Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad2hg4a6 Alpha and beta proteins (a/b) FabD/lysophospholipase-like FabD/lysophospholipase-like FabD-like Catalytic domain from acyl transferase (AT) domain of 6-deoxyerythronolide B synthase (DEBS) (Saccharopolyspora erythraea ) [TaxId: 1836 ], SCOPe (2.08)
Ad2hg4a2 Alpha and beta proteins (a/b) Thiolase-like Thiolase-like Thiolase-related Ketosynthase domain from 6-deoxyerythronolide B synthase (DEBS), C-terminal domain (Saccharopolyspora erythraea ) [TaxId: 1836 ], SCOPe (2.08)
Ad2hg4a3 Alpha and beta proteins (a/b) Thiolase-like Thiolase-like Thiolase-related Ketosynthase domain from 6-deoxyerythronolide B synthase (DEBS), N-terminal domain (Saccharopolyspora erythraea ) [TaxId: 1836 ], SCOPe (2.08)
Ad2hg4a5 Alpha and beta proteins (a+b) Ferredoxin-like Probable ACP-binding domain of malonyl-CoA ACP transacylase Probable ACP-binding domain of malonyl-CoA ACP transacylase Ferredoxin-like domain from acyl transferase (AT) domain of 6-deoxyerythronolide B synthase (DEBS) (Saccharopolyspora erythraea ) [TaxId: 1836 ], SCOPe (2.08)
Ad2hg4a4 Alpha and beta proteins (a+b) KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS)-like KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS)-like KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS)-like KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS) (Saccharopolyspora erythraea ) [TaxId: 1836 ], SCOPe (2.08)
Ad2hg4a1 Coiled coil proteins Parallel coiled-coil N-terminal linker of 6-deoxyerythronolide B synthase (DEBS) N-terminal linker of 6-deoxyerythronolide B synthase (DEBS) N-terminal linker of 6-deoxyerythronolide B synthase (DEBS) (Saccharopolyspora erythraea ) [TaxId: 1836 ], SCOPe (2.08)
Ad2hg4a7 Peptides C-terminal linker of 6-deoxyerythronolide B synthase (DEBS)-like C-terminal linker of 6-deoxyerythronolide B synthase (DEBS)-like C-terminal linker of 6-deoxyerythronolide B synthase (DEBS)-like C-terminal linker of 6-deoxyerythronolide B synthase (DEBS) (Saccharopolyspora erythraea ) [TaxId: 1836 ], SCOPe (2.08)
Bd2hg4b6 Alpha and beta proteins (a/b) FabD/lysophospholipase-like FabD/lysophospholipase-like FabD-like Catalytic domain from acyl transferase (AT) domain of 6-deoxyerythronolide B synthase (DEBS) (Saccharopolyspora erythraea ) [TaxId: 1836 ], SCOPe (2.08)
Bd2hg4b2 Alpha and beta proteins (a/b) Thiolase-like Thiolase-like Thiolase-related Ketosynthase domain from 6-deoxyerythronolide B synthase (DEBS), C-terminal domain (Saccharopolyspora erythraea ) [TaxId: 1836 ], SCOPe (2.08)
Bd2hg4b3 Alpha and beta proteins (a/b) Thiolase-like Thiolase-like Thiolase-related Ketosynthase domain from 6-deoxyerythronolide B synthase (DEBS), N-terminal domain (Saccharopolyspora erythraea ) [TaxId: 1836 ], SCOPe (2.08)
Bd2hg4b5 Alpha and beta proteins (a+b) Ferredoxin-like Probable ACP-binding domain of malonyl-CoA ACP transacylase Probable ACP-binding domain of malonyl-CoA ACP transacylase Ferredoxin-like domain from acyl transferase (AT) domain of 6-deoxyerythronolide B synthase (DEBS) (Saccharopolyspora erythraea ) [TaxId: 1836 ], SCOPe (2.08)
Bd2hg4b4 Alpha and beta proteins (a+b) KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS)-like KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS)-like KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS)-like KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS) (Saccharopolyspora erythraea ) [TaxId: 1836 ], SCOPe (2.08)
Bd2hg4b1 Coiled coil proteins Parallel coiled-coil N-terminal linker of 6-deoxyerythronolide B synthase (DEBS) N-terminal linker of 6-deoxyerythronolide B synthase (DEBS) N-terminal linker of 6-deoxyerythronolide B synthase (DEBS) (Saccharopolyspora erythraea ) [TaxId: 1836 ], SCOPe (2.08)
