2GA9
Crystal Structure of the Heterodimeric Vaccinia Virus Polyadenylate Polymerase with Bound ATP-gamma-S
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Chains | Domain Info | Class | Fold | Superfamily | Family | Domain | Species | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | d2ga9a_ | Alpha and beta proteins (a/b) | S-adenosyl-L-methionine-dependent methyltransferases | S-adenosyl-L-methionine-dependent methyltransferases | mRNA cap methylase | automated matches | (Vaccinia virus ) [TaxId: 10245 ], | SCOPe (2.08) |
B [auth D] | d2ga9d1 | Multi-domain proteins (alpha and beta) | Poly(A) polymerase catalytic subunit-like | Poly(A) polymerase catalytic subunit-like | Poxvirus poly(A) polymerase catalytic subunit-like | Poly(A) polymerase catalytic subunit, PAPL | (Vaccinia virus ) [TaxId: 10245 ], | SCOPe (2.08) |
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
A | SCOP2B Superfamily | S-adenosyl-L-methionine-dependent methyltransferases | 8032283 | 3000118 | SCOP2B (2022-06-29) |
B [auth D] | SCOP2B Superfamily | Poxvirus poly(A) polymerase N-terminal domain-like | 8055708 | 3002298 | SCOP2B (2022-06-29) |
B [auth D] | SCOP2B Superfamily | Nucleotidyltransferase-like | 8055710 | 3000129 | SCOP2B (2022-06-29) |
B [auth D] | SCOP2B Superfamily | Poly(A) polymerase C-terminal domain-like | 8032899 | 3001629 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | PARP_regulatory | e2ga9A1 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: S-adenosyl-L-methionine-dependent methyltransferases | F: PARP_regulatory | ECOD (1.6) |
B [auth D] | Pox_polyA_pol_N | e2ga9D1 | A: alpha arrays | X: N-terminal helical domain in Poxvirus poly(A) polymerase catalytic subunit (From Topology) | H: N-terminal helical domain in Poxvirus poly(A) polymerase catalytic subunit (From Topology) | T: N-terminal helical domain in Poxvirus poly(A) polymerase catalytic subunit | F: Pox_polyA_pol_N | ECOD (1.6) |
B [auth D] | Pox_polyA_pol_C,Pox_polyA_pol | e2ga9D2 | A: a+b three layers | X: Nucleotidyltransferase-like | H: Nucleotidyltransferase (From Topology) | T: Nucleotidyltransferase | F: Pox_polyA_pol_C,Pox_polyA_pol | ECOD (1.6) |
B [auth D] | Pox_polyA_pol_C | e2ga9D3 | A: a+b complex topology | X: C-terminal a+b domain in Poly(A) polymerase catalytic subunit (From Topology) | H: C-terminal a+b domain in Poly(A) polymerase catalytic subunit (From Topology) | T: C-terminal a+b domain in Poly(A) polymerase catalytic subunit | F: Pox_polyA_pol_C | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A | 3.40.50.150 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | Vaccinia Virus protein VP39 | CATH (4.3.0) |
B [auth D] | 1.20.1270.320 | Mainly Alpha | Up-down Bundle | Substrate Binding Domain Of Dnak | Chain:A | CATH (4.3.0) |
B [auth D] | 3.30.460.60 | Alpha Beta | 2-Layer Sandwich | Beta Polymerase | domain 2 | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF01358 | Poly A polymerase regulatory subunit (PARP_regulatory) | Poly A polymerase regulatory subunit | - | Domain | |
B [auth D] | PF03296 | Poxvirus poly(A) polymerase nucleotidyltransferase domain (Pox_polyA_pol) | Poxvirus poly(A) polymerase nucleotidyltransferase domain | - | Domain |
B [auth D] | PF12629 | Poxvirus poly(A) polymerase C-terminal domain (Pox_polyA_pol_C) | Poxvirus poly(A) polymerase C-terminal domain | This domain is found at the C-terminus of the pox virus PolyA polymerase protein [1]. | Domain |