Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2 FamilyLigand-gated protein channel 8029650 4003084 SCOP2 (2022-06-29)
ASCOP2 SuperfamilyPorins 8042029 3000224 SCOP2 (2022-06-29)
BSCOP2B SuperfamilyTolA/TonB C-terminal domain-like 8042743 3000464 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
ATonB_dep_Rece2gskA1 A: beta barrelsX: Outer membrane meander beta-barrelsH: PorinsT: Ligand-gated protein channelF: TonB_dep_RecECOD (1.6)
APluge2gskA2 A: a+b complex topologyX: N0 domain in phage tail proteins and secretins-likeH: TonB-dependent receptor plug domain (From Topology)T: TonB-dependent receptor plug domainF: PlugECOD (1.6)
BTonB_Ce2gskB1 A: a+b two layersX: TolA/TonB C-terminal domainH: TolA/TonB C-terminal domain (From Topology)T: TolA/TonB C-terminal domainF: TonB_CECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A2.170.130.10 Mainly Beta Beta Complex Ferric Hydroxamate Uptake Protein Chain A, domain 1CATH (4.3.0)
A2.40.170.20 Mainly Beta Beta Barrel Maltoporin Chain ACATH (4.3.0)
B3.30.2420.10 Alpha Beta 2-Layer Sandwich TolA/TonB C-terminal domain TonBCATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF00593TonB dependent receptor-like, beta-barrel (TonB_dep_Rec_b-barrel)TonB dependent receptor-like, beta-barrelThis entry represents the beta-barrel domain of TonB-dependent receptors, such as BtuB, CirA, FatA, FcuT, FecA, FepA, among others [1].Domain
PF07715TonB-dependent Receptor Plug Domain (Plug)TonB-dependent Receptor Plug DomainThe Plug domain has been shown to be an independently folding subunit of the TonB-dependent receptors ([1]). It acts as the channel gate, blocking the pore until the channel is bound by ligand. At this point it under goes conformational changes opens ...The Plug domain has been shown to be an independently folding subunit of the TonB-dependent receptors ([1]). It acts as the channel gate, blocking the pore until the channel is bound by ligand. At this point it under goes conformational changes opens the channel.
Domain
PF03544Gram-negative bacterial TonB protein C-terminal (TonB_C)Gram-negative bacterial TonB protein C-terminalThe TonB_C domain is the well-characterised C-terminal region of the TonB receptor molecule. This protein is bound to an inner membrane-bound protein ExbB via a globular domain and has a flexible middle region that is likely to help in positioning th ...The TonB_C domain is the well-characterised C-terminal region of the TonB receptor molecule. This protein is bound to an inner membrane-bound protein ExbB via a globular domain and has a flexible middle region that is likely to help in positioning the C-terminal domain into the iron-transporter barrel in the outer membrane [1]. TonB_C interacts with the N-terminal TonB box of the outer membrane transporter that binds the Fe3+-siderophore complex. The barrel of the transporter, consisting of 22 beta-sheets and an inside plug, binds the iron complex in the barrel entrance [2].
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
Vitamin B12 transporter btuB
protein TONB

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage