2IZY

Molecular Basis of AKAP Specificity for PKA Regulatory Subunits

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2izya2	All alpha proteins	Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	automated matches	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
A	d2izya3	Artifacts	Tags	Tags	Tags	C-terminal Tags	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
B	d2izyb2	All alpha proteins	Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	automated matches	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
B	d2izyb3	Artifacts	Tags	Tags	Tags	C-terminal Tags	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
C	d2izyc2	All alpha proteins	Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	automated matches	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
C	d2izyc3	Artifacts	Tags	Tags	Tags	C-terminal Tags	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
D	d2izyd2	All alpha proteins	Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	automated matches	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
D	d2izyd3	Artifacts	Tags	Tags	Tags	C-terminal Tags	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
E	d2izye2	All alpha proteins	Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	automated matches	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
E	d2izye3	Artifacts	Tags	Tags	Tags	C-terminal Tags	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
F	d2izyf2	All alpha proteins	Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	automated matches	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
F	d2izyf3	Artifacts	Tags	Tags	Tags	C-terminal Tags	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
G	d2izyg2	All alpha proteins	Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	automated matches	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
G	d2izyg3	Artifacts	Tags	Tags	Tags	C-terminal Tags	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
H	d2izyh2	All alpha proteins	Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	automated matches	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
H	d2izyh3	Artifacts	Tags	Tags	Tags	C-terminal Tags	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Dpy-30/Rlla-like	8077010	3001874	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Dpy-30/Rlla-like	8077010	3001874	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Dpy-30/Rlla-like	8077010	3001874	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Dpy-30/Rlla-like	8077010	3001874	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Dpy-30/Rlla-like	8077010	3001874	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Dpy-30/Rlla-like	8077010	3001874	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Dpy-30/Rlla-like	8077010	3001874	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Dpy-30/Rlla-like	8077010	3001874	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	RIIa	e2izyA1	A: alpha duplicates or obligate multimers	X: Dimerization-anchoring domain of cAMP-dependent type II PK regulatory subunit (From Topology)	H: Dimerization-anchoring domain of cAMP-dependent type II PK regulatory subunit (From Topology)	T: Dimerization-anchoring domain of cAMP-dependent type II PK regulatory subunit	F: RIIa	ECOD (1.6)
B	RIIa	e2izyB1	A: alpha duplicates or obligate multimers	X: Dimerization-anchoring domain of cAMP-dependent type II PK regulatory subunit (From Topology)	H: Dimerization-anchoring domain of cAMP-dependent type II PK regulatory subunit (From Topology)	T: Dimerization-anchoring domain of cAMP-dependent type II PK regulatory subunit	F: RIIa	ECOD (1.6)
C	RIIa	e2izyC1	A: alpha duplicates or obligate multimers	X: Dimerization-anchoring domain of cAMP-dependent type II PK regulatory subunit (From Topology)	H: Dimerization-anchoring domain of cAMP-dependent type II PK regulatory subunit (From Topology)	T: Dimerization-anchoring domain of cAMP-dependent type II PK regulatory subunit	F: RIIa	ECOD (1.6)
D	RIIa	e2izyD1	A: alpha duplicates or obligate multimers	X: Dimerization-anchoring domain of cAMP-dependent type II PK regulatory subunit (From Topology)	H: Dimerization-anchoring domain of cAMP-dependent type II PK regulatory subunit (From Topology)	T: Dimerization-anchoring domain of cAMP-dependent type II PK regulatory subunit	F: RIIa	ECOD (1.6)
E	RIIa	e2izyE1	A: alpha duplicates or obligate multimers	X: Dimerization-anchoring domain of cAMP-dependent type II PK regulatory subunit (From Topology)	H: Dimerization-anchoring domain of cAMP-dependent type II PK regulatory subunit (From Topology)	T: Dimerization-anchoring domain of cAMP-dependent type II PK regulatory subunit	F: RIIa	ECOD (1.6)
F	RIIa	e2izyF1	A: alpha duplicates or obligate multimers	X: Dimerization-anchoring domain of cAMP-dependent type II PK regulatory subunit (From Topology)	H: Dimerization-anchoring domain of cAMP-dependent type II PK regulatory subunit (From Topology)	T: Dimerization-anchoring domain of cAMP-dependent type II PK regulatory subunit	F: RIIa	ECOD (1.6)
G	RIIa	e2izyG1	A: alpha duplicates or obligate multimers	X: Dimerization-anchoring domain of cAMP-dependent type II PK regulatory subunit (From Topology)	H: Dimerization-anchoring domain of cAMP-dependent type II PK regulatory subunit (From Topology)	T: Dimerization-anchoring domain of cAMP-dependent type II PK regulatory subunit	F: RIIa	ECOD (1.6)
H	RIIa	e2izyH1	A: alpha duplicates or obligate multimers	X: Dimerization-anchoring domain of cAMP-dependent type II PK regulatory subunit (From Topology)	H: Dimerization-anchoring domain of cAMP-dependent type II PK regulatory subunit (From Topology)	T: Dimerization-anchoring domain of cAMP-dependent type II PK regulatory subunit	F: RIIa	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.890.10	Mainly Alpha	Up-down Bundle	cAMP-dependent Protein Kinase, Chain A	cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain	CATH (4.3.0)
