2FK0

Crystal Structure of a H5N1 influenza virus hemagglutinin.

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d2fk0b1	Coiled coil proteins	Stalk segment of viral fusion proteins	Influenza hemagglutinin (stalk)	Influenza hemagglutinin (stalk)	Influenza hemagglutinin (stalk)	(Influenza A virus (A/Viet Nam/1203/2004(H5N1)) ) [TaxId: 284218 ],	SCOPe (2.08)
B	d2fk0b2	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Influenza A virus (A/Viet Nam/1203/2004(H5N1)) ) [TaxId: 284218 ],	SCOPe (2.08)
D	d2fk0d2	Coiled coil proteins	Stalk segment of viral fusion proteins	Influenza hemagglutinin (stalk)	Influenza hemagglutinin (stalk)	Influenza hemagglutinin (stalk)	(Influenza A virus (A/Viet Nam/1203/2004(H5N1)) ) [TaxId: 284218 ],	SCOPe (2.08)
D	d2fk0d3	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Influenza A virus (A/Viet Nam/1203/2004(H5N1)) ) [TaxId: 284218 ],	SCOPe (2.08)
F	d2fk0f2	Coiled coil proteins	Stalk segment of viral fusion proteins	Influenza hemagglutinin (stalk)	Influenza hemagglutinin (stalk)	Influenza hemagglutinin (stalk)	(Influenza A virus (A/Viet Nam/1203/2004(H5N1)) ) [TaxId: 284218 ],	SCOPe (2.08)
F	d2fk0f3	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Influenza A virus (A/Viet Nam/1203/2004(H5N1)) ) [TaxId: 284218 ],	SCOPe (2.08)
H	d2fk0h2	Coiled coil proteins	Stalk segment of viral fusion proteins	Influenza hemagglutinin (stalk)	Influenza hemagglutinin (stalk)	Influenza hemagglutinin (stalk)	(Influenza A virus (A/Viet Nam/1203/2004(H5N1)) ) [TaxId: 284218 ],	SCOPe (2.08)
H	d2fk0h3	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Influenza A virus (A/Viet Nam/1203/2004(H5N1)) ) [TaxId: 284218 ],	SCOPe (2.08)
L	d2fk0l2	Coiled coil proteins	Stalk segment of viral fusion proteins	Influenza hemagglutinin (stalk)	Influenza hemagglutinin (stalk)	Influenza hemagglutinin (stalk)	(Influenza A virus (A/Viet Nam/1203/2004(H5N1)) ) [TaxId: 284218 ],	SCOPe (2.08)
L	d2fk0l3	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Influenza A virus (A/Viet Nam/1203/2004(H5N1)) ) [TaxId: 284218 ],	SCOPe (2.08)
N	d2fk0n2	Coiled coil proteins	Stalk segment of viral fusion proteins	Influenza hemagglutinin (stalk)	Influenza hemagglutinin (stalk)	Influenza hemagglutinin (stalk)	(Influenza A virus (A/Viet Nam/1203/2004(H5N1)) ) [TaxId: 284218 ],	SCOPe (2.08)
N	d2fk0n3	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Influenza A virus (A/Viet Nam/1203/2004(H5N1)) ) [TaxId: 284218 ],	SCOPe (2.08)
P	d2fk0p2	Coiled coil proteins	Stalk segment of viral fusion proteins	Influenza hemagglutinin (stalk)	Influenza hemagglutinin (stalk)	Influenza hemagglutinin (stalk)	(Influenza A virus (A/Viet Nam/1203/2004(H5N1)) ) [TaxId: 284218 ],	SCOPe (2.08)
P	d2fk0p3	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Influenza A virus (A/Viet Nam/1203/2004(H5N1)) ) [TaxId: 284218 ],	SCOPe (2.08)
R	d2fk0r2	Coiled coil proteins	Stalk segment of viral fusion proteins	Influenza hemagglutinin (stalk)	Influenza hemagglutinin (stalk)	Influenza hemagglutinin (stalk)	(Influenza A virus (A/Viet Nam/1203/2004(H5N1)) ) [TaxId: 284218 ],	SCOPe (2.08)
R	d2fk0r3	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Influenza A virus (A/Viet Nam/1203/2004(H5N1)) ) [TaxId: 284218 ],	SCOPe (2.08)
J	d2fk0j2	Coiled coil proteins	Stalk segment of viral fusion proteins	Influenza hemagglutinin (stalk)	Influenza hemagglutinin (stalk)	Influenza hemagglutinin (stalk)	(Influenza A virus (A/Viet Nam/1203/2004(H5N1)) ) [TaxId: 284218 ],	SCOPe (2.08)
