2II4

Crystal structure of a cubic core of the dihydrolipoamide acyltransferase (E2b) component in the branched-chain alpha-ketoacid dehydrogenase complex (BCKDC), Coenzyme A-bound form

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2ii4a_	Alpha and beta proteins (a/b)	CoA-dependent acyltransferases	CoA-dependent acyltransferases	automated matches	automated matches	cattle (Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
B	d2ii4b_	Alpha and beta proteins (a/b)	CoA-dependent acyltransferases	CoA-dependent acyltransferases	automated matches	automated matches	cattle (Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
C	d2ii4c_	Alpha and beta proteins (a/b)	CoA-dependent acyltransferases	CoA-dependent acyltransferases	automated matches	automated matches	cattle (Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
D	d2ii4d_	Alpha and beta proteins (a/b)	CoA-dependent acyltransferases	CoA-dependent acyltransferases	automated matches	automated matches	cattle (Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
E	d2ii4e_	Alpha and beta proteins (a/b)	CoA-dependent acyltransferases	CoA-dependent acyltransferases	automated matches	automated matches	cattle (Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
F	d2ii4f_	Alpha and beta proteins (a/b)	CoA-dependent acyltransferases	CoA-dependent acyltransferases	automated matches	automated matches	cattle (Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
G	d2ii4g_	Alpha and beta proteins (a/b)	CoA-dependent acyltransferases	CoA-dependent acyltransferases	automated matches	automated matches	cattle (Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
H	d2ii4h_	Alpha and beta proteins (a/b)	CoA-dependent acyltransferases	CoA-dependent acyltransferases	automated matches	automated matches	cattle (Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	CoA-dependent acyltransferases	8076201	3000272	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	CoA-dependent acyltransferases	8076201	3000272	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	CoA-dependent acyltransferases	8076201	3000272	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	CoA-dependent acyltransferases	8076201	3000272	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	CoA-dependent acyltransferases	8076201	3000272	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	CoA-dependent acyltransferases	8076201	3000272	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	CoA-dependent acyltransferases	8076201	3000272	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	CoA-dependent acyltransferases	8076201	3000272	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	2-oxoacid_dh	e2ii4A1	A: a+b complex topology	X: CoA-dependent acyltransferases (From Topology)	H: CoA-dependent acyltransferases (From Topology)	T: CoA-dependent acyltransferases	F: 2-oxoacid_dh	ECOD (1.6)
B	2-oxoacid_dh	e2ii4B1	A: a+b complex topology	X: CoA-dependent acyltransferases (From Topology)	H: CoA-dependent acyltransferases (From Topology)	T: CoA-dependent acyltransferases	F: 2-oxoacid_dh	ECOD (1.6)
C	2-oxoacid_dh	e2ii4C1	A: a+b complex topology	X: CoA-dependent acyltransferases (From Topology)	H: CoA-dependent acyltransferases (From Topology)	T: CoA-dependent acyltransferases	F: 2-oxoacid_dh	ECOD (1.6)
D	2-oxoacid_dh	e2ii4D1	A: a+b complex topology	X: CoA-dependent acyltransferases (From Topology)	H: CoA-dependent acyltransferases (From Topology)	T: CoA-dependent acyltransferases	F: 2-oxoacid_dh	ECOD (1.6)
E	2-oxoacid_dh	e2ii4E1	A: a+b complex topology	X: CoA-dependent acyltransferases (From Topology)	H: CoA-dependent acyltransferases (From Topology)	T: CoA-dependent acyltransferases	F: 2-oxoacid_dh	ECOD (1.6)
F	2-oxoacid_dh	e2ii4F1	A: a+b complex topology	X: CoA-dependent acyltransferases (From Topology)	H: CoA-dependent acyltransferases (From Topology)	T: CoA-dependent acyltransferases	F: 2-oxoacid_dh	ECOD (1.6)
G	2-oxoacid_dh	e2ii4G1	A: a+b complex topology	X: CoA-dependent acyltransferases (From Topology)	H: CoA-dependent acyltransferases (From Topology)	T: CoA-dependent acyltransferases	F: 2-oxoacid_dh	ECOD (1.6)
H	2-oxoacid_dh	e2ii4H1	A: a+b complex topology	X: CoA-dependent acyltransferases (From Topology)	H: CoA-dependent acyltransferases (From Topology)	T: CoA-dependent acyltransferases	F: 2-oxoacid_dh	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.559.10	Alpha Beta	2-Layer Sandwich	Chloramphenicol Acetyltransferase	Chloramphenicol acetyltransferase-like domain	CATH (4.3.0)
B	3.30.559.10	Alpha Beta	2-Layer Sandwich	Chloramphenicol Acetyltransferase	Chloramphenicol acetyltransferase-like domain	CATH (4.3.0)
C	3.30.559.10	Alpha Beta	2-Layer Sandwich	Chloramphenicol Acetyltransferase	Chloramphenicol acetyltransferase-like domain	CATH (4.3.0)
D	3.30.559.10	Alpha Beta	2-Layer Sandwich	Chloramphenicol Acetyltransferase	Chloramphenicol acetyltransferase-like domain	CATH (4.3.0)
E	3.30.559.10	Alpha Beta	2-Layer Sandwich	Chloramphenicol Acetyltransferase	Chloramphenicol acetyltransferase-like domain	CATH (4.3.0)
F	3.30.559.10	Alpha Beta	2-Layer Sandwich	Chloramphenicol Acetyltransferase	Chloramphenicol acetyltransferase-like domain	CATH (4.3.0)
G	3.30.559.10	Alpha Beta	2-Layer Sandwich	Chloramphenicol Acetyltransferase	Chloramphenicol acetyltransferase-like domain	CATH (4.3.0)
H	3.30.559.10	Alpha Beta	2-Layer Sandwich	Chloramphenicol Acetyltransferase	Chloramphenicol acetyltransferase-like domain	CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H	Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex	acetyltransferase activity acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity catalytic activity fatty acid binding organic acid binding binding ion binding organic cyclic compound binding anion binding lipid binding lipoic acid binding carboxylic acid binding acetyltransferase activity acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity catalytic activity fatty acid binding organic acid binding binding ion binding organic cyclic compound binding anion binding lipid binding lipoic acid binding carboxylic acid binding heterocyclic compound binding monocarboxylic acid binding small molecule binding sulfur compound binding dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity	-	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle membrane-enclosed lumen mitochondrial matrix intracellular organelle lumen organelle lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H	IPR001078	2-oxoacid dehydrogenase acyltransferase, catalytic domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR023213	Chloramphenicol acetyltransferase-like domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR036625	E3-binding domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR050743	2-oxoacid dehydrogenase family, E2 component	Family
A, B, C, D, E A, B, C, D, E, F, G, H	IPR004167	Peripheral subunit-binding domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR011053	Single hybrid motif	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR003016	2-oxo acid dehydrogenase, lipoyl-binding site	Binding Site
A, B, C, D, E A, B, C, D, E, F, G, H	IPR000089	Biotin/lipoyl attachment	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.