E
IPR036098Thymidylate synthase ThyX superfamilyHomologous Superfamily