Bd2hg4b7 Peptides C-terminal linker of 6-deoxyerythronolide B synthase (DEBS)-like C-terminal linker of 6-deoxyerythronolide B synthase (DEBS)-like C-terminal linker of 6-deoxyerythronolide B synthase (DEBS)-like C-terminal linker of 6-deoxyerythronolide B synthase (DEBS) (Saccharopolyspora erythraea ) [TaxId: 1836 ], SCOPe (2.08)
Cd2hg4c6 Alpha and beta proteins (a/b) FabD/lysophospholipase-like FabD/lysophospholipase-like FabD-like Catalytic domain from acyl transferase (AT) domain of 6-deoxyerythronolide B synthase (DEBS) (Saccharopolyspora erythraea ) [TaxId: 1836 ], SCOPe (2.08)
Cd2hg4c2 Alpha and beta proteins (a/b) Thiolase-like Thiolase-like Thiolase-related Ketosynthase domain from 6-deoxyerythronolide B synthase (DEBS), C-terminal domain (Saccharopolyspora erythraea ) [TaxId: 1836 ], SCOPe (2.08)
Cd2hg4c3 Alpha and beta proteins (a/b) Thiolase-like Thiolase-like Thiolase-related Ketosynthase domain from 6-deoxyerythronolide B synthase (DEBS), N-terminal domain (Saccharopolyspora erythraea ) [TaxId: 1836 ], SCOPe (2.08)
Cd2hg4c5 Alpha and beta proteins (a+b) Ferredoxin-like Probable ACP-binding domain of malonyl-CoA ACP transacylase Probable ACP-binding domain of malonyl-CoA ACP transacylase Ferredoxin-like domain from acyl transferase (AT) domain of 6-deoxyerythronolide B synthase (DEBS) (Saccharopolyspora erythraea ) [TaxId: 1836 ], SCOPe (2.08)
Cd2hg4c4 Alpha and beta proteins (a+b) KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS)-like KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS)-like KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS)-like KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS) (Saccharopolyspora erythraea ) [TaxId: 1836 ], SCOPe (2.08)
Cd2hg4c1 Coiled coil proteins Parallel coiled-coil N-terminal linker of 6-deoxyerythronolide B synthase (DEBS) N-terminal linker of 6-deoxyerythronolide B synthase (DEBS) N-terminal linker of 6-deoxyerythronolide B synthase (DEBS) (Saccharopolyspora erythraea ) [TaxId: 1836 ], SCOPe (2.08)
Cd2hg4c7 Peptides C-terminal linker of 6-deoxyerythronolide B synthase (DEBS)-like C-terminal linker of 6-deoxyerythronolide B synthase (DEBS)-like C-terminal linker of 6-deoxyerythronolide B synthase (DEBS)-like C-terminal linker of 6-deoxyerythronolide B synthase (DEBS) (Saccharopolyspora erythraea ) [TaxId: 1836 ], SCOPe (2.08)
Dd2hg4d6 Alpha and beta proteins (a/b) FabD/lysophospholipase-like FabD/lysophospholipase-like FabD-like Catalytic domain from acyl transferase (AT) domain of 6-deoxyerythronolide B synthase (DEBS) (Saccharopolyspora erythraea ) [TaxId: 1836 ], SCOPe (2.08)
Dd2hg4d2 Alpha and beta proteins (a/b) Thiolase-like Thiolase-like Thiolase-related Ketosynthase domain from 6-deoxyerythronolide B synthase (DEBS), C-terminal domain (Saccharopolyspora erythraea ) [TaxId: 1836 ], SCOPe (2.08)
Dd2hg4d3 Alpha and beta proteins (a/b) Thiolase-like Thiolase-like Thiolase-related Ketosynthase domain from 6-deoxyerythronolide B synthase (DEBS), N-terminal domain (Saccharopolyspora erythraea ) [TaxId: 1836 ], SCOPe (2.08)
Dd2hg4d5 Alpha and beta proteins (a+b) Ferredoxin-like Probable ACP-binding domain of malonyl-CoA ACP transacylase Probable ACP-binding domain of malonyl-CoA ACP transacylase Ferredoxin-like domain from acyl transferase (AT) domain of 6-deoxyerythronolide B synthase (DEBS) (Saccharopolyspora erythraea ) [TaxId: 1836 ], SCOPe (2.08)
