2PNO

Crystal structure of human leukotriene C4 synthase

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2pnoa1	Membrane and cell surface proteins and peptides	MAPEG domain-like	MAPEG domain-like	MAPEG domain	Leukotriene C4 synthase	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d2pnob1	Membrane and cell surface proteins and peptides	MAPEG domain-like	MAPEG domain-like	MAPEG domain	Leukotriene C4 synthase	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E	d2pnoe1	Membrane and cell surface proteins and peptides	MAPEG domain-like	MAPEG domain-like	MAPEG domain	Leukotriene C4 synthase	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
F	d2pnof1	Membrane and cell surface proteins and peptides	MAPEG domain-like	MAPEG domain-like	MAPEG domain	Leukotriene C4 synthase	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
I	d2pnoi1	Membrane and cell surface proteins and peptides	MAPEG domain-like	MAPEG domain-like	MAPEG domain	Leukotriene C4 synthase	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
J	d2pnoj1	Membrane and cell surface proteins and peptides	MAPEG domain-like	MAPEG domain-like	MAPEG domain	Leukotriene C4 synthase	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d2pnoc1	Membrane and cell surface proteins and peptides	MAPEG domain-like	MAPEG domain-like	MAPEG domain	Leukotriene C4 synthase	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d2pnod1	Membrane and cell surface proteins and peptides	MAPEG domain-like	MAPEG domain-like	MAPEG domain	Leukotriene C4 synthase	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
G	d2pnog1	Membrane and cell surface proteins and peptides	MAPEG domain-like	MAPEG domain-like	MAPEG domain	Leukotriene C4 synthase	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
H	d2pnoh1	Membrane and cell surface proteins and peptides	MAPEG domain-like	MAPEG domain-like	MAPEG domain	Leukotriene C4 synthase	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
K	d2pnok1	Membrane and cell surface proteins and peptides	MAPEG domain-like	MAPEG domain-like	MAPEG domain	Leukotriene C4 synthase	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
L	d2pnol1	Membrane and cell surface proteins and peptides	MAPEG domain-like	MAPEG domain-like	MAPEG domain	Leukotriene C4 synthase	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	MAPEG domain-like	8036969	3001687	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	MAPEG domain-like	8036969	3001687	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	MAPEG domain-like	8036969	3001687	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	MAPEG domain-like	8036969	3001687	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	MAPEG domain-like	8036969	3001687	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	MAPEG domain-like	8036969	3001687	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	MAPEG domain-like	8036969	3001687	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	MAPEG domain-like	8036969	3001687	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	MAPEG domain-like	8036969	3001687	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	MAPEG domain-like	8036969	3001687	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	MAPEG domain-like	8036969	3001687	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	MAPEG domain-like	8036969	3001687	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	MAPEG	e2pnoA1	A: alpha superhelices	X: Cytochrome c oxidase subunit I-like	H: MAPEG domain-like (From Topology)	T: MAPEG domain-like	F: MAPEG	ECOD (1.6)
B	MAPEG	e2pnoB1	A: alpha superhelices	X: Cytochrome c oxidase subunit I-like	H: MAPEG domain-like (From Topology)	T: MAPEG domain-like	F: MAPEG	ECOD (1.6)
E	MAPEG	e2pnoE1	A: alpha superhelices	X: Cytochrome c oxidase subunit I-like	H: MAPEG domain-like (From Topology)	T: MAPEG domain-like	F: MAPEG	ECOD (1.6)
F	MAPEG	e2pnoF1	A: alpha superhelices	X: Cytochrome c oxidase subunit I-like	H: MAPEG domain-like (From Topology)	T: MAPEG domain-like	F: MAPEG	ECOD (1.6)
I	MAPEG	e2pnoI1	A: alpha superhelices	X: Cytochrome c oxidase subunit I-like	H: MAPEG domain-like (From Topology)	T: MAPEG domain-like	F: MAPEG	ECOD (1.6)
J	MAPEG	e2pnoJ1	A: alpha superhelices	X: Cytochrome c oxidase subunit I-like	H: MAPEG domain-like (From Topology)	T: MAPEG domain-like	F: MAPEG	ECOD (1.6)
C	MAPEG	e2pnoC1	A: alpha superhelices	X: Cytochrome c oxidase subunit I-like	H: MAPEG domain-like (From Topology)	T: MAPEG domain-like	F: MAPEG	ECOD (1.6)
D	MAPEG	e2pnoD1	A: alpha superhelices	X: Cytochrome c oxidase subunit I-like	H: MAPEG domain-like (From Topology)	T: MAPEG domain-like	F: MAPEG	ECOD (1.6)
G	MAPEG	e2pnoG1	A: alpha superhelices	X: Cytochrome c oxidase subunit I-like	H: MAPEG domain-like (From Topology)	T: MAPEG domain-like	F: MAPEG	ECOD (1.6)
H	MAPEG	e2pnoH1	A: alpha superhelices	X: Cytochrome c oxidase subunit I-like	H: MAPEG domain-like (From Topology)	T: MAPEG domain-like	F: MAPEG	ECOD (1.6)
K	MAPEG	e2pnoK1	A: alpha superhelices	X: Cytochrome c oxidase subunit I-like	H: MAPEG domain-like (From Topology)	T: MAPEG domain-like	F: MAPEG	ECOD (1.6)
L	MAPEG	e2pnoL1	A: alpha superhelices	X: Cytochrome c oxidase subunit I-like	H: MAPEG domain-like (From Topology)	T: MAPEG domain-like	F: MAPEG	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.120.550	Mainly Alpha	Up-down Bundle	Four Helix Bundle (Hemerythrin (Met), subunit A)	Membrane associated eicosanoid/glutathione metabolism-like domain	CATH (4.3.0)
B	1.20.120.550	Mainly Alpha	Up-down Bundle	Four Helix Bundle (Hemerythrin (Met), subunit A)	Membrane associated eicosanoid/glutathione metabolism-like domain	CATH (4.3.0)
