2BWG
Structure of human guanosine monophosphate reductase GMPR1 in complex with GMP
External Resource: Annotation
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Chains | Domain Info | Class | Fold | Superfamily | Family | Domain | Species | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | d2bwga_ | Alpha and beta proteins (a/b) | TIM beta/alpha-barrel | Inosine monophosphate dehydrogenase (IMPDH) | automated matches | automated matches | (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
B | d2bwgb_ | Alpha and beta proteins (a/b) | TIM beta/alpha-barrel | Inosine monophosphate dehydrogenase (IMPDH) | automated matches | automated matches | (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
C | d2bwgc_ | Alpha and beta proteins (a/b) | TIM beta/alpha-barrel | Inosine monophosphate dehydrogenase (IMPDH) | automated matches | automated matches | (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
D | d2bwgd_ | Alpha and beta proteins (a/b) | TIM beta/alpha-barrel | Inosine monophosphate dehydrogenase (IMPDH) | automated matches | automated matches | (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
A | SCOP2 Family | Inosine monophosphate dehydrogenase (IMPDH) | 8081558 | 4003103 | SCOP2 (2022-06-29) |
A | SCOP2 Superfamily | Inosine monophosphate dehydrogenase (IMPDH) | 8081559 | 3000263 | SCOP2 (2022-06-29) |
B | SCOP2B Superfamily | Inosine monophosphate dehydrogenase (IMPDH) | 8081559 | 3000263 | SCOP2B (2022-06-29) |
C | SCOP2B Superfamily | Inosine monophosphate dehydrogenase (IMPDH) | 8081559 | 3000263 | SCOP2B (2022-06-29) |
D | SCOP2B Superfamily | Inosine monophosphate dehydrogenase (IMPDH) | 8081559 | 3000263 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | IMPDH_1st | e2bwgA1 | A: a/b barrels | X: TIM beta/alpha-barrel | H: TIM barrels (From Topology) | T: TIM barrels | F: IMPDH_1st | ECOD (1.6) |
B | IMPDH_1st | e2bwgB1 | A: a/b barrels | X: TIM beta/alpha-barrel | H: TIM barrels (From Topology) | T: TIM barrels | F: IMPDH_1st | ECOD (1.6) |
C | IMPDH_1st | e2bwgC1 | A: a/b barrels | X: TIM beta/alpha-barrel | H: TIM barrels (From Topology) | T: TIM barrels | F: IMPDH_1st | ECOD (1.6) |
D | IMPDH_1st | e2bwgD1 | A: a/b barrels | X: TIM beta/alpha-barrel | H: TIM barrels (From Topology) | T: TIM barrels | F: IMPDH_1st | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A | 3.20.20.70 | Alpha Beta | Alpha-Beta Barrel | TIM Barrel | Aldolase class I | CATH (4.3.0) |
B | 3.20.20.70 | Alpha Beta | Alpha-Beta Barrel | TIM Barrel | Aldolase class I | CATH (4.3.0) |
C | 3.20.20.70 | Alpha Beta | Alpha-Beta Barrel | TIM Barrel | Aldolase class I | CATH (4.3.0) |
D | 3.20.20.70 | Alpha Beta | Alpha-Beta Barrel | TIM Barrel | Aldolase class I | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF00478 | IMP dehydrogenase / GMP reductase domain (IMPDH) | IMP dehydrogenase / GMP reductase domain | This family is involved in biosynthesis of guanosine nucleotide. Members of this family contain a TIM barrel structure. In the inosine monophosphate dehydrogenases 2 CBS domains Pfam:PF00571 are inserted in the TIM barrel [2]. This family is a membe ... | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR050139 | Guanosine monophosphate reductase | Family | |
IPR005993 | GMP reductase | Family | |
IPR001093 | IMP dehydrogenase/GMP reductase | Domain | |
IPR013785 | Aldolase-type TIM barrel | Homologous Superfamily | |
IPR015875 | IMP dehydrogenase / GMP reductase, conserved site | Conserved Site |