2BHL

X-RAY STRUCTURE OF HUMAN GLUCOSE-6-PHOSPHATE DEHYDROGENASE (DELETION VARIANT) COMPLEXED WITH GLUCOSE-6-PHOSPHATE

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	GAPDH-like	8056151	3000043	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	GAPDH-like	8056151	3000043	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	G6PD_C	e2bhlA2	A: a+b two layers	X: FwdE/GAPDH domain-like	H: Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain (From Topology)	T: Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	F: G6PD_C	ECOD (1.6)
A	G6PD_N	e2bhlA1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: G6PD_N	ECOD (1.6)
B	G6PD_C	e2bhlB2	A: a+b two layers	X: FwdE/GAPDH domain-like	H: Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain (From Topology)	T: Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	F: G6PD_C	ECOD (1.6)
B	G6PD_N	e2bhlB1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: G6PD_N	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (4.3.0)
A	3.30.360.10	Alpha Beta	2-Layer Sandwich	Dihydrodipicolinate Reductase	domain 2	CATH (4.3.0)
B	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (4.3.0)
B	3.30.360.10	Alpha Beta	2-Layer Sandwich	Dihydrodipicolinate Reductase	domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00479	Glucose-6-phosphate dehydrogenase, NAD binding domain (G6PD_N)	Glucose-6-phosphate dehydrogenase, NAD binding domain	-	Domain
A, B	PF02781	Glucose-6-phosphate dehydrogenase, C-terminal domain (G6PD_C)	Glucose-6-phosphate dehydrogenase, C-terminal domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE	oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor oxidoreductase activity, acting on CH-OH group of donors catalytic activity glucose-6-phosphate dehydrogenase activity binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding adenyl nucleotide binding nucleotide binding heterocyclic compound binding NADP binding small molecule binding oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor oxidoreductase activity, acting on CH-OH group of donors catalytic activity glucose-6-phosphate dehydrogenase activity binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding adenyl nucleotide binding nucleotide binding heterocyclic compound binding NADP binding small molecule binding identical protein binding protein binding protein homodimerization activity protein dimerization activity D-glucose binding monosaccharide binding carbohydrate binding	regulation of biological process negative regulation of protein glutathionylation regulation of protein modification process regulation of protein metabolic process negative regulation of metabolic process biological regulation negative regulation of biological process primary metabolic process regulation of macromolecule metabolic process regulation of primary metabolic process regulation of protein glutathionylation macromolecule modification protein glutathionylation negative regulation of protein modification process regulation of biological process negative regulation of protein glutathionylation regulation of protein modification process regulation of protein metabolic process negative regulation of metabolic process biological regulation negative regulation of biological process primary metabolic process regulation of macromolecule metabolic process regulation of primary metabolic process regulation of protein glutathionylation macromolecule modification protein glutathionylation negative regulation of protein modification process metabolic process protein metabolic process macromolecule metabolic process protein modification process regulation of metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process multicellular organismal process regulation of growth system process regulation of cellular process negative regulation of muscle hypertrophy response to stimulus regulation of cardiac muscle tissue growth developmental growth regulation of system process negative regulation of muscle cell differentiation regulation of cell differentiation muscle cell differentiation regulation of muscle hypertrophy muscle structure development multicellular organism development muscle adaptation negative regulation of growth cell differentiation regulation of organ growth regulation of heart growth anatomical structure development cardiac muscle tissue growth muscle tissue development cardiac cell development system development developmental process heart growth negative regulation of striated muscle cell differentiation negative regulation of cell growth striated muscle hypertrophy tissue development negative regulation of developmental growth regulation of muscle cell differentiation regulation of response to stimulus striated muscle cell differentiation negative regulation of multicellular organismal process regulation of cellular component organization regulation of developmental process cellular developmental process cardiac muscle cell development cell development negative regulation of cell growth involved in cardiac muscle cell development regulation of striated muscle cell differentiation negative regulation of cardiac muscle tissue growth organ growth cell growth striated muscle tissue development cellular component organization negative regulation of organ growth striated muscle cell development muscle cell development cardiac muscle hypertrophy negative regulation of cellular process negative regulation of cell differentiation regulation of multicellular organismal process cellular component organization or biogenesis muscle hypertrophy regulation of muscle adaptation heart development regulation of multicellular organismal development regulation of developmental growth negative regulation of heart growth cardiac muscle tissue development developmental cell growth physiological muscle hypertrophy negative regulation of developmental process growth animal organ development cardiac muscle cell differentiation regulation of cell growth involved in cardiac muscle cell development regulation of cell growth regulation of muscle system process muscle system process regulation of cardiac muscle hypertrophy cardiocyte differentiation circulatory system development cell growth involved in cardiac muscle cell development physiological cardiac muscle hypertrophy cellular process negative regulation of cardiac muscle hypertrophy ribose phosphate metabolic process carbohydrate derivative biosynthetic process cellular metabolic process carbohydrate derivative