2JEC

crystal structure of recombinant DiocleA grandiflora lectin mutant E123A-H131N-K132Q complexed witH 5-bromo-4-chloro-3-indolyl-a-D- mannose

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2jeca1	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	Legume lectins	automated matches	(Macropsychanthus grandiflorus ) [TaxId: 3837 ],	SCOPe (2.08)
A	d2jeca2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Macropsychanthus grandiflorus ) [TaxId: 3837 ],	SCOPe (2.08)
B	d2jecb1	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	Legume lectins	automated matches	(Macropsychanthus grandiflorus ) [TaxId: 3837 ],	SCOPe (2.08)
B	d2jecb2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Macropsychanthus grandiflorus ) [TaxId: 3837 ],	SCOPe (2.08)
C	d2jecc1	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	Legume lectins	automated matches	(Macropsychanthus grandiflorus ) [TaxId: 3837 ],	SCOPe (2.08)
C	d2jecc2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Macropsychanthus grandiflorus ) [TaxId: 3837 ],	SCOPe (2.08)
D	d2jecd1	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	Legume lectins	automated matches	(Macropsychanthus grandiflorus ) [TaxId: 3837 ],	SCOPe (2.08)
D	d2jecd2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Macropsychanthus grandiflorus ) [TaxId: 3837 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8041357	3000120	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8041357	3000120	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8041357	3000120	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8041357	3000120	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Lectin_legB	e2jecA1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: Lectin_legB	ECOD (1.6)
B	Lectin_legB	e2jecB1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: Lectin_legB	ECOD (1.6)
C	Lectin_legB	e2jecC1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: Lectin_legB	ECOD (1.6)
D	Lectin_legB	e2jecD1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: Lectin_legB	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)
B	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)
C	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)
D	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF00139	Legume lectin domain (Lectin_legB)	Legume lectin domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	LECTIN ALPHA CHAIN	binding carbohydrate binding D-mannose binding monosaccharide binding small molecule binding cation binding ion binding metal ion binding identical protein binding protein binding toxin activity	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily	Homologous Superfamily
A, B, C, D	IPR001220	Legume lectin domain	Domain
A, B, C, D	IPR000985	Legume lectin, alpha chain, conserved site	Conserved Site
A, B, C, D	IPR050258	Leguminous Lectin	Family
A, B, C, D	IPR019825	Legume lectin, beta chain, Mn/Ca-binding site	Binding Site

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.