2B50

Human Nuclear Receptor-Ligand Complex 2

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2b50a_	All alpha proteins	Nuclear receptor ligand-binding domain	Nuclear receptor ligand-binding domain	Nuclear receptor ligand-binding domain	Peroxisome proliferator-activated receptor delta, PPAR-DELTA	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d2b50b_	All alpha proteins	Nuclear receptor ligand-binding domain	Nuclear receptor ligand-binding domain	Nuclear receptor ligand-binding domain	Peroxisome proliferator-activated receptor delta, PPAR-DELTA	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Nuclear receptor ligand-binding domain	8038741	3001442	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Nuclear receptor ligand-binding domain	8038741	3001442	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Hormone_recep_1	e2b50A1	A: alpha arrays	X: Nuclear receptor ligand-binding domain (From Topology)	H: Nuclear receptor ligand-binding domain (From Topology)	T: Nuclear receptor ligand-binding domain	F: Hormone_recep_1	ECOD (1.6)
B	Hormone_recep_1	e2b50B1	A: alpha arrays	X: Nuclear receptor ligand-binding domain (From Topology)	H: Nuclear receptor ligand-binding domain (From Topology)	T: Nuclear receptor ligand-binding domain	F: Hormone_recep_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.565.10	Mainly Alpha	Orthogonal Bundle	Retinoid X Receptor	Retinoid X Receptor	CATH (4.3.0)
B	1.10.565.10	Mainly Alpha	Orthogonal Bundle	Retinoid X Receptor	Retinoid X Receptor	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00104	Ligand-binding domain of nuclear hormone receptor (Hormone_recep)	Ligand-binding domain of nuclear hormone receptor	This all helical domain is involved in binding the hormone in these receptors.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Peroxisome proliferator activated receptor delta	DNA binding binding organic cyclic compound binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity nuclear receptor activity molecular transducer activity ligand-activated transcription factor activity signaling receptor activity sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding DNA binding binding organic cyclic compound binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity nuclear receptor activity molecular transducer activity ligand-activated transcription factor activity signaling receptor activity sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding fatty acid binding linoleic acid binding organic acid binding long-chain fatty acid binding ion binding anion binding lipid binding carboxylic acid binding monocarboxylic acid binding small molecule binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription repressor activity RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding transcription cis-regulatory region binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding nuclear steroid receptor activity transcription factor binding transcription coregulator binding protein binding transcription coactivator binding DNA-binding transcription factor binding cation binding transition metal ion binding zinc ion binding metal ion binding	regulation of biological process cell population proliferation regulation of cellular process positive regulation of cell population proliferation biological regulation positive regulation of biological process fat cell proliferation regulation of cell population proliferation positive regulation of fat cell proliferation cellular process regulation of fat cell proliferation positive regulation of cellular process regulation of biosynthetic process regulation of macromolecule metabolic process regulation of biological process cell population proliferation regulation of cellular process positive regulation of cell population proliferation biological regulation positive regulation of biological process fat cell proliferation regulation of cell population proliferation positive regulation of fat cell proliferation cellular process regulation of fat cell proliferation positive regulation of cellular process regulation of biosynthetic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process positive regulation of macromolecule biosynthetic process regulation of gene expression positive regulation of metabolic process biosynthetic process positive regulation of gene expression positive regulation of biosynthetic process regulation of macromolecule biosynthetic process metabolic process positive regulation of macromolecule metabolic process macromolecule metabolic process regulation of metabolic process response to decreased oxygen levels cellular response to stimulus response to stimulus cellular response to oxygen levels cellular response to hypoxia cellular response to decreased oxygen levels cellular response to chemical stimulus cellular response to stress response to hypoxia response to stress response to chemical response to oxygen levels response to abiotic stimulus cellular response to nutrient levels response to nutrient levels apoptotic process cell death programmed cell death epithelial cell proliferation keratinocyte proliferation monosaccharide metabolic process carbohydrate metabolic process hexose metabolic process small molecule metabolic process primary metabolic process glucose metabolic process positive regulation of myoblast proliferation myoblast proliferation regulation of myoblast proliferation negative regulation of biological process RNA metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process transcription by RNA polymerase II negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of DNA-templated transcription negative regulation of RNA metabolic process developmental process fat cell differentiation positive regulation of fat cell differentiation regulation of developmental process cellular developmental process regulation of cell differentiation positive regulation of developmental process positive regulation of cell differentiation cell differentiation regulation of fat cell differentiation negative regulation of cell population proliferation regulation of epithelial cell proliferation negative regulation of epithelial cell proliferation positive regulation of DNA-templated transcription positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process multicellular organism development multicellular organismal process axon ensheathment ensheathment of neurons anatomical structure development nervous system development system development epithelium migration tissue migration ameboidal-type cell migration keratinocyte migration