2G4N

Anomalous substructure of alpha-lactalbumin

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2g4na_	Alpha and beta proteins (a+b)	Lysozyme-like	Lysozyme-like	C-type lysozyme	automated matches	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
B	d2g4nb_	Alpha and beta proteins (a+b)	Lysozyme-like	Lysozyme-like	C-type lysozyme	automated matches	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
C	d2g4nc_	Alpha and beta proteins (a+b)	Lysozyme-like	Lysozyme-like	C-type lysozyme	automated matches	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
D	d2g4nd_	Alpha and beta proteins (a+b)	Lysozyme-like	Lysozyme-like	C-type lysozyme	automated matches	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
E	d2g4ne_	Alpha and beta proteins (a+b)	Lysozyme-like	Lysozyme-like	C-type lysozyme	automated matches	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
F	d2g4nf_	Alpha and beta proteins (a+b)	Lysozyme-like	Lysozyme-like	C-type lysozyme	automated matches	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Lysozyme-like	8033838	3001879	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Lysozyme-like	8033838	3001879	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Lysozyme-like	8033838	3001879	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Lysozyme-like	8033838	3001879	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Lysozyme-like	8033838	3001879	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Lysozyme-like	8033838	3001879	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Lys	e2g4nA1	A: a+b complex topology	X: Lysozyme-like (From Homology)	H: Lysozyme-like	T: Lysozyme-like	F: Lys	ECOD (1.6)
B	Lys	e2g4nB1	A: a+b complex topology	X: Lysozyme-like (From Homology)	H: Lysozyme-like	T: Lysozyme-like	F: Lys	ECOD (1.6)
C	Lys	e2g4nC1	A: a+b complex topology	X: Lysozyme-like (From Homology)	H: Lysozyme-like	T: Lysozyme-like	F: Lys	ECOD (1.6)
D	Lys	e2g4nD1	A: a+b complex topology	X: Lysozyme-like (From Homology)	H: Lysozyme-like	T: Lysozyme-like	F: Lys	ECOD (1.6)
E	Lys	e2g4nE1	A: a+b complex topology	X: Lysozyme-like (From Homology)	H: Lysozyme-like	T: Lysozyme-like	F: Lys	ECOD (1.6)
F	Lys	e2g4nF1	A: a+b complex topology	X: Lysozyme-like (From Homology)	H: Lysozyme-like	T: Lysozyme-like	F: Lys	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.530.10	Mainly Alpha	Orthogonal Bundle	Lysozyme		CATH (4.3.0)
B	1.10.530.10	Mainly Alpha	Orthogonal Bundle	Lysozyme		CATH (4.3.0)
C	1.10.530.10	Mainly Alpha	Orthogonal Bundle	Lysozyme		CATH (4.3.0)
D	1.10.530.10	Mainly Alpha	Orthogonal Bundle	Lysozyme		CATH (4.3.0)
E	1.10.530.10	Mainly Alpha	Orthogonal Bundle	Lysozyme		CATH (4.3.0)
F	1.10.530.10	Mainly Alpha	Orthogonal Bundle	Lysozyme		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF00062	C-type lysozyme/alpha-lactalbumin family (Lys)	C-type lysozyme/alpha-lactalbumin family	Alpha-lactalbumin is the regulatory subunit of lactose synthase, changing the substrate specificity of galactosyltransferase from N-acetylglucosamine to glucose. C-type lysozymes are secreted bacteriolytic enzymes that cleave the peptidoglycan of bac ...	Alpha-lactalbumin is the regulatory subunit of lactose synthase, changing the substrate specificity of galactosyltransferase from N-acetylglucosamine to glucose. C-type lysozymes are secreted bacteriolytic enzymes that cleave the peptidoglycan of bacterial cell walls. Structure is a multi-domain, mixed alpha and beta fold, containing four conserved disulfide bonds.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	Alpha-lactalbumin	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding hydrolase activity, acting on glycosyl bonds peptidoglycan muralytic activity hydrolase activity, hydrolyzing O-glycosyl compounds lysozyme activity hydrolase activity catalytic activity lactose synthase activity UDP-glycosyltransferase activity cation binding ion binding binding calcium ion binding metal ion binding small molecule binding hydrolase activity, acting on glycosyl bonds peptidoglycan muralytic activity hydrolase activity, hydrolyzing O-glycosyl compounds lysozyme activity hydrolase activity catalytic activity lactose synthase activity UDP-glycosyltransferase activity glycosyltransferase activity transferase activity galactosyltransferase activity hexosyltransferase activity UDP-galactosyltransferase activity identical protein binding protein binding	response to ketone response to stimulus response to lipid response to alcohol response to chemical response to oxygen-containing compound response to dehydroepiandrosterone response to organic cyclic compound response to hormone response to steroid hormone response to endogenous stimulus response to progesterone carbohydrate metabolic process carbohydrate biosynthetic process response to ketone response to stimulus response to lipid response to alcohol response to chemical response to oxygen-containing compound response to dehydroepiandrosterone response to organic cyclic compound response to hormone response to steroid hormone response to endogenous stimulus response to progesterone carbohydrate metabolic process carbohydrate biosynthetic process oligosaccharide metabolic process primary metabolic process disaccharide metabolic process lactose metabolic process disaccharide biosynthetic process biosynthetic process oligosaccharide biosynthetic process metabolic process lactose biosynthetic process response to 11-deoxycorticosterone response to mineralocorticoid response to corticosteroid response to estradiol	extracellular region extracellular space cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR001916	Glycoside hydrolase, family 22	Family
A, B, C, D, E A, B, C, D, E, F	IPR000545	Lactalbumin	Family
A, B, C, D, E A, B, C, D, E, F	IPR023346	Lysozyme-like domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR019799	Glycoside hydrolase family 22 domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.