Dd2hg4d4 Alpha and beta proteins (a+b) KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS)-like KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS)-like KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS)-like KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS) (Saccharopolyspora erythraea ) [TaxId: 1836 ], SCOPe (2.08)
Dd2hg4d1 Coiled coil proteins Parallel coiled-coil N-terminal linker of 6-deoxyerythronolide B synthase (DEBS) N-terminal linker of 6-deoxyerythronolide B synthase (DEBS) N-terminal linker of 6-deoxyerythronolide B synthase (DEBS) (Saccharopolyspora erythraea ) [TaxId: 1836 ], SCOPe (2.08)
Dd2hg4d7 Peptides C-terminal linker of 6-deoxyerythronolide B synthase (DEBS)-like C-terminal linker of 6-deoxyerythronolide B synthase (DEBS)-like C-terminal linker of 6-deoxyerythronolide B synthase (DEBS)-like C-terminal linker of 6-deoxyerythronolide B synthase (DEBS) (Saccharopolyspora erythraea ) [TaxId: 1836 ], SCOPe (2.08)
Ed2hg4e6 Alpha and beta proteins (a/b) FabD/lysophospholipase-like FabD/lysophospholipase-like FabD-like Catalytic domain from acyl transferase (AT) domain of 6-deoxyerythronolide B synthase (DEBS) (Saccharopolyspora erythraea ) [TaxId: 1836 ], SCOPe (2.08)
Ed2hg4e2 Alpha and beta proteins (a/b) Thiolase-like Thiolase-like Thiolase-related Ketosynthase domain from 6-deoxyerythronolide B synthase (DEBS), C-terminal domain (Saccharopolyspora erythraea ) [TaxId: 1836 ], SCOPe (2.08)
Ed2hg4e3 Alpha and beta proteins (a/b) Thiolase-like Thiolase-like Thiolase-related Ketosynthase domain from 6-deoxyerythronolide B synthase (DEBS), N-terminal domain (Saccharopolyspora erythraea ) [TaxId: 1836 ], SCOPe (2.08)
Ed2hg4e5 Alpha and beta proteins (a+b) Ferredoxin-like Probable ACP-binding domain of malonyl-CoA ACP transacylase Probable ACP-binding domain of malonyl-CoA ACP transacylase Ferredoxin-like domain from acyl transferase (AT) domain of 6-deoxyerythronolide B synthase (DEBS) (Saccharopolyspora erythraea ) [TaxId: 1836 ], SCOPe (2.08)
Ed2hg4e4 Alpha and beta proteins (a+b) KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS)-like KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS)-like KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS)-like KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS) (Saccharopolyspora erythraea ) [TaxId: 1836 ], SCOPe (2.08)
Ed2hg4e1 Coiled coil proteins Parallel coiled-coil N-terminal linker of 6-deoxyerythronolide B synthase (DEBS) N-terminal linker of 6-deoxyerythronolide B synthase (DEBS) N-terminal linker of 6-deoxyerythronolide B synthase (DEBS) (Saccharopolyspora erythraea ) [TaxId: 1836 ], SCOPe (2.08)
Ed2hg4e7 Peptides C-terminal linker of 6-deoxyerythronolide B synthase (DEBS)-like C-terminal linker of 6-deoxyerythronolide B synthase (DEBS)-like C-terminal linker of 6-deoxyerythronolide B synthase (DEBS)-like C-terminal linker of 6-deoxyerythronolide B synthase (DEBS) (Saccharopolyspora erythraea ) [TaxId: 1836 ], SCOPe (2.08)
Fd2hg4f6 Alpha and beta proteins (a/b) FabD/lysophospholipase-like FabD/lysophospholipase-like FabD-like Catalytic domain from acyl transferase (AT) domain of 6-deoxyerythronolide B synthase (DEBS) (Saccharopolyspora erythraea ) [TaxId: 1836 ], SCOPe (2.08)
Fd2hg4f2 Alpha and beta proteins (a/b) Thiolase-like Thiolase-like Thiolase-related Ketosynthase domain from 6-deoxyerythronolide B synthase (DEBS), C-terminal domain (Saccharopolyspora erythraea ) [TaxId: 1836 ], SCOPe (2.08)
Fd2hg4f3 Alpha and beta proteins (a/b) Thiolase-like Thiolase-like Thiolase-related Ketosynthase domain from 6-deoxyerythronolide B synthase (DEBS), N-terminal domain (Saccharopolyspora erythraea ) [TaxId: 1836 ], SCOPe (2.08)
