Annotations: 2HP0

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	MmgE_PrpD_1st	e2hp0A1	A: alpha arrays	X: alpha-helical domain in 2-methylcitrate dehydratase PrpD (From Topology)	H: alpha-helical domain in 2-methylcitrate dehydratase PrpD (From Topology)	T: alpha-helical domain in 2-methylcitrate dehydratase PrpD	F: MmgE_PrpD_1st	ECOD (1.6)
A	UNK_F_TYPE	e2hp0A2	A: a+b two layers	X: FwdE/GAPDH domain-like	H: Serine dehydratase beta chain-like (From Topology)	T: Serine dehydratase beta chain-like	F: UNK_F_TYPE	ECOD (1.6)
B	MmgE_PrpD_1st	e2hp0B2	A: alpha arrays	X: alpha-helical domain in 2-methylcitrate dehydratase PrpD (From Topology)	H: alpha-helical domain in 2-methylcitrate dehydratase PrpD (From Topology)	T: alpha-helical domain in 2-methylcitrate dehydratase PrpD	F: MmgE_PrpD_1st	ECOD (1.6)
B	UNK_F_TYPE	e2hp0B1	A: a+b two layers	X: FwdE/GAPDH domain-like	H: Serine dehydratase beta chain-like (From Topology)	T: Serine dehydratase beta chain-like	F: UNK_F_TYPE	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.4100.10	Mainly Alpha	Orthogonal Bundle	2-methylcitrate dehydratase PrpD	2-methylcitrate dehydratase PrpD	CATH (4.3.0)
A	3.30.1330.120	Alpha Beta	2-Layer Sandwich	60s Ribosomal Protein L30	Chain: A	CATH (4.3.0)
B	1.10.4100.10	Mainly Alpha	Orthogonal Bundle	2-methylcitrate dehydratase PrpD	2-methylcitrate dehydratase PrpD	CATH (4.3.0)
B	3.30.1330.120	Alpha Beta	2-Layer Sandwich	60s Ribosomal Protein L30	Chain: A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF19305	MmgE/PrpD C-terminal domain (MmgE_PrpD_C)	MmgE/PrpD C-terminal domain	This entry represents the C-terminal domain of 2-methylcitrate dehydratase EC:4.2.1.79 (PrpD) that is required for propionate catabolism. It catalyses the third step of the 2-methylcitric acid cycle. This domain is related to the serine dehydratase b ...	This entry represents the C-terminal domain of 2-methylcitrate dehydratase EC:4.2.1.79 (PrpD) that is required for propionate catabolism. It catalyses the third step of the 2-methylcitric acid cycle. This domain is related to the serine dehydratase beta chain.	Domain
A	PF03972	MmgE/PrpD N-terminal domain (MmgE_PrpD_N)	MmgE/PrpD N-terminal domain	This entry represents the N-terminal domain of 2-methylcitrate dehydratase EC:4.2.1.79 (PrpD) that is required for propionate catabolism. It catalyses the third step of the 2-methylcitric acid cycle [1]. This enzyme consists of two domains: a large d ...	This entry represents the N-terminal domain of 2-methylcitrate dehydratase EC:4.2.1.79 (PrpD) that is required for propionate catabolism. It catalyses the third step of the 2-methylcitric acid cycle [1]. This enzyme consists of two domains: a large domain with an all-helical fold and a smaller domain that folds into an alpha/beta domain [2]. Cis-aconitic acid decarboxylase (CAD) shares high identity with proteins of the MmgE/PrpD family [3,4]. Citrate/2-methylcitrate dehydratase from Bacillus subtilis is involved in the tricarboxylic acid (TCA) and methylcitric acid cycles as it has both 2-methylcitrate dehydratase and citrate dehydratase activities [5]. This entry represents the N-terminal domain of 2-methylcitrate dehydratase PrpD, which has an all-helical fold.	Domain
B	PF19305	MmgE/PrpD C-terminal domain (MmgE_PrpD_C)	MmgE/PrpD C-terminal domain	This entry represents the C-terminal domain of 2-methylcitrate dehydratase EC:4.2.1.79 (PrpD) that is required for propionate catabolism. It catalyses the third step of the 2-methylcitric acid cycle. This domain is related to the serine dehydratase b ...	This entry represents the C-terminal domain of 2-methylcitrate dehydratase EC:4.2.1.79 (PrpD) that is required for propionate catabolism. It catalyses the third step of the 2-methylcitric acid cycle. This domain is related to the serine dehydratase beta chain.	Domain
B	PF03972	MmgE/PrpD N-terminal domain (MmgE_PrpD_N)	MmgE/PrpD N-terminal domain	This entry represents the N-terminal domain of 2-methylcitrate dehydratase EC:4.2.1.79 (PrpD) that is required for propionate catabolism. It catalyses the third step of the 2-methylcitric acid cycle [1]. This enzyme consists of two domains: a large d ...	This entry represents the N-terminal domain of 2-methylcitrate dehydratase EC:4.2.1.79 (PrpD) that is required for propionate catabolism. It catalyses the third step of the 2-methylcitric acid cycle [1]. This enzyme consists of two domains: a large domain with an all-helical fold and a smaller domain that folds into an alpha/beta domain [2]. Cis-aconitic acid decarboxylase (CAD) shares high identity with proteins of the MmgE/PrpD family [3,4]. Citrate/2-methylcitrate dehydratase from Bacillus subtilis is involved in the tricarboxylic acid (TCA) and methylcitric acid cycles as it has both 2-methylcitrate dehydratase and citrate dehydratase activities [5]. This entry represents the N-terminal domain of 2-methylcitrate dehydratase PrpD, which has an all-helical fold.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	IDS-epimerase	lyase activity catalytic activity	-	-
B	IDS-epimerase	lyase activity catalytic activity	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR005656	MmgE/PrpD	Family
A	IPR036148	MmgE/PrpD superfamily	Homologous Superfamily
A	IPR042188	MmgE/PrpD superfamily, domain 2	Homologous Superfamily
A	IPR042183	MmgE/PrpD superfamily, domain 1	Homologous Superfamily
A	IPR045337	MmgE/PrpD, C-terminal	Domain
A	IPR045336	MmgE/PrpD, N-terminal	Domain
B	IPR005656	MmgE/PrpD	Family
B	IPR036148	MmgE/PrpD superfamily	Homologous Superfamily
B	IPR042188	MmgE/PrpD superfamily, domain 2	Homologous Superfamily
B	IPR042183	MmgE/PrpD superfamily, domain 1	Homologous Superfamily
B	IPR045337	MmgE/PrpD, C-terminal	Domain
B	IPR045336	MmgE/PrpD, N-terminal	Domain

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
A	MSE	Parent Component: MET
B	CSO	Parent Component: CYS RESID: AA0205 PSI-MOD : L-cysteine sulfenic acid MOD:00210
B	MSE	Parent Component: MET RESID: AA0205

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.