Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyRecA-like P-loop NTPases 8038341 3002019 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyRecA-like P-loop NTPases 8038342 3002019 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyRecA-like P-loop NTPases 8038341 3002019 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyRecA-like P-loop NTPases 8038342 3002019 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AEUF08000e2bhrA1 A: alpha arraysX: C-terminal helical domain of RNA helicase (From Topology)H: C-terminal helical domain of RNA helicase (From Topology)T: C-terminal helical domain of RNA helicaseF: EUF08000ECOD (1.6)
AFlavi_DEADe2bhrA2 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: Flavi_DEADECOD (1.6)
AHelicase_C_7e2bhrA3 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: Helicase_C_7ECOD (1.6)
BEUF08000e2bhrB1 A: alpha arraysX: C-terminal helical domain of RNA helicase (From Topology)H: C-terminal helical domain of RNA helicase (From Topology)T: C-terminal helical domain of RNA helicaseF: EUF08000ECOD (1.6)
BFlavi_DEADe2bhrB2 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: Flavi_DEADECOD (1.6)
BHelicase_C_7e2bhrB3 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: Helicase_C_7ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B
PF20907Flavivirus NS3 helicase, C-terminal helical domain (Flav_NS3-hel_C)Flavivirus NS3 helicase, C-terminal helical domainThis domain is found at the C-terminal end of NS3 helicase (Non- structural protein 3-helicase, NS3-Hel) found in Flavivirus such as Zika virus (ZIKV) and Dengue virus type 1 (DENV-1). This protein binds RNA and unwinds dsRNA in the 3' to 5' directio ...This domain is found at the C-terminal end of NS3 helicase (Non- structural protein 3-helicase, NS3-Hel) found in Flavivirus such as Zika virus (ZIKV) and Dengue virus type 1 (DENV-1). This protein binds RNA and unwinds dsRNA in the 3' to 5' direction. It consists of three domains. This entry represent the final domain, which is mostly alpha-helical [1,2]. A highly conserved R residue located in this domain was proven essential for the enzymatic activities of the protein [3].
Domain
A, B
PF07652Flavivirus DEAD domain (Flavi_DEAD)Flavivirus DEAD domain- Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B
RNA HELICASE

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A, B
IPR000208RNA-directed RNA polymerase, fingers/palm subdomains, flavivirusDomain
A, B
IPR014756Immunoglobulin E-setHomologous Superfamily
A, B
IPR001122Capsid protein C, flavivirusDomain
A, B
IPR027287Glycoprotein E, immunoglobulin-like domain, flavivirusDomain
A, B
IPR014412Genome polyprotein, FlavivirusFamily
A, B
IPR036253Flavivirus glycoprotein, central and dimerisation domain superfamilyHomologous Superfamily
A, B
IPR027417P-loop containing nucleoside triphosphate hydrolaseHomologous Superfamily
A, B
IPR026490mRNA cap 0/1 methyltransferaseDomain
A, B
IPR009003Peptidase S1, PA clanHomologous Superfamily
A, B
IPR001650Helicase, C-terminal domain-likeDomain
A, B
IPR014001Helicase superfamily 1/2, ATP-binding domainDomain
A, B
IPR013755Flaviviral glycoprotein E, central domain, subdomain 1Homologous Superfamily
A, B
IPR000752Flavivirus non-structural protein NS2ADomain
A, B
IPR047530RNA-dependent RNA polymerase, flavivirusDomain
A, B
IPR049486Flavivridae NS3 helicase, C-terminal helical domainDomain
A, B
IPR046811RNA-directed RNA polymerase, thumb subdomain, flavivirusDomain
A, B
IPR038055Flaviviral glycoprotein E, dimerisation domainHomologous Superfamily
A, B
IPR002877Ribosomal RNA methyltransferase, FtsJ domainDomain
A, B
IPR038302Envelope glycoprotein M superfamily, flavivirusHomologous Superfamily
A, B
IPR000069Envelope glycoprotein M, flavivirusDomain
A, B
IPR011492Non-structural protein NS3-like, DEAD box helicase, flavivirusDomain
A, B
IPR038345Flavivirus envelope glycoprotein E, Stem/Anchor domain superfamilyHomologous Superfamily
A, B
IPR038688Flavivirus polyprotein propeptide superfamilyHomologous Superfamily
A, B
IPR029063S-adenosyl-L-methionine-dependent methyltransferase superfamilyHomologous Superfamily
A, B
IPR026470Flavivirus envelope glycoprotein E, Stem/Anchor domainDomain
A, B
IPR011998Envelope glycoprotein E, central and dimerisation domain, flavivirusDomain
A, B
IPR043502DNA/RNA polymerase superfamilyHomologous Superfamily
A, B
IPR037172Flavivirus capsid protein C superfamilyHomologous Superfamily
A, B
IPR000404Flavivirus non-structural protein NS4ADomain
A, B
IPR000487Non-structural protein NS2B, flavivirusDomain
A, B
IPR001528Flavivirus non-structural protein NS4BDomain
A, B
IPR001157Non-structural protein NS1, flavivirusDomain
A, B
IPR013756Flaviviral glycoprotein E, central domain, subdomain 2Homologous Superfamily
A, B
IPR001850Non-structural protein NS3, peptidase S7, flavivirusDomain
A, B
IPR000336Flavivirus/Alphavirus glycoprotein, immunoglobulin-like domain superfamilyHomologous Superfamily
A, B
IPR002535Flavivirus polyprotein propeptideDomain
A, B
IPR043504Peptidase S1, PA clan, chymotrypsin-like foldHomologous Superfamily
A, B
IPR007094RNA-directed RNA polymerase, catalytic domainDomain