Fd2hg4f5 Alpha and beta proteins (a+b) Ferredoxin-like Probable ACP-binding domain of malonyl-CoA ACP transacylase Probable ACP-binding domain of malonyl-CoA ACP transacylase Ferredoxin-like domain from acyl transferase (AT) domain of 6-deoxyerythronolide B synthase (DEBS) (Saccharopolyspora erythraea ) [TaxId: 1836 ], SCOPe (2.08)
Fd2hg4f4 Alpha and beta proteins (a+b) KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS)-like KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS)-like KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS)-like KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS) (Saccharopolyspora erythraea ) [TaxId: 1836 ], SCOPe (2.08)
Fd2hg4f1 Coiled coil proteins Parallel coiled-coil N-terminal linker of 6-deoxyerythronolide B synthase (DEBS) N-terminal linker of 6-deoxyerythronolide B synthase (DEBS) N-terminal linker of 6-deoxyerythronolide B synthase (DEBS) (Saccharopolyspora erythraea ) [TaxId: 1836 ], SCOPe (2.08)
Fd2hg4f7 Peptides C-terminal linker of 6-deoxyerythronolide B synthase (DEBS)-like C-terminal linker of 6-deoxyerythronolide B synthase (DEBS)-like C-terminal linker of 6-deoxyerythronolide B synthase (DEBS)-like C-terminal linker of 6-deoxyerythronolide B synthase (DEBS) (Saccharopolyspora erythraea ) [TaxId: 1836 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyKASAT domain-like 8055902 3002319 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyThiolase-like 8055904 3000122 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyFabD/lysophospholipase-like 8055906 3001121 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyKASAT domain-like 8055902 3002319 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyFabD/lysophospholipase-like 8055906 3001121 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyProbable ACP-binding domain of malonyl-CoA ACP transacylase 8055908 3001224 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyPKS docking domain-like 8055901 3002322 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyThiolase-like 8055904 3000122 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyPKS docking domain-like 8055901 3002322 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyKASAT domain-like 8055902 3002319 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyFabD/lysophospholipase-like 8055906 3001121 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyProbable ACP-binding domain of malonyl-CoA ACP transacylase 8055908 3001224 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyKASAT domain-like 8055902 3002319 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyFabD/lysophospholipase-like 8055906 3001121 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyPKS docking domain-like 8055901 3002322 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyThiolase-like 8055904 3000122 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyFabD/lysophospholipase-like 8055906 3001121 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyFabD/lysophospholipase-like 8055906 3001121 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyProbable ACP-binding domain of malonyl-CoA ACP transacylase 8055908 3001224 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyKASAT domain-like 8055902 3002319 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyKASAT domain-like 8055902 3002319 SCOP2B (2022-06-29)
DSCOP2 FamilyKASAT domain-like 8045098 4004293 SCOP2 (2022-06-29)
DSCOP2 FamilyPKS docking region-like 8051502 4007409 SCOP2 (2022-06-29)
DSCOP2 FamilyThiolase-related 8055903 4000245 SCOP2 (2022-06-29)
DSCOP2 FamilyFabD-like 8055905 4003614 SCOP2 (2022-06-29)
DSCOP2 FamilyProbable ACP-binding domain of malonyl-CoA ACP transacylase 8055907 4001289 SCOP2 (2022-06-29)
DSCOP2 SuperfamilyKASAT domain-like 8055902 3002319 SCOP2 (2022-06-29)