J	d2fk0j3	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Influenza A virus (A/Viet Nam/1203/2004(H5N1)) ) [TaxId: 284218 ],	SCOPe (2.08)
A	d2fk0a1	All beta proteins	Viral protein domain	Viral protein domain	Influenza hemagglutinin headpiece	Hemagglutinin	(Influenza A virus (A/Viet Nam/1203/2004(H5N1)) ) [TaxId: 284218 ],	SCOPe (2.08)
A	d2fk0a2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Influenza A virus (A/Viet Nam/1203/2004(H5N1)) ) [TaxId: 284218 ],	SCOPe (2.08)
C	d2fk0c2	All beta proteins	Viral protein domain	Viral protein domain	Influenza hemagglutinin headpiece	automated matches	(Influenza A virus (A/Viet Nam/1203/2004(H5N1)) ) [TaxId: 284218 ],	SCOPe (2.08)
C	d2fk0c3	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Influenza A virus (A/Viet Nam/1203/2004(H5N1)) ) [TaxId: 284218 ],	SCOPe (2.08)
E	d2fk0e2	All beta proteins	Viral protein domain	Viral protein domain	Influenza hemagglutinin headpiece	automated matches	(Influenza A virus (A/Viet Nam/1203/2004(H5N1)) ) [TaxId: 284218 ],	SCOPe (2.08)
E	d2fk0e3	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Influenza A virus (A/Viet Nam/1203/2004(H5N1)) ) [TaxId: 284218 ],	SCOPe (2.08)
G	d2fk0g2	All beta proteins	Viral protein domain	Viral protein domain	Influenza hemagglutinin headpiece	automated matches	(Influenza A virus (A/Viet Nam/1203/2004(H5N1)) ) [TaxId: 284218 ],	SCOPe (2.08)
G	d2fk0g3	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Influenza A virus (A/Viet Nam/1203/2004(H5N1)) ) [TaxId: 284218 ],	SCOPe (2.08)
I	d2fk0i2	All beta proteins	Viral protein domain	Viral protein domain	Influenza hemagglutinin headpiece	automated matches	(Influenza A virus (A/Viet Nam/1203/2004(H5N1)) ) [TaxId: 284218 ],	SCOPe (2.08)
I	d2fk0i3	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Influenza A virus (A/Viet Nam/1203/2004(H5N1)) ) [TaxId: 284218 ],	SCOPe (2.08)
K	d2fk0k2	All beta proteins	Viral protein domain	Viral protein domain	Influenza hemagglutinin headpiece	automated matches	(Influenza A virus (A/Viet Nam/1203/2004(H5N1)) ) [TaxId: 284218 ],	SCOPe (2.08)
K	d2fk0k3	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Influenza A virus (A/Viet Nam/1203/2004(H5N1)) ) [TaxId: 284218 ],	SCOPe (2.08)
M	d2fk0m2	All beta proteins	Viral protein domain	Viral protein domain	Influenza hemagglutinin headpiece	automated matches	(Influenza A virus (A/Viet Nam/1203/2004(H5N1)) ) [TaxId: 284218 ],	SCOPe (2.08)
M	d2fk0m3	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Influenza A virus (A/Viet Nam/1203/2004(H5N1)) ) [TaxId: 284218 ],	SCOPe (2.08)
O	d2fk0o2	All beta proteins	Viral protein domain	Viral protein domain	Influenza hemagglutinin headpiece	automated matches	(Influenza A virus (A/Viet Nam/1203/2004(H5N1)) ) [TaxId: 284218 ],	SCOPe (2.08)
O	d2fk0o3	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Influenza A virus (A/Viet Nam/1203/2004(H5N1)) ) [TaxId: 284218 ],	SCOPe (2.08)
Q	d2fk0q2	All beta proteins	Viral protein domain	Viral protein domain	Influenza hemagglutinin headpiece	automated matches	(Influenza A virus (A/Viet Nam/1203/2004(H5N1)) ) [TaxId: 284218 ],	SCOPe (2.08)
Q	d2fk0q3	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Influenza A virus (A/Viet Nam/1203/2004(H5N1)) ) [TaxId: 284218 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Influenza hemagglutinin (stalk)	8099216	3001616	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Influenza hemagglutinin (stalk)	8099216	3001616	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Influenza hemagglutinin (stalk)	8099216	3001616	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Influenza hemagglutinin (stalk)	8099216	3001616	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	Influenza hemagglutinin (stalk)	8099216	3001616	SCOP2B (2022-06-29)
