2BQ0

14-3-3 Protein Beta (Human)

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2bq0a_	All alpha proteins	alpha-alpha superhelix	14-3-3 protein	14-3-3 protein	automated matches	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d2bq0b_	All alpha proteins	alpha-alpha superhelix	14-3-3 protein	14-3-3 protein	automated matches	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	14-3-3 protein	8082807	3001329	SCOP2B (2022-06-29)
B	SCOP2 Family	14-3-3 protein	8082806	4001338	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	14-3-3 protein	8082807	3001329	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	14-3-3	e2bq0A1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: 14-3-3	ECOD (1.6)
B	14-3-3	e2bq0B1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: 14-3-3	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.190.20	Mainly Alpha	Up-down Bundle	Delta-Endotoxin	domain 1	CATH (4.3.0)
B	1.20.190.20	Mainly Alpha	Up-down Bundle	Delta-Endotoxin	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00244	14-3-3 protein (14-3-3)	14-3-3 protein	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	14-3-3 BETA/ALPHA	protein binding binding protein domain specific binding enzyme regulator activity protein kinase inhibitor activity molecular function inhibitor activity molecular function regulator activity enzyme inhibitor activity protein kinase regulator activity kinase inhibitor activity kinase regulator activity phosphoprotein binding phosphoserine residue binding protein phosphorylated amino acid binding protein binding binding protein domain specific binding enzyme regulator activity protein kinase inhibitor activity molecular function inhibitor activity molecular function regulator activity enzyme inhibitor activity protein kinase regulator activity kinase inhibitor activity kinase regulator activity phosphoprotein binding phosphoserine residue binding protein phosphorylated amino acid binding histone deacetylase binding enzyme binding cell adhesion molecule binding cadherin binding identical protein binding	protein localization localization cellular localization cellular macromolecule localization macromolecule localization cellular process maintenance of protein location cytoplasmic sequestering of protein maintenance of location cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling protein localization localization cellular localization cellular macromolecule localization macromolecule localization cellular process maintenance of protein location cytoplasmic sequestering of protein maintenance of location cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation signal transduction cell communication establishment of protein localization protein targeting establishment of localization regulation of signaling negative regulation of signaling negative regulation of response to stimulus negative regulation of biological process regulation of signal transduction negative regulation of signal transduction negative regulation of G protein-coupled receptor signaling pathway negative regulation of cell communication regulation of response to stimulus negative regulation of cellular process regulation of cell communication G protein-coupled receptor signaling pathway regulation of G protein-coupled receptor signaling pathway positive regulation of molecular function regulation of molecular function regulation of catalytic activity positive regulation of catalytic activity	cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction membrane membrane-bounded organelle intracellular anatomical structure pigment granule intracellular vesicle intracellular membrane-bounded organelle intracellular organelle melanosome cytoplasmic vesicle cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction membrane membrane-bounded organelle intracellular anatomical structure pigment granule intracellular vesicle intracellular membrane-bounded organelle intracellular organelle melanosome cytoplasmic vesicle organelle cytoplasm vesicle extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space extracellular membrane-bounded organelle cytosol perinuclear region of cytoplasm vacuolar membrane vacuole bounding membrane of organelle organelle membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR023409	14-3-3 protein, conserved site	Conserved Site
A, B	IPR023410	14-3-3 domain	Domain
A, B	IPR036815	14-3-3 domain superfamily	Homologous Superfamily
A, B	IPR000308	14-3-3 protein	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P31946	pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia astrocytic tumor dermatomyositis glioblastoma limb-girdle muscular dystrophy malignant colon neoplasm medulloblastoma pancreatic ductal adenocarcinoma Parkinson disease atypical teratoid rhabdoid tumor diabetes mellitus juvenile dermatomyositis lung adenocarcinoma malignant glioma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia astrocytic tumor dermatomyositis glioblastoma limb-girdle muscular dystrophy malignant colon neoplasm medulloblastoma pancreatic ductal adenocarcinoma Parkinson disease atypical teratoid rhabdoid tumor diabetes mellitus juvenile dermatomyositis lung adenocarcinoma malignant glioma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm bipolar disorder endogenous depression large cell medulloblastoma lymphoplasmacytic lymphoma malignant pancreatic neoplasm ovarian cancer

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.