DSCOP2 SuperfamilyPKS docking domain-like 8055901 3002322 SCOP2 (2022-06-29)
DSCOP2 SuperfamilyThiolase-like 8055904 3000122 SCOP2 (2022-06-29)
DSCOP2 SuperfamilyFabD/lysophospholipase-like 8055906 3001121 SCOP2 (2022-06-29)
DSCOP2 SuperfamilyProbable ACP-binding domain of malonyl-CoA ACP transacylase 8055908 3001224 SCOP2 (2022-06-29)
ESCOP2B SuperfamilyKASAT domain-like 8055902 3002319 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyThiolase-like 8055904 3000122 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyProbable ACP-binding domain of malonyl-CoA ACP transacylase 8055908 3001224 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyFabD/lysophospholipase-like 8055906 3001121 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyKASAT domain-like 8055902 3002319 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyFabD/lysophospholipase-like 8055906 3001121 SCOP2B (2022-06-29)
FSCOP2B SuperfamilyThiolase-like 8055904 3000122 SCOP2B (2022-06-29)
FSCOP2B SuperfamilyFabD/lysophospholipase-like 8055906 3001121 SCOP2B (2022-06-29)
FSCOP2B SuperfamilyKASAT domain-like 8055902 3002319 SCOP2B (2022-06-29)
FSCOP2B SuperfamilyKASAT domain-like 8055902 3002319 SCOP2B (2022-06-29)
FSCOP2B SuperfamilyFabD/lysophospholipase-like 8055906 3001121 SCOP2B (2022-06-29)
FSCOP2B SuperfamilyProbable ACP-binding domain of malonyl-CoA ACP transacylase 8055908 3001224 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
ADocking_1e2hg4A7 A: alpha duplicates or obligate multimersX: Docking domains in modular polyketide synthasesH: Class 1 N-terminal docking domain (From Topology)T: Class 1 N-terminal docking domainF: Docking_1ECOD (1.6)
AAcyl_transf_1_2nd_1e2hg4A3 A: a+b two layersX: Alpha-beta plaitsH: Probable ACP-binding domain of malonyl-CoA ACP transacylase (From Topology)T: Probable ACP-binding domain of malonyl-CoA ACP transacylaseF: Acyl_transf_1_2nd_1ECOD (1.6)
APksD_2e2hg4A1 A: a+b two layersX: KS-MAT linker domain in fatty acid synthase (From Topology)H: KS-MAT linker domain in fatty acid synthase (From Topology)T: KS-MAT linker domain in fatty acid synthaseF: PksD_2ECOD (1.6)
AAcyl_transf_1_1ste2hg4A8 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Class I glutamine amidotransferase-likeT: FabD/lysophospholipase-likeF: Acyl_transf_1_1stECOD (1.6)
Aketoacyl-synte2hg4A4 A: a/b three-layered sandwichesX: Thiolase-like (From Topology)H: Thiolase-like (From Topology)T: Thiolase-likeF: ketoacyl-syntECOD (1.6)
AKetoacyl-synt_Ce2hg4A6 A: a/b three-layered sandwichesX: Thiolase-like (From Topology)H: Thiolase-like (From Topology)T: Thiolase-likeF: Ketoacyl-synt_CECOD (1.6)
BDocking_1e2hg4B7 A: alpha duplicates or obligate multimersX: Docking domains in modular polyketide synthasesH: Class 1 N-terminal docking domain (From Topology)T: Class 1 N-terminal docking domainF: Docking_1ECOD (1.6)
BAcyl_transf_1_2nd_1e2hg4B3 A: a+b two layersX: Alpha-beta plaitsH: Probable ACP-binding domain of malonyl-CoA ACP transacylase (From Topology)T: Probable ACP-binding domain of malonyl-CoA ACP transacylaseF: Acyl_transf_1_2nd_1ECOD (1.6)
BPksD_2e2hg4B4 A: a+b two layersX: KS-MAT linker domain in fatty acid synthase (From Topology)H: KS-MAT linker domain in fatty acid synthase (From Topology)T: KS-MAT linker domain in fatty acid synthaseF: PksD_2ECOD (1.6)
BAcyl_transf_1_1ste2hg4B8 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Class I glutamine amidotransferase-likeT: FabD/lysophospholipase-likeF: Acyl_transf_1_1stECOD (1.6)
Bketoacyl-synte2hg4B5 A: a/b three-layered sandwichesX: Thiolase-like (From Topology)H: Thiolase-like (From Topology)T: Thiolase-likeF: ketoacyl-syntECOD (1.6)