N	SCOP2B Superfamily	Influenza hemagglutinin (stalk)	8099216	3001616	SCOP2B (2022-06-29)
P	SCOP2B Superfamily	Influenza hemagglutinin (stalk)	8099216	3001616	SCOP2B (2022-06-29)
R	SCOP2 Family	Influenza hemagglutinin (stalk)	8099215	4003840	SCOP2 (2022-06-29)
R	SCOP2 Superfamily	Influenza hemagglutinin (stalk)	8099216	3001616	SCOP2 (2022-06-29)
J	SCOP2B Superfamily	Influenza hemagglutinin (stalk)	8099216	3001616	SCOP2B (2022-06-29)
A	SCOP2 Family	Influenza hemagglutinin headpiece	8087757	4002506	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Influenza hemagglutinin domain-like	8087758	3001342	SCOP2 (2022-06-29)
C	SCOP2B Superfamily	Influenza hemagglutinin domain-like	8087758	3001342	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Influenza hemagglutinin domain-like	8087758	3001342	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Influenza hemagglutinin domain-like	8087758	3001342	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	Influenza hemagglutinin domain-like	8087758	3001342	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	Influenza hemagglutinin domain-like	8087758	3001342	SCOP2B (2022-06-29)
M	SCOP2B Superfamily	Influenza hemagglutinin domain-like	8087758	3001342	SCOP2B (2022-06-29)
O	SCOP2B Superfamily	Influenza hemagglutinin domain-like	8087758	3001342	SCOP2B (2022-06-29)
Q	SCOP2B Superfamily	Influenza hemagglutinin domain-like	8087758	3001342	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Hemagglutinin_1st	e2fk0A1	A: beta sandwiches	X: jelly-roll	H: Viral protein domain (From Topology)	T: Viral protein domain	F: Hemagglutinin_1st	ECOD (1.6)
C	Hemagglutinin_1st	e2fk0C1	A: beta sandwiches	X: jelly-roll	H: Viral protein domain (From Topology)	T: Viral protein domain	F: Hemagglutinin_1st	ECOD (1.6)
E	Hemagglutinin_1st	e2fk0E1	A: beta sandwiches	X: jelly-roll	H: Viral protein domain (From Topology)	T: Viral protein domain	F: Hemagglutinin_1st	ECOD (1.6)
G	Hemagglutinin_1st	e2fk0G1	A: beta sandwiches	X: jelly-roll	H: Viral protein domain (From Topology)	T: Viral protein domain	F: Hemagglutinin_1st	ECOD (1.6)
I	Hemagglutinin_1st	e2fk0I1	A: beta sandwiches	X: jelly-roll	H: Viral protein domain (From Topology)	T: Viral protein domain	F: Hemagglutinin_1st	ECOD (1.6)
K	Hemagglutinin_1st	e2fk0K1	A: beta sandwiches	X: jelly-roll	H: Viral protein domain (From Topology)	T: Viral protein domain	F: Hemagglutinin_1st	ECOD (1.6)
M	Hemagglutinin_1st	e2fk0M1	A: beta sandwiches	X: jelly-roll	H: Viral protein domain (From Topology)	T: Viral protein domain	F: Hemagglutinin_1st	ECOD (1.6)
O	Hemagglutinin_1st	e2fk0O1	A: beta sandwiches	X: jelly-roll	H: Viral protein domain (From Topology)	T: Viral protein domain	F: Hemagglutinin_1st	ECOD (1.6)
Q	Hemagglutinin_1st	e2fk0Q1	A: beta sandwiches	X: jelly-roll	H: Viral protein domain (From Topology)	T: Viral protein domain	F: Hemagglutinin_1st	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.90.20.10	Alpha Beta	Alpha-Beta Complex	Hemagglutinin Ectodomain	Chain B	CATH (4.3.0)
D	3.90.20.10	Alpha Beta	Alpha-Beta Complex	Hemagglutinin Ectodomain	Chain B	CATH (4.3.0)
F	3.90.20.10	Alpha Beta	Alpha-Beta Complex	Hemagglutinin Ectodomain	Chain B	CATH (4.3.0)
