2OSY

Endo-glycoceramidase II from Rhodococcus sp.: Lactosyl-Enzyme Intermediate

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	EUF07812	e2osyA2	A: beta sandwiches	X: Glycosyl hydrolase domain-like	H: Glycosyl hydrolase domain (From Topology)	T: Glycosyl hydrolase domain	F: EUF07812	ECOD (1.6)
A	Cellulase	e2osyA1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Cellulase	ECOD (1.6)
B	EUF07812	e2osyB1	A: beta sandwiches	X: Glycosyl hydrolase domain-like	H: Glycosyl hydrolase domain (From Topology)	T: Glycosyl hydrolase domain	F: EUF07812	ECOD (1.6)
B	Cellulase	e2osyB2	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Cellulase	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.40.1180	Mainly Beta	Sandwich	Immunoglobulin-like	Golgi alpha-mannosidase II	CATH (4.3.0)
A	3.20.20.80	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Glycosidases	CATH (4.3.0)
B	2.60.40.1180	Mainly Beta	Sandwich	Immunoglobulin-like	Golgi alpha-mannosidase II	CATH (4.3.0)
B	3.20.20.80	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Glycosidases	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF18564	Glycoside hydrolase family 5 C-terminal domain (Glyco_hydro_5_C)	Glycoside hydrolase family 5 C-terminal domain	This is the C-terminal domain of endo-glycoceramidase II (EGC), a membrane-associated family 5 glycosidase Pfam:PF00150. The C-terminal domain assumes a beta-sandwich fold, which resembles that of many carbohydrate-binding modules [1].	Domain
A, B	PF00150	Cellulase (glycosyl hydrolase family 5) (Cellulase)	Cellulase (glycosyl hydrolase family 5)	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Endoglycoceramidase II	hydrolase activity, acting on glycosyl bonds endoglycosylceramidase activity hydrolase activity, hydrolyzing O-glycosyl compounds hydrolase activity catalytic activity	lipid catabolic process catabolic process metabolic process cellular process primary metabolic process lipid metabolic process carbohydrate metabolic process polysaccharide metabolic process polysaccharide catabolic process carbohydrate catabolic process macromolecule metabolic process macromolecule catabolic process carbohydrate derivative catabolic process carbohydrate derivative metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR017853	Glycoside hydrolase superfamily	Homologous Superfamily
A, B	IPR041036	Glycoside hydrolase family 5, C-terminal domain	Domain
A, B	IPR001547	Glycoside hydrolase, family 5	Domain
A, B	IPR018087	Glycoside hydrolase, family 5, conserved site	Conserved Site
A, B	IPR052066	Glycosphingolipid Hydrolyzing Enzymes	Family
A, B	IPR013780	Glycosyl hydrolase, all-beta	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.