BKetoacyl-synt_Ce2hg4B6 A: a/b three-layered sandwichesX: Thiolase-like (From Topology)H: Thiolase-like (From Topology)T: Thiolase-likeF: Ketoacyl-synt_CECOD (1.6)
CDocking_1e2hg4C7 A: alpha duplicates or obligate multimersX: Docking domains in modular polyketide synthasesH: Class 1 N-terminal docking domain (From Topology)T: Class 1 N-terminal docking domainF: Docking_1ECOD (1.6)
CAcyl_transf_1_2nd_1e2hg4C2 A: a+b two layersX: Alpha-beta plaitsH: Probable ACP-binding domain of malonyl-CoA ACP transacylase (From Topology)T: Probable ACP-binding domain of malonyl-CoA ACP transacylaseF: Acyl_transf_1_2nd_1ECOD (1.6)
CPksD_2e2hg4C4 A: a+b two layersX: KS-MAT linker domain in fatty acid synthase (From Topology)H: KS-MAT linker domain in fatty acid synthase (From Topology)T: KS-MAT linker domain in fatty acid synthaseF: PksD_2ECOD (1.6)
CAcyl_transf_1_1ste2hg4C8 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Class I glutamine amidotransferase-likeT: FabD/lysophospholipase-likeF: Acyl_transf_1_1stECOD (1.6)
Cketoacyl-synte2hg4C5 A: a/b three-layered sandwichesX: Thiolase-like (From Topology)H: Thiolase-like (From Topology)T: Thiolase-likeF: ketoacyl-syntECOD (1.6)
CKetoacyl-synt_Ce2hg4C6 A: a/b three-layered sandwichesX: Thiolase-like (From Topology)H: Thiolase-like (From Topology)T: Thiolase-likeF: Ketoacyl-synt_CECOD (1.6)
DDocking_1e2hg4D7 A: alpha duplicates or obligate multimersX: Docking domains in modular polyketide synthasesH: Class 1 N-terminal docking domain (From Topology)T: Class 1 N-terminal docking domainF: Docking_1ECOD (1.6)
DAcyl_transf_1_2nd_1e2hg4D4 A: a+b two layersX: Alpha-beta plaitsH: Probable ACP-binding domain of malonyl-CoA ACP transacylase (From Topology)T: Probable ACP-binding domain of malonyl-CoA ACP transacylaseF: Acyl_transf_1_2nd_1ECOD (1.6)
DPksD_2e2hg4D3 A: a+b two layersX: KS-MAT linker domain in fatty acid synthase (From Topology)H: KS-MAT linker domain in fatty acid synthase (From Topology)T: KS-MAT linker domain in fatty acid synthaseF: PksD_2ECOD (1.6)
DAcyl_transf_1_1ste2hg4D8 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Class I glutamine amidotransferase-likeT: FabD/lysophospholipase-likeF: Acyl_transf_1_1stECOD (1.6)
Dketoacyl-synte2hg4D5 A: a/b three-layered sandwichesX: Thiolase-like (From Topology)H: Thiolase-like (From Topology)T: Thiolase-likeF: ketoacyl-syntECOD (1.6)
DKetoacyl-synt_Ce2hg4D6 A: a/b three-layered sandwichesX: Thiolase-like (From Topology)H: Thiolase-like (From Topology)T: Thiolase-likeF: Ketoacyl-synt_CECOD (1.6)
EAcyl_transf_1_2nd_1e2hg4E3 A: a+b two layersX: Alpha-beta plaitsH: Probable ACP-binding domain of malonyl-CoA ACP transacylase (From Topology)T: Probable ACP-binding domain of malonyl-CoA ACP transacylaseF: Acyl_transf_1_2nd_1ECOD (1.6)
EPksD_2e2hg4E4 A: a+b two layersX: KS-MAT linker domain in fatty acid synthase (From Topology)H: KS-MAT linker domain in fatty acid synthase (From Topology)T: KS-MAT linker domain in fatty acid synthaseF: PksD_2ECOD (1.6)
EAcyl_transf_1_1ste2hg4E7 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Class I glutamine amidotransferase-likeT: FabD/lysophospholipase-likeF: Acyl_transf_1_1stECOD (1.6)
Eketoacyl-synte2hg4E5 A: a/b three-layered sandwichesX: Thiolase-like (From Topology)H: Thiolase-like (From Topology)T: Thiolase-likeF: ketoacyl-syntECOD (1.6)
EKetoacyl-synt_Ce2hg4E6 A: a/b three-layered sandwichesX: Thiolase-like (From Topology)H: Thiolase-like (From Topology)T: Thiolase-likeF: Ketoacyl-synt_CECOD (1.6)
FAcyl_transf_1_2nd_1e2hg4F5 A: a+b two layersX: Alpha-beta plaitsH: Probable ACP-binding domain of malonyl-CoA ACP transacylase (From Topology)T: Probable ACP-binding domain of malonyl-CoA ACP transacylaseF: Acyl_transf_1_2nd_1ECOD (1.6)