E	1.20.120.550	Mainly Alpha	Up-down Bundle	Four Helix Bundle (Hemerythrin (Met), subunit A)	Membrane associated eicosanoid/glutathione metabolism-like domain	CATH (4.3.0)
F	1.20.120.550	Mainly Alpha	Up-down Bundle	Four Helix Bundle (Hemerythrin (Met), subunit A)	Membrane associated eicosanoid/glutathione metabolism-like domain	CATH (4.3.0)
I	1.20.120.550	Mainly Alpha	Up-down Bundle	Four Helix Bundle (Hemerythrin (Met), subunit A)	Membrane associated eicosanoid/glutathione metabolism-like domain	CATH (4.3.0)
J	1.20.120.550	Mainly Alpha	Up-down Bundle	Four Helix Bundle (Hemerythrin (Met), subunit A)	Membrane associated eicosanoid/glutathione metabolism-like domain	CATH (4.3.0)
C	1.20.120.550	Mainly Alpha	Up-down Bundle	Four Helix Bundle (Hemerythrin (Met), subunit A)	Membrane associated eicosanoid/glutathione metabolism-like domain	CATH (4.3.0)
D	1.20.120.550	Mainly Alpha	Up-down Bundle	Four Helix Bundle (Hemerythrin (Met), subunit A)	Membrane associated eicosanoid/glutathione metabolism-like domain	CATH (4.3.0)
G	1.20.120.550	Mainly Alpha	Up-down Bundle	Four Helix Bundle (Hemerythrin (Met), subunit A)	Membrane associated eicosanoid/glutathione metabolism-like domain	CATH (4.3.0)
H	1.20.120.550	Mainly Alpha	Up-down Bundle	Four Helix Bundle (Hemerythrin (Met), subunit A)	Membrane associated eicosanoid/glutathione metabolism-like domain	CATH (4.3.0)
K	1.20.120.550	Mainly Alpha	Up-down Bundle	Four Helix Bundle (Hemerythrin (Met), subunit A)	Membrane associated eicosanoid/glutathione metabolism-like domain	CATH (4.3.0)
L	1.20.120.550	Mainly Alpha	Up-down Bundle	Four Helix Bundle (Hemerythrin (Met), subunit A)	Membrane associated eicosanoid/glutathione metabolism-like domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	PF01124	MAPEG family (MAPEG)	MAPEG family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	Leukotriene C4 synthase	enzyme regulator activity enzyme activator activity molecular function activator activity molecular function regulator activity binding lipid binding peroxidase activity oxidoreductase activity antioxidant activity oxidoreductase activity, acting on peroxide as acceptor glutathione peroxidase activity catalytic activity glutathione transferase activity transferase activity enzyme regulator activity enzyme activator activity molecular function activator activity molecular function regulator activity binding lipid binding peroxidase activity oxidoreductase activity antioxidant activity oxidoreductase activity, acting on peroxide as acceptor glutathione peroxidase activity catalytic activity glutathione transferase activity transferase activity transferase activity, transferring alkyl or aryl (other than methyl) groups carbon-sulfur lyase activity leukotriene-C4 synthase activity lyase activity identical protein binding protein binding	icosanoid metabolic process leukotriene metabolic process oxoacid metabolic process small molecule biosynthetic process leukotriene biosynthetic process carboxylic acid metabolic process organic acid metabolic process organic acid biosynthetic process carboxylic acid biosynthetic process biosynthetic process icosanoid biosynthetic process small molecule metabolic process metabolic process cellular process icosanoid metabolic process leukotriene metabolic process oxoacid metabolic process small molecule biosynthetic process leukotriene biosynthetic process carboxylic acid metabolic process organic acid metabolic process organic acid biosynthetic process carboxylic acid biosynthetic process biosynthetic process icosanoid biosynthetic process small molecule metabolic process metabolic process cellular process fatty acid metabolic process long-chain fatty acid metabolic process monocarboxylic acid biosynthetic process long-chain fatty acid biosynthetic process lipid biosynthetic process primary metabolic process fatty acid biosynthetic process monocarboxylic acid metabolic process lipid metabolic process	membrane-bounded organelle nuclear outer membrane intracellular anatomical structure nuclear membrane membrane nucleus organelle outer membrane intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure bounding membrane of organelle organelle membrane-bounded organelle nuclear outer membrane intracellular anatomical structure nuclear membrane membrane nucleus organelle outer membrane intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure bounding membrane of organelle organelle nuclear outer membrane-endoplasmic reticulum membrane network nuclear envelope outer membrane organelle membrane endoplasmic reticulum cytoplasm organelle subcompartment endoplasmic reticulum subcompartment endoplasmic reticulum membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR001129	Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein	Family
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR050997	Membrane-associated proteins in eicosanoid and glutathione metabolism	Family
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR018295	FLAP/GST2/LTC4S, conserved site	Conserved Site
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR023352	Membrane associated eicosanoid/glutathione metabolism-like domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR001446	5-lipoxygenase-activating protein	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	Pharos: Q16873	hypotonia-failure to thrive-microcephaly syndrome Asthma, Aspirin-Induced drug allergy

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	MemProtMD	Annotated as membrane protein by MemProtMD

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.