metabolic process biosynthetic process organophosphate metabolic process organophosphate biosynthetic process phosphate-containing compound metabolic process ribose phosphate biosynthetic process phosphorus metabolic process nucleoside phosphate metabolic process nicotinamide nucleotide metabolic process generation of precursor metabolites and energy nucleotide metabolic process purine-containing compound metabolic process NADP metabolic process nucleobase-containing compound metabolic process NADPH regeneration purine nucleotide metabolic process nucleobase-containing small molecule metabolic process pyridine-containing compound metabolic process small molecule metabolic process pyridine nucleotide metabolic process regulation of localization regulation of calcium ion transport positive regulation of cation transmembrane transport positive regulation of calcium ion transport transport monoatomic ion transmembrane transport positive regulation of biological process regulation of monoatomic ion transmembrane transport calcium ion transport metal ion transport monoatomic cation transmembrane transport regulation of calcium ion transmembrane transport localization regulation of calcium ion transmembrane transport via high voltage-gated calcium channel positive regulation of monoatomic ion transport positive regulation of calcium ion transmembrane transport positive regulation of transmembrane transport monoatomic ion transport positive regulation of monoatomic ion transmembrane transport calcium ion transmembrane transport via high voltage-gated calcium channel monoatomic cation transport regulation of metal ion transport positive regulation of cellular process regulation of transport regulation of monoatomic ion transport inorganic ion transmembrane transport establishment of localization positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel inorganic cation transmembrane transport transmembrane transport regulation of transmembrane transport positive regulation of transport regulation of monoatomic cation transmembrane transport calcium ion transmembrane transport neuron apoptotic process regulation of apoptotic process regulation of programmed cell death cell death apoptotic process programmed cell death regulation of neuron apoptotic process glucose 6-phosphate metabolic process monosaccharide metabolic process carbohydrate metabolic process small molecule biosynthetic process carbohydrate biosynthetic process monosaccharide biosynthetic process pentose metabolic process pentose biosynthetic process lipid metabolic process response to iron(III) ion response to metal ion response to iron ion response to chemical glutathione metabolic process sulfur compound metabolic process amide metabolic process cellular modified amino acid metabolic process cellular response to stimulus response to oxidative stress cellular response to chemical stimulus cellular response to stress response to stress cellular response to oxidative stress cellular response to chemical stress secondary alcohol biosynthetic process cholesterol biosynthetic process organic hydroxy compound metabolic process sterol metabolic process steroid metabolic process cholesterol metabolic process lipid biosynthetic process alcohol metabolic process secondary alcohol metabolic process sterol biosynthetic process organic hydroxy compound biosynthetic process alcohol biosynthetic process steroid biosynthetic process hexose metabolic process glucose metabolic process response to alcohol response to oxygen-containing compound response to ethanol reactive oxygen species metabolic process regulation of cellular metabolic process negative regulation of cellular metabolic process negative regulation of reactive oxygen species metabolic process regulation of reactive oxygen species metabolic process head development brain development nervous system development substantia nigra development central nervous system development midbrain development neural nucleus development pentose-phosphate shunt pentose-phosphate shunt, oxidative branch response to organic cyclic compound erythrocyte development homeostatic process hemopoiesis erythrocyte maturation developmental maturation erythrocyte differentiation multicellular organismal-level homeostasis myeloid cell differentiation anatomical structure maturation immune system process myeloid cell development homeostasis of number of cells myeloid cell homeostasis cell maturation erythrocyte homeostasis response to nutrient levels response to food	membrane cellular anatomical entity extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure intracellular organelle centrosome membrane cellular anatomical entity extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure intracellular organelle centrosome microtubule organizing center cytoskeleton centriolar satellite intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle cytoplasm cytosol intracellular membrane-bounded organelle cell periphery cytoplasmic side of plasma membrane cytoplasmic side of membrane plasma membrane side of membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR019796	Glucose-6-phosphate dehydrogenase, active site	Active Site
A, B	IPR022674	Glucose-6-phosphate dehydrogenase, NAD-binding	Domain
A, B	IPR022675	Glucose-6-phosphate dehydrogenase, C-terminal	Domain
A, B	IPR001282	Glucose-6-phosphate dehydrogenase	Family
A, B	IPR036291	NAD(P)-binding domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P11413	G6PD deficiency congenital nonspherocytic hemolytic anemia favism chronic granulomatous disease hemolytic anemia malaria anemia, nonspherocytic hemolytic, due to G6PD deficiency familial hemolytic anemia phagocyte bactericidal dysfunction contact dermatitis Hemolysis inborn errors of metabolism acute kidney failure acute myeloid leukemia subependymal giant cell astrocytoma G6PD deficiency congenital nonspherocytic hemolytic anemia favism chronic granulomatous disease hemolytic anemia malaria anemia, nonspherocytic hemolytic, due to G6PD deficiency familial hemolytic anemia phagocyte bactericidal dysfunction contact dermatitis Hemolysis inborn errors of metabolism acute kidney failure acute myeloid leukemia subependymal giant cell astrocytoma cancer glioblastoma lung cancer anemia tuberculosis bipolar disorder granulomatous disease, chronic, X-linked invasive ductal breast carcinoma psoriasis breast cancer congenital anemia

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.