FPksD_2e2hg4F2 A: a+b two layersX: KS-MAT linker domain in fatty acid synthase (From Topology)H: KS-MAT linker domain in fatty acid synthase (From Topology)T: KS-MAT linker domain in fatty acid synthaseF: PksD_2ECOD (1.6)
FAcyl_transf_1_1ste2hg4F7 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Class I glutamine amidotransferase-likeT: FabD/lysophospholipase-likeF: Acyl_transf_1_1stECOD (1.6)
FKetoacyl-synt_Ce2hg4F6 A: a/b three-layered sandwichesX: Thiolase-like (From Topology)H: Thiolase-like (From Topology)T: Thiolase-likeF: Ketoacyl-synt_CECOD (1.6)
Fketoacyl-synt,Docking_1e2hg4F4 A: a/b three-layered sandwichesX: Thiolase-like (From Topology)H: Thiolase-like (From Topology)T: Thiolase-likeF: ketoacyl-synt,Docking_1ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.40.47.10 Alpha Beta 3-Layer(aba) Sandwich Peroxisomal Thiolase Chain A, domain 1CATH (4.3.0)
A3.30.70.3290 Alpha Beta 2-Layer Sandwich Alpha-Beta Plaits CATH (4.3.0)
A3.40.366.10 Alpha Beta 3-Layer(aba) Sandwich Malonyl-Coenzyme A Acyl Carrier Protein domain 2CATH (4.3.0)
B3.40.47.10 Alpha Beta 3-Layer(aba) Sandwich Peroxisomal Thiolase Chain A, domain 1CATH (4.3.0)
B3.30.70.3290 Alpha Beta 2-Layer Sandwich Alpha-Beta Plaits CATH (4.3.0)
B3.40.366.10 Alpha Beta 3-Layer(aba) Sandwich Malonyl-Coenzyme A Acyl Carrier Protein domain 2CATH (4.3.0)
C3.40.47.10 Alpha Beta 3-Layer(aba) Sandwich Peroxisomal Thiolase Chain A, domain 1CATH (4.3.0)
C3.30.70.3290 Alpha Beta 2-Layer Sandwich Alpha-Beta Plaits CATH (4.3.0)
C3.40.366.10 Alpha Beta 3-Layer(aba) Sandwich Malonyl-Coenzyme A Acyl Carrier Protein domain 2CATH (4.3.0)
D3.40.47.10 Alpha Beta 3-Layer(aba) Sandwich Peroxisomal Thiolase Chain A, domain 1CATH (4.3.0)
D3.30.70.3290 Alpha Beta 2-Layer Sandwich Alpha-Beta Plaits CATH (4.3.0)
D3.40.366.10 Alpha Beta 3-Layer(aba) Sandwich Malonyl-Coenzyme A Acyl Carrier Protein domain 2CATH (4.3.0)
E3.40.47.10 Alpha Beta 3-Layer(aba) Sandwich Peroxisomal Thiolase Chain A, domain 1CATH (4.3.0)
E3.30.70.3290 Alpha Beta 2-Layer Sandwich Alpha-Beta Plaits CATH (4.3.0)
E3.40.366.10 Alpha Beta 3-Layer(aba) Sandwich Malonyl-Coenzyme A Acyl Carrier Protein domain 2CATH (4.3.0)
F3.40.47.10 Alpha Beta 3-Layer(aba) Sandwich Peroxisomal Thiolase Chain A, domain 1CATH (4.3.0)
F3.30.70.3290 Alpha Beta 2-Layer Sandwich Alpha-Beta Plaits CATH (4.3.0)
F3.40.366.10 Alpha Beta 3-Layer(aba) Sandwich Malonyl-Coenzyme A Acyl Carrier Protein domain 2CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B, C, D, E
PF02801Beta-ketoacyl synthase, C-terminal domain (Ketoacyl-synt_C)Beta-ketoacyl synthase, C-terminal domainThe structure of beta-ketoacyl synthase is similar to that of the thiolase family (Pfam:PF00108) and also chalcone synthase. The active site of beta-ketoacyl synthase is located between the N and C-terminal domains.Domain
A, B, C, D, E
PF00109Beta-ketoacyl synthase, N-terminal domain (ketoacyl-synt)Beta-ketoacyl synthase, N-terminal domainThe structure of beta-ketoacyl synthase is similar to that of the thiolase family (Pfam:PF00108) and also chalcone synthase. The active site of beta-ketoacyl synthase is located between the N and C-terminal domains. The N-terminal domain contains m ...The structure of beta-ketoacyl synthase is similar to that of the thiolase family (Pfam:PF00108) and also chalcone synthase. The active site of beta-ketoacyl synthase is located between the N and C-terminal domains. The N-terminal domain contains most of the structures involved in dimer formation and also the active site cysteine [1].
