2IWL

Structure of the PX Domain of Phosphoinositide 3-Kinase-C2alpha

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A [auth X]	d2iwlx_	Alpha and beta proteins (a+b)	PX domain	PX domain	automated matches	automated matches	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth X]	SCOP2B Superfamily	PX domain	8077561	3001006	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth X]	PX	e2iwlX1	A: a+b two layers	X: PX domain (From Topology)	H: PX domain (From Topology)	T: PX domain	F: PX	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth X]	3.30.1520.10	Alpha Beta	2-Layer Sandwich	PX Domain	Phox-like domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth X]	PF00787	PX domain (PX)	PX domain	PX domains bind to phosphoinositides.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth X]	PHOSPHATIDYLINOSITOL-4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING ALPHA POLYPEPTIDE	binding phospholipid binding lipid binding phosphatidylinositol binding phosphatidylinositol kinase activity kinase activity lipid kinase activity transferase activity catalytic activity 1-phosphatidylinositol-3-kinase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups 1-phosphatidylinositol-4-phosphate 3-kinase activity adenyl ribonucleotide binding binding phospholipid binding lipid binding phosphatidylinositol binding phosphatidylinositol kinase activity kinase activity lipid kinase activity transferase activity catalytic activity 1-phosphatidylinositol-3-kinase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups 1-phosphatidylinositol-4-phosphate 3-kinase activity adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding clathrin binding protein binding 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity	phosphatidylinositol metabolic process glycerophospholipid biosynthetic process phosphatidylinositol-3-phosphate biosynthetic process glycerophospholipid metabolic process lipid biosynthetic process primary metabolic process phosphatidylinositol phosphate biosynthetic process phospholipid biosynthetic process phosphatidylinositol biosynthetic process phospholipid metabolic process biosynthetic process glycerolipid biosynthetic process organophosphate metabolic process organophosphate biosynthetic process phosphate-containing compound metabolic process phosphatidylinositol metabolic process glycerophospholipid biosynthetic process phosphatidylinositol-3-phosphate biosynthetic process glycerophospholipid metabolic process lipid biosynthetic process primary metabolic process phosphatidylinositol phosphate biosynthetic process phospholipid biosynthetic process phosphatidylinositol biosynthetic process phospholipid metabolic process biosynthetic process glycerolipid biosynthetic process organophosphate metabolic process organophosphate biosynthetic process phosphate-containing compound metabolic process metabolic process cellular process glycerolipid metabolic process phosphorus metabolic process lipid metabolic process cellular response to stimulus regulation of biological process regulation of cellular process cell surface receptor signaling pathway response to stimulus signaling platelet-derived growth factor receptor signaling pathway biological regulation cell surface receptor protein tyrosine kinase signaling pathway cell communication signal transduction enzyme-linked receptor protein signaling pathway intracellular signal transduction phosphatidylinositol-mediated signaling ERBB signaling pathway epidermal growth factor receptor signaling pathway phosphorylation positive regulation of autophagy catabolic process autophagy positive regulation of biological process regulation of catabolic process regulation of autophagy positive regulation of catabolic process positive regulation of metabolic process process utilizing autophagic mechanism regulation of metabolic process positive regulation of cellular process multicellular organismal process positive regulation of locomotion regulation of cell motility cell migration involved in sprouting angiogenesis regulation of blood vessel endothelial cell migration endothelial cell migration angiogenesis positive regulation of cell migration multicellular organism development tube morphogenesis positive regulation of cell motility anatomical structure development regulation of cell migration blood vessel endothelial cell migration regulation of endothelial cell migration cell migration positive regulation of cell migration involved in sprouting angiogenesis cell motility locomotion blood vessel development system development developmental process blood vessel morphogenesis tube development regulation of cell migration involved in sprouting angiogenesis sprouting angiogenesis vasculature development circulatory system development positive regulation of blood vessel endothelial cell migration anatomical structure morphogenesis regulation of locomotion positive regulation of endothelial cell migration anatomical structure formation involved in morphogenesis intracellular signaling cassette phosphatidylinositol 3-kinase/protein kinase B signal transduction localization import into cell transport endocytosis establishment of localization vesicle-mediated transport regulation of tube diameter vascular associated smooth muscle contraction system process regulation of tube size muscle contraction muscle system process circulatory system process smooth muscle contraction vascular process in circulatory system blood vessel diameter maintenance regulation of biological quality vasoconstriction blood circulation regulation of anatomical structure size cellular response to nitrogen compound response to peptide hormone insulin receptor signaling pathway cellular response to endogenous stimulus response to hormone cellular response to hormone stimulus response to endogenous stimulus response to oxygen-containing compound cellular response to peptide hormone stimulus response to nitrogen compound cellular response to oxygen-containing compound cellular response to chemical stimulus response to chemical response to insulin cellular response to insulin stimulus clathrin coat assembly cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular component organization or biogenesis membrane organization secretion by cell exocytosis secretion export from cell	cellular anatomical structure membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol cellular anatomical structure membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol Golgi apparatus subcompartment Golgi apparatus organelle subcompartment intracellular membrane-bounded organelle endomembrane system intracellular organelle trans-Golgi network phosphatidylinositol 3-kinase complex transferase complex, transferring phosphorus-containing groups protein-containing complex catalytic complex membrane protein complex transferase complex extrinsic component of membrane intracellular vesicle cytoplasmic vesicle clathrin-coated vesicle coated vesicle cell periphery plasma membrane nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth X]	IPR015433	Phosphatidylinositol kinase	Family
A [auth X]	IPR016024	Armadillo-type fold	Homologous Superfamily
A [auth X]	IPR002420	C2 phosphatidylinositol 3-kinase-type domain	Domain
A [auth X]	IPR001683	Phox homology	Domain
A [auth X]	IPR000008	C2 domain	Domain
A [auth X]	IPR042133	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha, PX domain	Domain
A [auth X]	IPR018936	Phosphatidylinositol 3/4-kinase, conserved site	Conserved Site
A [auth X]	IPR000403	Phosphatidylinositol 3-/4-kinase, catalytic domain	Domain
A [auth X]	IPR001263	Phosphoinositide 3-kinase, accessory (PIK) domain	Domain
A [auth X]	IPR042236	Phosphoinositide 3-kinase, accessory (PIK) domain superfamily	Homologous Superfamily
A [auth X]	IPR036940	Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily	Homologous Superfamily
A [auth X]	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A [auth X]	IPR036871	PX domain superfamily	Homologous Superfamily
A [auth X]	IPR000341	Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain	Domain
A [auth X]	IPR035892	C2 domain superfamily	Homologous Superfamily
A [auth X]	IPR037705	PI3K-C2-alpha, catalytic domain	Domain
A [auth X]	IPR029071	Ubiquitin-like domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth X]	Pharos: O00443	myopathy astrocytic tumor coronary artery disease juvenile dermatomyositis malignant pancreatic neoplasm neuroleptic malignant syndrome primary angle-closure glaucoma psoriasis atypical teratoid rhabdoid tumor Emery-Dreifuss muscular dystrophy large cell medulloblastoma medulloblastoma osteosarcoma primitive neuroectodermal tumor cataract myopathy astrocytic tumor coronary artery disease juvenile dermatomyositis malignant pancreatic neoplasm neuroleptic malignant syndrome primary angle-closure glaucoma psoriasis atypical teratoid rhabdoid tumor Emery-Dreifuss muscular dystrophy large cell medulloblastoma medulloblastoma osteosarcoma primitive neuroectodermal tumor cataract glioblastoma malignant ependymoma pancreatic ductal adenocarcinoma progressive supranuclear palsy

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.