Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
A [auth B]DNA_methylase_1e2pvcB6 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: S-adenosyl-L-methionine-dependent methyltransferasesF: DNA_methylase_1ECOD (1.6)
A [auth B]ADDz_Dnmt3le2pvcB5 A: few secondary structure elementsX: RING/U-box-likeH: RING/U-box-likeT: FYVE/PHD zinc fingerF: ADDz_Dnmt3lECOD (1.6)
A [auth B]ADDz_Dnmt3be2pvcB4 A: few secondary structure elementsX: RING/U-box-likeH: RING/U-box-likeT: FYVE/PHD zinc fingerF: ADDz_Dnmt3bECOD (1.6)
C [auth A]DNA_methylase_1e2pvcA6 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: S-adenosyl-L-methionine-dependent methyltransferasesF: DNA_methylase_1ECOD (1.6)
C [auth A]ADDz_Dnmt3le2pvcA5 A: few secondary structure elementsX: RING/U-box-likeH: RING/U-box-likeT: FYVE/PHD zinc fingerF: ADDz_Dnmt3lECOD (1.6)
C [auth A]ADDz_Dnmt3be2pvcA4 A: few secondary structure elementsX: RING/U-box-likeH: RING/U-box-likeT: FYVE/PHD zinc fingerF: ADDz_Dnmt3bECOD (1.6)
E [auth C]DNA_methylase_1e2pvcC6 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: S-adenosyl-L-methionine-dependent methyltransferasesF: DNA_methylase_1ECOD (1.6)
E [auth C]ADDz_Dnmt3le2pvcC5 A: few secondary structure elementsX: RING/U-box-likeH: RING/U-box-likeT: FYVE/PHD zinc fingerF: ADDz_Dnmt3lECOD (1.6)
E [auth C]ADDz_Dnmt3be2pvcC4 A: few secondary structure elementsX: RING/U-box-likeH: RING/U-box-likeT: FYVE/PHD zinc fingerF: ADDz_Dnmt3bECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A [auth B],
C [auth A],
E [auth C]
PF21255DNMT3, ADD PHD zinc finger (DNMT3_ADD_GATA1-like)DNMT3, ADD PHD zinc fingerDNMT3s are de novo DNA methyltransferases responsible for the establishment of DNA methylation patterns in mammalian genomes [1-4]. The ATRX-DNMT3-DNMT3L (ADD) domain contains two parts, a C2-C2-like zinc finger (Pfam:PF17980) and a PHD-like zinc fin ...DNMT3s are de novo DNA methyltransferases responsible for the establishment of DNA methylation patterns in mammalian genomes [1-4]. The ATRX-DNMT3-DNMT3L (ADD) domain contains two parts, a C2-C2-like zinc finger (Pfam:PF17980) and a PHD-like zinc finger, represented in this entry. In this domain, the conserved His residue observed in classical PHD zinc fingers is replaced by a cysteine.
Domain
A [auth B],
C [auth A],
E [auth C]
PF17980DNMT3, cysteine rich ADD domain, GATA1-like zinc finger (ADD_DNMT3)DNMT3, cysteine rich ADD domain, GATA1-like zinc fingerThis is a C4-type GATA1-like zinc finger of a cysteine-rich domain termed ADD (ATRX-DNMT3-DNMT3L, AD-DATRX) found in animal DNMT3A proteins. The ADD domains of the DNMT3 family have a decisive role in blocking DNMT activity in the areas of the genome ...This is a C4-type GATA1-like zinc finger of a cysteine-rich domain termed ADD (ATRX-DNMT3-DNMT3L, AD-DATRX) found in animal DNMT3A proteins. The ADD domains of the DNMT3 family have a decisive role in blocking DNMT activity in the areas of the genome with chromatin containing methylated H3K4. This domain contains two parts, a GATA1-like and a PHD-like (Pfam:PF21255) zinc fingers. The DNA methyltransferase (DNMT) 3 family members DNMT3A and the DNMT3-like non-enzymatic regulatory factor DNMT3L, are involved in de-novo establishment of DNA methylation patterns in early mammalian development [1,2].
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A [auth B],
C [auth A],
E [auth C]
DNA (cytosine-5)-methyltransferase 3-like
B [auth D],
D [auth E],
F
Histone H3 peptide---