2JBV

Crystal structure of choline oxidase reveals insights into the catalytic mechanism

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	GMC_oxred_C	e2jbvA1	A: a+b two layers	X: FAD-linked reductases, C-terminal domain-like	H: FAD-linked reductases-C (From Topology)	T: FAD-linked reductases-C	F: GMC_oxred_C	ECOD (1.6)
A	GMC_oxred_N	e2jbvA2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: FAD/NAD(P)-binding domain	F: GMC_oxred_N	ECOD (1.6)
B	GMC_oxred_C	e2jbvB2	A: a+b two layers	X: FAD-linked reductases, C-terminal domain-like	H: FAD-linked reductases-C (From Topology)	T: FAD-linked reductases-C	F: GMC_oxred_C	ECOD (1.6)
B	GMC_oxred_N	e2jbvB1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: FAD/NAD(P)-binding domain	F: GMC_oxred_N	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.50.50.60	Alpha Beta	3-Layer(bba) Sandwich	FAD/NAD(P)-binding domain	FAD/NAD(P)-binding domain	CATH (4.3.0)
A	4.10.450.10	Few Secondary Structures	Irregular	Glucose Oxidase	domain 2	CATH (4.3.0)
A	1.10.1220.110	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant		CATH (4.3.0)
A	3.30.410.40	Alpha Beta	2-Layer Sandwich	Cholesterol Oxidase	domain 2	CATH (4.3.0)
B	3.50.50.60	Alpha Beta	3-Layer(bba) Sandwich	FAD/NAD(P)-binding domain	FAD/NAD(P)-binding domain	CATH (4.3.0)
B	4.10.450.10	Few Secondary Structures	Irregular	Glucose Oxidase	domain 2	CATH (4.3.0)
B	1.10.1220.110	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant		CATH (4.3.0)
B	3.30.410.40	Alpha Beta	2-Layer Sandwich	Cholesterol Oxidase	domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00732	GMC oxidoreductase (GMC_oxred_N)	GMC oxidoreductase	This family of proteins bind FAD as a cofactor.	Domain
A, B	PF05199	GMC oxidoreductase (GMC_oxred_C)	GMC oxidoreductase	This domain found associated with Pfam:PF00732.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	CHOLINE OXIDASE	oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor oxidoreductase activity choline:oxygen 1-oxidoreductase activity oxidoreductase activity, acting on CH-OH group of donors catalytic activity flavin adenine dinucleotide binding binding nucleoside phosphate binding ion binding organic cyclic compound binding anion binding nucleotide binding heterocyclic compound binding small molecule binding	amino-acid betaine biosynthetic process cellular metabolic process amino-acid betaine metabolic process cellular modified amino acid metabolic process glycine betaine metabolic process glycine betaine biosynthetic process from choline ammonium ion metabolic process biosynthetic process cellular modified amino acid biosynthetic process choline metabolic process metabolic process cellular process glycine betaine biosynthetic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR000172	Glucose-methanol-choline oxidoreductase, N-terminal	Domain
A, B	IPR012132	Glucose-methanol-choline oxidoreductase	Family
A, B	IPR007867	Glucose-methanol-choline oxidoreductase, C-terminal	Domain
A, B	IPR036188	FAD/NAD(P)-binding domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.