B	1.20.890.10	Mainly Alpha	Up-down Bundle	cAMP-dependent Protein Kinase, Chain A	cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain	CATH (4.3.0)
C	1.20.890.10	Mainly Alpha	Up-down Bundle	cAMP-dependent Protein Kinase, Chain A	cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain	CATH (4.3.0)
D	1.20.890.10	Mainly Alpha	Up-down Bundle	cAMP-dependent Protein Kinase, Chain A	cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain	CATH (4.3.0)
E	1.20.890.10	Mainly Alpha	Up-down Bundle	cAMP-dependent Protein Kinase, Chain A	cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain	CATH (4.3.0)
F	1.20.890.10	Mainly Alpha	Up-down Bundle	cAMP-dependent Protein Kinase, Chain A	cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain	CATH (4.3.0)
G	1.20.890.10	Mainly Alpha	Up-down Bundle	cAMP-dependent Protein Kinase, Chain A	cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain	CATH (4.3.0)
H	1.20.890.10	Mainly Alpha	Up-down Bundle	cAMP-dependent Protein Kinase, Chain A	cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H	PF02197	Regulatory subunit of type II PKA R-subunit (RIIa)	Regulatory subunit of type II PKA R-subunit	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H	CAMP-DEPENDENT PROTEIN KINASE REGULATORY SUBUNIT II	protein binding binding protein domain specific binding enzyme regulator activity enzyme inhibitor activity protein kinase regulator activity cAMP-dependent protein kinase regulator activity protein kinase inhibitor activity molecular function inhibitor activity molecular function regulator activity cAMP-dependent protein kinase inhibitor activity protein serine/threonine kinase inhibitor activity kinase inhibitor activity kinase regulator activity protein binding binding protein domain specific binding enzyme regulator activity enzyme inhibitor activity protein kinase regulator activity cAMP-dependent protein kinase regulator activity protein kinase inhibitor activity molecular function inhibitor activity molecular function regulator activity cAMP-dependent protein kinase inhibitor activity protein serine/threonine kinase inhibitor activity kinase inhibitor activity kinase regulator activity beta-2 adrenergic receptor binding adrenergic receptor binding signaling receptor binding G protein-coupled receptor binding small molecule binding adenyl ribonucleotide binding cyclic nucleotide binding nucleotide binding purine ribonucleotide binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding cAMP binding adenyl nucleotide binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding protein-containing complex binding protein kinase A catalytic subunit binding protein kinase A binding kinase binding enzyme binding protein kinase binding identical protein binding	trans-synaptic signaling regulation of biological process regulation of signaling regulation of cellular process modulation of chemical synaptic transmission signaling biological regulation cell-cell signaling chemical synaptic transmission cell communication synaptic signaling regulation of trans-synaptic signaling anterograde trans-synaptic signaling regulation of cell communication trans-synaptic signaling regulation of biological process regulation of signaling regulation of cellular process modulation of chemical synaptic transmission signaling biological regulation cell-cell signaling chemical synaptic transmission cell communication synaptic signaling regulation of trans-synaptic signaling anterograde trans-synaptic signaling regulation of cell communication cellular process regulation of protein modification process regulation of protein phosphorylation regulation of primary metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process protein metabolic process protein modification process phosphorus metabolic process protein phosphorylation phosphorylation regulation of protein metabolic process primary metabolic process regulation of macromolecule metabolic process macromolecule modification metabolic process regulation of phosphorylation regulation of phosphorus metabolic process macromolecule metabolic process regulation of metabolic process	cell periphery cellular anatomical structure sarcolemma plasma membrane membrane T-tubule intracellular anatomical structure cytoplasm cytosol protein-containing complex synapse cell junction glutamatergic synapse perinuclear region of cytoplasm cell periphery cellular anatomical structure sarcolemma plasma membrane membrane T-tubule intracellular anatomical structure cytoplasm cytosol protein-containing complex synapse cell junction glutamatergic synapse perinuclear region of cytoplasm protein kinase complex transferase complex, transferring phosphorus-containing groups catalytic complex cAMP-dependent protein kinase complex serine/threonine protein kinase complex transferase complex intracellular protein-containing complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H	IPR050503	cAMP-dependent kinase regulatory chain	Family
A, B, C, D, E A, B, C, D, E, F, G, H	IPR014710	RmlC-like jelly roll fold	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR018488	Cyclic nucleotide-binding, conserved site	Conserved Site
A, B, C, D, E A, B, C, D, E, F, G, H	IPR003117	cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR000595	Cyclic nucleotide-binding domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR012198	cAMP-dependent protein kinase regulatory subunit	Family
A, B, C, D, E A, B, C, D, E, F, G, H	IPR018490	Cyclic nucleotide-binding domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.