Domain
A, B, C, D, E
PF16197Ketoacyl-synthetase C-terminal extension (KAsynt_C_assoc)Ketoacyl-synthetase C-terminal extension- Family
A, B, C, D, E
PF08990Erythronolide synthase docking domain (Docking)Erythronolide synthase docking domainPolyketide synthase (PKS) catalyzes the biosynthesis of polyketides, which are structurally and functionally diverse natural products in microorganisms and plants [1]. Type I modular PKSs are the large, multifunctional enzymes responsible for the pro ...Polyketide synthase (PKS) catalyzes the biosynthesis of polyketides, which are structurally and functionally diverse natural products in microorganisms and plants [1]. Type I modular PKSs are the large, multifunctional enzymes responsible for the production of a diverse family of structurally rich and often biologically active natural products. The efficiency of acyl transfer at the interfaces of the individual PKS proteins is thought to be governed by helical regions, termed docking domains (dd). Two such N-terminal domains dimerise to form amphipathic parallel alpha-helical coiled coils: dimerisation is essential for protein function [1].
Domain
A, B, C, D, E
PF00698Acyl transferase domain (Acyl_transf_1)Acyl transferase domain- Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B, C, D, E
6-Deoxyerythronolide B Synthase

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A, B, C, D, E
IPR016035Acyl transferase/acyl hydrolase/lysophospholipaseHomologous Superfamily
A, B, C, D, E
IPR014031Beta-ketoacyl synthase, C-terminalDomain
A, B, C, D, E
IPR006162Phosphopantetheine attachment sitePTM
A, B, C, D, E
IPR013968Polyketide synthase, ketoreductase domainDomain
A, B, C, D, E
IPR016036Malonyl-CoA ACP transacylase, ACP-bindingHomologous Superfamily
A, B, C, D, E
IPR050091Polyketide and Nonribosomal Peptide Biosynthesis EnzymesFamily
A, B, C, D, E
IPR020806Polyketide synthase, phosphopantetheine-binding domainDomain
A, B, C, D, E
IPR020841Polyketide synthase, beta-ketoacyl synthase domainDomain
A, B, C, D, E
IPR036736ACP-like superfamilyHomologous Superfamily
A, B, C, D, E
IPR014043Acyl transferase domainDomain
A, B, C, D, E
IPR015083Polyketide synthase, docking domainDomain
A, B, C, D, E
IPR032821Polyketide synthase, C-terminal extensionDomain
A, B, C, D, E
IPR009081Phosphopantetheine binding ACP domainDomain
A, B, C, D, E
IPR036299Polyketide synthase, docking domain superfmailyHomologous Superfamily
A, B, C, D, E
IPR029058Alpha/Beta hydrolase foldHomologous Superfamily
A, B, C, D, E
IPR020802Polyketide synthase, thioesterase domainDomain
A, B, C, D, E
IPR016039Thiolase-likeHomologous Superfamily
A, B, C, D, E
IPR001227Acyl transferase domain superfamilyHomologous Superfamily
A, B, C, D, E
IPR036291NAD(P)-binding domain superfamilyHomologous Superfamily
A, B, C, D, E
IPR018201Beta-ketoacyl synthase, active siteActive Site
A, B, C, D, E
IPR014030Beta-ketoacyl synthase-like, N-terminalDomain
A, B, C, D, E
IPR001031ThioesteraseDomain