epithelial cell migration cell migration cell motility connective tissue development adipose tissue development animal organ development tissue development oxoacid metabolic process ketone metabolic process regulation of lipid metabolic process organic acid metabolic process regulation of small molecule metabolic process positive regulation of lipid metabolic process positive regulation of fatty acid metabolic process fatty acid metabolic process carboxylic acid metabolic process regulation of ketone metabolic process regulation of fatty acid metabolic process monocarboxylic acid metabolic process positive regulation of small molecule metabolic process lipid metabolic process signaling intracellular signal transduction cell communication intracellular signaling cassette signal transduction phosphatidylinositol 3-kinase/protein kinase B signal transduction lipid catabolic process catabolic process lipid modification organic acid catabolic process fatty acid catabolic process cellular catabolic process monocarboxylic acid catabolic process fatty acid oxidation carboxylic acid catabolic process fatty acid beta-oxidation lipid oxidation small molecule catabolic process cholesterol storage regulation of localization negative regulation of cholesterol storage lipid storage lipid localization negative regulation of lipid localization maintenance of location localization regulation of lipid storage regulation of lipid localization negative regulation of lipid storage macromolecule localization regulation of cholesterol storage negative regulation of developmental process muscle structure development negative regulation of myoblast differentiation regulation of myoblast differentiation negative regulation of cell differentiation myoblast differentiation response to endogenous stimulus hormone-mediated signaling pathway cellular response to endogenous stimulus response to hormone cellular response to hormone stimulus regulation of defense response regulation of response to external stimulus negative regulation of inflammatory response defense response negative regulation of response to stimulus response to external stimulus regulation of inflammatory response regulation of response to stimulus negative regulation of response to external stimulus regulation of response to stress negative regulation of defense response inflammatory response multicellular organismal-level homeostasis homeostatic process energy homeostasis generation of precursor metabolites and energy positive regulation of cell communication regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of signal transduction regulation of signal transduction positive regulation of response to stimulus regulation of intracellular signal transduction regulation of signaling positive regulation of intracellular signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction regulation of cell communication positive regulation of signaling organic hydroxy compound metabolic process sterol metabolic process steroid metabolic process cholesterol metabolic process alcohol metabolic process secondary alcohol metabolic process positive regulation of skeletal muscle tissue regeneration tissue regeneration regulation of growth skeletal muscle tissue regeneration developmental growth regeneration regulation of multicellular organismal process positive regulation of developmental growth regulation of multicellular organismal development regulation of developmental growth growth positive regulation of growth regulation of skeletal muscle tissue regeneration multi-multicellular organism process reproductive process female pregnancy embryo implantation multi-organism reproductive process organic anion transport carboxylic acid transport transport lipid transport establishment of localization organic acid transport monocarboxylic acid transport fatty acid transport negative regulation of miRNA transcription miRNA transcription regulation of miRNA metabolic process miRNA metabolic process negative regulation of miRNA metabolic process regulation of miRNA transcription placenta development maternal process involved in female pregnancy multicellular organismal reproductive process developmental process involved in reproduction maternal placenta development decidualization skeletal muscle satellite cell proliferation muscle cell proliferation regulation of skeletal muscle satellite cell proliferation skeletal muscle cell proliferation regulation of skeletal muscle cell proliferation striated muscle cell proliferation wound healing response to wounding apoptotic signaling pathway transmembrane transport hexose transmembrane transport D-glucose transmembrane transport carbohydrate transport monosaccharide transmembrane transport carbohydrate transmembrane transport cell adhesion cell-substrate adhesion	intracellular organelle cellular anatomical structure intracellular anatomical structure organelle membraneless organelle intracellular membraneless organelle chromatin chromosome membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm intracellular organelle cellular anatomical structure intracellular anatomical structure organelle membraneless organelle intracellular membraneless organelle chromatin chromosome membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR001628	Zinc finger, nuclear hormone receptor-type	Domain
A, B	IPR013088	Zinc finger, NHR/GATA-type	Homologous Superfamily
A, B	IPR003074	Peroxisome proliferator-activated receptor	Family
A, B	IPR050234	Nuclear hormone receptor family NR1 subfamily	Family
A, B	IPR003075	Peroxisome proliferator-activated receptor, beta	Family
A, B	IPR001723	Nuclear hormone receptor	Family
A, B	IPR000536	Nuclear hormone receptor, ligand-binding domain	Domain
A, B	IPR035500	Nuclear hormone receptor-like domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q03181	cardiomyopathy non-alcoholic fatty liver disease peripheral neuropathy skin cancer Cardiomegaly skin neoplasm obesity disorder peripheral nervous system disease alcoholic liver diseases melanoma ovarian cancer astrocytic tumor fatty liver disease pancreatic intraductal papillary-mucinous carcinoma psoriasis cardiomyopathy non-alcoholic fatty liver disease peripheral neuropathy skin cancer Cardiomegaly skin neoplasm obesity disorder peripheral nervous system disease alcoholic liver diseases melanoma ovarian cancer astrocytic tumor fatty liver disease pancreatic intraductal papillary-mucinous carcinoma psoriasis acute promyelocytic leukemia bipolar disorder large cell medulloblastoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.