H	3.90.20.10	Alpha Beta	Alpha-Beta Complex	Hemagglutinin Ectodomain	Chain B	CATH (4.3.0)
L	3.90.20.10	Alpha Beta	Alpha-Beta Complex	Hemagglutinin Ectodomain	Chain B	CATH (4.3.0)
N	3.90.20.10	Alpha Beta	Alpha-Beta Complex	Hemagglutinin Ectodomain	Chain B	CATH (4.3.0)
P	3.90.20.10	Alpha Beta	Alpha-Beta Complex	Hemagglutinin Ectodomain	Chain B	CATH (4.3.0)
R	3.90.20.10	Alpha Beta	Alpha-Beta Complex	Hemagglutinin Ectodomain	Chain B	CATH (4.3.0)
J	3.90.20.10	Alpha Beta	Alpha-Beta Complex	Hemagglutinin Ectodomain	Chain B	CATH (4.3.0)
A	2.10.77.10	Mainly Beta	Ribbon	Hemagglutinin	Chain A, domain 2	CATH (4.3.0)
A	3.90.209.20	Alpha Beta	Alpha-Beta Complex	Hemagglutinin (Ha1 Chain)	Chain: A	CATH (4.3.0)
C	2.10.77.10	Mainly Beta	Ribbon	Hemagglutinin	Chain A, domain 2	CATH (4.3.0)
C	3.90.209.20	Alpha Beta	Alpha-Beta Complex	Hemagglutinin (Ha1 Chain)	Chain: A	CATH (4.3.0)
E	2.10.77.10	Mainly Beta	Ribbon	Hemagglutinin	Chain A, domain 2	CATH (4.3.0)
E	3.90.209.20	Alpha Beta	Alpha-Beta Complex	Hemagglutinin (Ha1 Chain)	Chain: A	CATH (4.3.0)
G	2.10.77.10	Mainly Beta	Ribbon	Hemagglutinin	Chain A, domain 2	CATH (4.3.0)
G	3.90.209.20	Alpha Beta	Alpha-Beta Complex	Hemagglutinin (Ha1 Chain)	Chain: A	CATH (4.3.0)
I	2.10.77.10	Mainly Beta	Ribbon	Hemagglutinin	Chain A, domain 2	CATH (4.3.0)
I	3.90.209.20	Alpha Beta	Alpha-Beta Complex	Hemagglutinin (Ha1 Chain)	Chain: A	CATH (4.3.0)
K	2.10.77.10	Mainly Beta	Ribbon	Hemagglutinin	Chain A, domain 2	CATH (4.3.0)
K	3.90.209.20	Alpha Beta	Alpha-Beta Complex	Hemagglutinin (Ha1 Chain)	Chain: A	CATH (4.3.0)
M	2.10.77.10	Mainly Beta	Ribbon	Hemagglutinin	Chain A, domain 2	CATH (4.3.0)
M	3.90.209.20	Alpha Beta	Alpha-Beta Complex	Hemagglutinin (Ha1 Chain)	Chain: A	CATH (4.3.0)
O	2.10.77.10	Mainly Beta	Ribbon	Hemagglutinin	Chain A, domain 2	CATH (4.3.0)
O	3.90.209.20	Alpha Beta	Alpha-Beta Complex	Hemagglutinin (Ha1 Chain)	Chain: A	CATH (4.3.0)
Q	2.10.77.10	Mainly Beta	Ribbon	Hemagglutinin	Chain A, domain 2	CATH (4.3.0)
Q	3.90.209.20	Alpha Beta	Alpha-Beta Complex	Hemagglutinin (Ha1 Chain)	Chain: A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B, D, F, H, J B, D, F, H, J, L, N, P, R	PF00509	Haemagglutinin (Hemagglutinin)	Haemagglutinin	-	Family
A, C, E, G, I A, C, E, G, I, K, M, O, Q	PF00509	Haemagglutinin (Hemagglutinin)	Haemagglutinin	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B, D, F, H, J B, D, F, H, J, L, N, P, R	hemagglutinin	host cell surface binding binding host cell surface receptor binding	viral process fusion of virus membrane with host endosome membrane membrane fusion involved in viral entry into host cell import into cell receptor-mediated endocytosis of virus by host cell biological process involved in interspecies interaction between organisms transport viral life cycle establishment of localization vesicle-mediated transport biological process involved in interaction with host biological process involved in symbiotic interaction localization symbiont entry into host cell viral process fusion of virus membrane with host endosome membrane membrane fusion involved in viral entry into host cell import into cell receptor-mediated endocytosis of virus by host cell biological process involved in interspecies interaction between organisms transport viral life cycle establishment of localization vesicle-mediated transport biological process involved in interaction with host biological process involved in symbiotic interaction localization symbiont entry into host cell clathrin-dependent endocytosis symbiont entry into host