2DA0

Solution structure of the PH domain of PIP2-dependent ARF1 GTPase-activating protein from human

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Membrane Protein Annotation: OPM

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Pleckstrin-homology domain (PH domain)	8087018	4002395	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	PH domain-like	8087019	3000134	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PH	e2da0A1	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: PH	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.30.29.30	Mainly Beta	Roll	PH-domain like	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00169	PH domain (PH)	PH domain	PH stands for pleckstrin homology.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	130-kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase-activating protein	GTPase regulator activity enzyme regulator activity enzyme activator activity GTPase activator activity molecular function activator activity nucleoside-triphosphatase regulator activity molecular function regulator activity binding ion binding phosphatidylinositol-4,5-bisphosphate binding anion binding phosphatidylinositol bisphosphate binding phospholipid binding lipid binding GTPase regulator activity enzyme regulator activity enzyme activator activity GTPase activator activity molecular function activator activity nucleoside-triphosphatase regulator activity molecular function regulator activity binding ion binding phosphatidylinositol-4,5-bisphosphate binding anion binding phosphatidylinositol bisphosphate binding phospholipid binding lipid binding phosphatidylinositol phosphate binding phosphatidylinositol binding small molecule binding cell adhesion molecule binding cadherin binding protein binding phosphatidylinositol-3,4,5-trisphosphate binding cation binding metal ion binding modified amino acid binding phosphatidylserine binding	multicellular organismal process regulation of developmental process cellular developmental process cell projection organization negative regulation of biological process cell development negative regulation of dendritic spine development regulation of dendritic spine development neuron projection development cellular component organization neurogenesis multicellular organism development neuron differentiation dendrite development cell differentiation multicellular organismal process regulation of developmental process cellular developmental process cell projection organization negative regulation of biological process cell development negative regulation of dendritic spine development regulation of dendritic spine development neuron projection development cellular component organization neurogenesis multicellular organism development neuron differentiation dendrite development cell differentiation anatomical structure development cellular component organization or biogenesis system development developmental process dendritic spine development regulation of biological process plasma membrane bounded cell projection organization negative regulation of developmental process biological regulation nervous system development generation of neurons neuron development cellular process protein localization Golgi to plasma membrane transport establishment of protein localization cellular localization nitrogen compound transport post-Golgi vesicle-mediated transport transport establishment of protein localization to plasma membrane Golgi to plasma membrane protein transport vesicle-mediated transport localization cellular macromolecule localization protein localization to cell periphery establishment of protein localization to membrane protein localization to plasma membrane localization within membrane protein localization to membrane establishment of localization vesicle-mediated transport to the plasma membrane protein transport macromolecule localization Golgi vesicle transport protein localization to cilium protein localization to organelle plasma membrane tubulation membrane organization positive regulation of cellular component organization regulation of cellular process regulation of cellular component organization positive regulation of biological process positive regulation of membrane tubulation regulation of plasma membrane organization plasma membrane organization endomembrane system organization positive regulation of cellular process regulation of membrane tubulation organelle assembly plasma membrane bounded cell projection assembly cellular component biogenesis organelle organization cellular component assembly cilium assembly cilium organization cell projection assembly positive regulation of organelle organization positive regulation of cell projection organization positive regulation of cellular component biogenesis regulation of cell projection organization regulation of cell projection assembly regulation of cellular component biogenesis regulation of organelle organization regulation of plasma membrane bounded cell projection assembly positive regulation of cilium assembly regulation of cilium assembly regulation of organelle assembly regulation of plasma membrane bounded cell projection organization positive regulation of plasma membrane bounded cell projection assembly positive regulation of organelle assembly postsynapse organization regulation of postsynapse organization regulation of synapse organization cell junction organization regulation of synapse structure or activity synapse organization regulation of biological quality	intracellular organelle cellular anatomical structure intracellular anatomical structure podosome cytoskeleton organelle membraneless organelle intracellular membraneless organelle actin cytoskeleton cytoplasm cytosol synapse cell junction glutamatergic synapse intracellular organelle cellular anatomical structure intracellular anatomical structure podosome cytoskeleton organelle membraneless organelle intracellular membraneless organelle actin cytoskeleton cytoplasm cytosol synapse cell junction glutamatergic synapse membrane-bounded organelle Golgi membrane Golgi apparatus membrane intracellular membrane-bounded organelle endomembrane system bounding membrane of organelle organelle membrane neuron spine neuron projection dendritic spine plasma membrane bounded cell projection somatodendritic compartment cell projection postsynapse dendrite dendritic tree Golgi apparatus subcompartment organelle subcompartment trans-Golgi network membrane trans-Golgi network

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR004148	BAR domain	Domain
A	IPR001849	Pleckstrin homology domain	Domain
A	IPR036770	Ankyrin repeat-containing domain superfamily	Homologous Superfamily
A	IPR036028	SH3-like domain superfamily	Homologous Superfamily
A	IPR027267	AH/BAR domain superfamily	Homologous Superfamily
A	IPR038016	ASAP1, SH3 domain	Domain
A	IPR011993	PH-like domain superfamily	Homologous Superfamily
A	IPR043593	Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein	Family
A	IPR038508	ArfGAP domain superfamily	Homologous Superfamily
A	IPR002110	Ankyrin repeat	Repeat
A	IPR037928	ASAP1, BAR domain	Domain
A	IPR001452	SH3 domain	Domain
A	IPR037844	ASAP, PH domain	Domain
A	IPR037278	ARFGAP/RecO-like zinc finger	Homologous Superfamily
A	IPR001164	Arf GTPase activating protein	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q9ULH1	pulmonary tuberculosis urinary bladder cancer astrocytic tumor Emery-Dreifuss muscular dystrophy juvenile idiopathic arthritis ovarian cancer rheumatoid arthritis subependymal giant cell astrocytoma breast cancer gastric carcinoma malignant pancreatic neoplasm pancreatic ductal adenocarcinoma sarcoidosis tuberculosis urinary bladder neoplasm pulmonary tuberculosis urinary bladder cancer astrocytic tumor Emery-Dreifuss muscular dystrophy juvenile idiopathic arthritis ovarian cancer rheumatoid arthritis subependymal giant cell astrocytoma breast cancer gastric carcinoma malignant pancreatic neoplasm pancreatic ductal adenocarcinoma sarcoidosis tuberculosis urinary bladder neoplasm Duchenne muscular dystrophy juvenile dermatomyositis myopathy Sjogren syndrome ulcerative colitis

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A	OPM	Monotopic/peripheral	All beta monotopic/peripheral	PH domain-like	Pleckstrin-homology domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.