2DDH

Crystal Structure of Acyl-CoA oxidase complexed with 3-OH-dodecanoate

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2ddha1	All alpha proteins	Bromodomain-like	Acyl-CoA dehydrogenase C-terminal domain-like	acyl-CoA oxidase C-terminal domains	Peroxisomal acyl-CoA oxidase-II, domains 3 and 4	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
A	d2ddha3	Multi-domain proteins (alpha and beta)	Acyl-CoA dehydrogenase NM domain-like	Acyl-CoA dehydrogenase NM domain-like	acyl-CoA oxidase N-terminal domains	Peroxisomal acyl-CoA oxidase-II, domains 1 and 2	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Acyl-CoA dehydrogenase C-terminal domain-like	8039692	3001580	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Acyl-CoA dehydrogenase C-terminal domain-like	8039695	3001580	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Acyl-CoA dehydrogenase N-terminal lobe-like	8039697	3001701	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Acyl-CoA_dh_M	e2ddhA1	A: beta complex topology	X: Acyl-CoA dehydrogenase middle domain-like (From Topology)	H: Acyl-CoA dehydrogenase middle domain-like (From Topology)	T: Acyl-CoA dehydrogenase middle domain-like	F: Acyl-CoA_dh_M	ECOD (1.6)
A	Acyl-CoA_ox_N	e2ddhA2	A: alpha arrays	X: Acyl-CoA dehydrogenase N-terminal domain-like (From Topology)	H: Acyl-CoA dehydrogenase N-terminal domain-like (From Topology)	T: Acyl-CoA dehydrogenase N-terminal domain-like	F: Acyl-CoA_ox_N	ECOD (1.6)
A	ACOX	e2ddhA4	A: alpha bundles	X: Bromodomain-like	H: Acyl-CoA dehydrogenase C-terminal domain-like (From Topology)	T: Acyl-CoA dehydrogenase C-terminal domain-like	F: ACOX	ECOD (1.6)
A	Acyl-CoA_dh_1	e2ddhA3	A: alpha bundles	X: Bromodomain-like	H: Acyl-CoA dehydrogenase C-terminal domain-like (From Topology)	T: Acyl-CoA dehydrogenase C-terminal domain-like	F: Acyl-CoA_dh_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.540.10	Mainly Alpha	Orthogonal Bundle	Butyryl-Coa Dehydrogenase, subunit A	domain 1	CATH (4.3.0)
A	2.40.110.10	Mainly Beta	Beta Barrel	Butyryl-CoA Dehydrogenase, subunit A	domain 2	CATH (4.3.0)
A	1.20.140.10	Mainly Alpha	Up-down Bundle	Butyryl-CoA Dehydrogenase, subunit A	domain 3	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF01756	Acyl-CoA oxidase (ACOX)	Acyl-CoA oxidase	-	Family
A	PF14749	Acyl-coenzyme A oxidase N-terminal (Acyl-CoA_ox_N)	Acyl-coenzyme A oxidase N-terminal	Acyl-coenzyme A oxidase consists of three domains. An N-terminal alpha-helical domain, a beta sheet domain (Pfam:PF02770) and a C-terminal catalytic domain (Pfam:PF01756). This entry represents the N-terminal alpha-helical domain [1].	Domain
A	PF02770	Acyl-CoA dehydrogenase, middle domain (Acyl-CoA_dh_M)	Acyl-CoA dehydrogenase, middle domain	Central domain of Acyl-CoA dehydrogenase has a beta-barrel fold.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Acyl-CoA oxidase	oxidoreductase activity acyl-CoA oxidase activity oxidoreductase activity, acting on the CH-CH group of donors catalytic activity oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor FAD binding flavin adenine dinucleotide binding binding nucleoside phosphate binding ion binding organic cyclic compound binding anion binding nucleotide binding heterocyclic compound binding oxidoreductase activity acyl-CoA oxidase activity oxidoreductase activity, acting on the CH-CH group of donors catalytic activity oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor FAD binding flavin adenine dinucleotide binding binding nucleoside phosphate binding ion binding organic cyclic compound binding anion binding nucleotide binding heterocyclic compound binding small molecule binding protein binding PDZ domain binding protein domain specific binding fatty acid binding organic acid binding lipid binding carboxylic acid binding monocarboxylic acid binding identical protein binding protein homodimerization activity protein dimerization activity palmitoyl-CoA oxidase activity	developmental process spermatogenesis sexual reproduction reproductive process multicellular organismal reproductive process developmental process involved in reproduction male gamete generation gamete generation catabolic process oxoacid metabolic process organic acid catabolic process organic acid metabolic process cellular lipid catabolic process cellular catabolic process developmental process spermatogenesis sexual reproduction reproductive process multicellular organismal reproductive process developmental process involved in reproduction male gamete generation gamete generation catabolic process oxoacid metabolic process organic acid catabolic process organic acid metabolic process cellular lipid catabolic process cellular catabolic process fatty acid beta-oxidation using acyl-CoA oxidase monocarboxylic acid catabolic process fatty acid oxidation carboxylic acid catabolic process fatty acid beta-oxidation small molecule metabolic process lipid oxidation fatty acid metabolic process lipid catabolic process cellular metabolic process carboxylic acid metabolic process primary metabolic process lipid modification fatty acid catabolic process cellular lipid metabolic process metabolic process cellular process monocarboxylic acid metabolic process small molecule catabolic process lipid metabolic process chemical homeostasis homeostatic process lipid homeostasis prostaglandin metabolic process icosanoid metabolic process unsaturated fatty acid metabolic process prostanoid metabolic process very long-chain fatty acid metabolic process very long-chain fatty acid beta-oxidation very long-chain fatty acid catabolic process generation of precursor metabolites and energy reactive oxygen species biosynthetic process biosynthetic process cellular biosynthetic process reactive oxygen species metabolic process hydrogen peroxide metabolic process hydrogen peroxide biosynthetic process	intracellular anatomical structure cytoplasm cellular anatomical entity membrane-bounded organelle intracellular organelle organelle peroxisome microbody intracellular membrane-bounded organelle membrane microbody membrane bounding membrane of organelle peroxisomal membrane organelle membrane intracellular anatomical structure cytoplasm cellular anatomical entity membrane-bounded organelle intracellular organelle organelle peroxisome microbody intracellular membrane-bounded organelle membrane microbody membrane bounding membrane of organelle peroxisomal membrane organelle membrane peroxisomal matrix membrane-enclosed lumen intracellular organelle lumen organelle lumen microbody lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR006091	Acyl-CoA oxidase/dehydrogenase, middle domain	Domain
A	IPR036250	Acyl-CoA dehydrogenase-like, C-terminal	Homologous Superfamily
A	IPR037069	Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily	Homologous Superfamily
A	IPR009100	Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily	Homologous Superfamily
A	IPR012258	Acyl-CoA oxidase	Family
A	IPR002655	Acyl-CoA oxidase, C-terminal	Domain
A	IPR034171	Peroxisomal acyl-coenzyme A oxidase	Family
A	IPR029320	Acyl-coenzyme A oxidase, N-terminal	Domain
A	IPR046373	Acyl-CoA oxidase/dehydrogenase, middle domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.