2DFU

Crystal structure of the 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase from Thermus Thermophilus HB8

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	FAH	8052518	3001446	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	FAH N-terminal domain-like	8052516	3001866	SCOP2B (2022-06-29)
B	SCOP2 Family	Cg1458 N-terminal domain-like	8044764	4004122	SCOP2 (2022-06-29)
B	SCOP2 Family	FAH	8052517	4002580	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	FAH N-terminal domain-like	8052516	3001866	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	FAH	8052518	3001446	SCOP2 (2022-06-29)
C	SCOP2B Superfamily	FAH	8052518	3001446	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	FAH N-terminal domain-like	8052516	3001866	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	FAH N-terminal domain-like	8052516	3001866	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	FAH	8052518	3001446	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	FAA_hydrolase	e2dfuA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: FAH (From Topology)	T: FAH	F: FAA_hydrolase	ECOD (1.6)
B	FAA_hydrolase	e2dfuB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: FAH (From Topology)	T: FAH	F: FAA_hydrolase	ECOD (1.6)
C	FAA_hydrolase	e2dfuC1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: FAH (From Topology)	T: FAH	F: FAA_hydrolase	ECOD (1.6)
D	FAA_hydrolase	e2dfuD1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: FAH (From Topology)	T: FAH	F: FAA_hydrolase	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.30.30.370	Mainly Beta	Roll	SH3 type barrels.	FAH	CATH (4.3.0)
A	3.90.850.10	Alpha Beta	Alpha-Beta Complex	Fumarylacetoacetate hydrolase	domain 2	CATH (4.3.0)
B	2.30.30.370	Mainly Beta	Roll	SH3 type barrels.	FAH	CATH (4.3.0)
B	3.90.850.10	Alpha Beta	Alpha-Beta Complex	Fumarylacetoacetate hydrolase	domain 2	CATH (4.3.0)
C	2.30.30.370	Mainly Beta	Roll	SH3 type barrels.	FAH	CATH (4.3.0)
C	3.90.850.10	Alpha Beta	Alpha-Beta Complex	Fumarylacetoacetate hydrolase	domain 2	CATH (4.3.0)
D	2.30.30.370	Mainly Beta	Roll	SH3 type barrels.	FAH	CATH (4.3.0)
D	3.90.850.10	Alpha Beta	Alpha-Beta Complex	Fumarylacetoacetate hydrolase	domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF01557	Fumarylacetoacetate (FAA) hydrolase family (FAA_hydrolase)	Fumarylacetoacetate (FAA) hydrolase family	-	Family
A, B, C, D	PF10370	Rv2993c-like, N-terminal (Rv2993c-like_N)	Rv2993c-like, N-terminal	This is the N-terminal 50 amino acids of a group of bacterial proteins annotated as fumarylacetoacetate hydrolase-containing enzymes, including Rv2993c from Mycobacterium tuberculosis. In most cases members are associated with FAA_hydrolase Pfam:PF01 ...	This is the N-terminal 50 amino acids of a group of bacterial proteins annotated as fumarylacetoacetate hydrolase-containing enzymes, including Rv2993c from Mycobacterium tuberculosis. In most cases members are associated with FAA_hydrolase Pfam:PF01557 further towards the C-terminus.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	probable 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase	isomerase activity catalytic activity cation binding ion binding binding metal ion binding small molecule binding	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR036663	Fumarylacetoacetase-like, C-terminal domain superfamily	Homologous Superfamily
A, B, C, D	IPR011234	Fumarylacetoacetase-like, C-terminal	Domain
A, B, C, D	IPR018833	Rv2993c-like, N-terminal	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.