cellular process clathrin-dependent endocytosis of virus by host cell receptor-mediated endocytosis endocytosis endocytosis involved in viral entry into host cell transport of virus membrane organization cellular component organization membrane fusion fusion of virus membrane with host plasma membrane cellular component organization or biogenesis virion attachment to host cell adhesion of symbiont to host cell adhesion of symbiont to host	virion component viral membrane viral envelope host cell plasma membrane host cellular component cellular anatomical structure host cell part host cell membrane cell periphery apical part of cell membrane plasma membrane plasma membrane region apical plasma membrane
A, C, E, G, I A, C, E, G, I, K, M, O, Q	hemagglutinin	host cell surface binding binding host cell surface receptor binding	viral process fusion of virus membrane with host endosome membrane membrane fusion involved in viral entry into host cell import into cell receptor-mediated endocytosis of virus by host cell biological process involved in interspecies interaction between organisms transport viral life cycle establishment of localization vesicle-mediated transport biological process involved in interaction with host biological process involved in symbiotic interaction localization symbiont entry into host cell viral process fusion of virus membrane with host endosome membrane membrane fusion involved in viral entry into host cell import into cell receptor-mediated endocytosis of virus by host cell biological process involved in interspecies interaction between organisms transport viral life cycle establishment of localization vesicle-mediated transport biological process involved in interaction with host biological process involved in symbiotic interaction localization symbiont entry into host cell clathrin-dependent endocytosis symbiont entry into host cellular process clathrin-dependent endocytosis of virus by host cell receptor-mediated endocytosis endocytosis endocytosis involved in viral entry into host cell transport of virus membrane organization cellular component organization membrane fusion fusion of virus membrane with host plasma membrane cellular component organization or biogenesis virion attachment to host cell adhesion of symbiont to host cell adhesion of symbiont to host	virion component viral membrane viral envelope host cell plasma membrane host cellular component cellular anatomical structure host cell part host cell membrane cell periphery apical part of cell membrane plasma membrane plasma membrane region apical plasma membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B, D, F, H, J B, D, F, H, J, L, N, P, R	IPR001364	Haemagglutinin, influenzavirus A/B	Family
B, D, F, H, J B, D, F, H, J, L, N, P, R	IPR008980	Viral capsid/haemagglutinin protein	Homologous Superfamily
B, D, F, H, J B, D, F, H, J, L, N, P, R	IPR000149	Haemagglutinin, influenzavirus A	Family
B, D, F, H, J B, D, F, H, J, L, N, P, R	IPR013828	Haemagglutinin, HA1 chain, alpha/beta domain superfamily	Homologous Superfamily
A, C, E, G, I A, C, E, G, I, K, M, O, Q	IPR001364	Haemagglutinin, influenzavirus A/B	Family
A, C, E, G, I A, C, E, G, I, K, M, O, Q	IPR008980	Viral capsid/haemagglutinin protein	Homologous Superfamily
A, C, E, G, I A, C, E, G, I, K, M, O, Q	IPR000149	Haemagglutinin, influenzavirus A	Family
A, C, E, G, I A, C, E, G, I, K, M, O, Q	IPR013828	Haemagglutinin, HA1 chain, alpha/beta domain superfamily	Homologous Superfamily