2QMJ
Crystral Structure of the N-terminal Subunit of Human Maltase-Glucoamylase in Complex with Acarbose
External Resource: Annotation
- Domain Annotation: SCOP/SCOPe Classification
- Domain Annotation: SCOP2 Classification
- Domain Annotation: ECOD Classification
- Domain Annotation: CATH
- Protein Family Annotation
- Gene Ontology: Gene Product Annotation
- InterPro: Protein Family Classification
- Pharos: Disease Associations
- Structure Motif: Primary M-CSA Annotation
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
A | SCOP2B Superfamily | Glycosyl hydrolase domain-like | 8093223 | 3001528 | SCOP2B (2022-06-29) |
A | SCOP2B Superfamily | Galactose mutarotase-like | 8093217 | 3000035 | SCOP2B (2022-06-29) |
A | SCOP2B Superfamily | Trefoil | 8093219 | 3000849 | SCOP2B (2022-06-29) |
A | SCOP2B Superfamily | (Trans)glycosidases | 8093221 | 3000313 | SCOP2B (2022-06-29) |
A | SCOP2B Superfamily | YicI C-terminal domain-like | 8093225 | 3000267 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | Glyco_hydro_31_C | e2qmjA2 | A: beta sandwiches | X: Glycosyl hydrolase domain-like | H: Glycosyl hydrolase domain (From Topology) | T: Glycosyl hydrolase domain | F: Glyco_hydro_31_C | ECOD (1.6) |
A | Gal_mutarotas_2 | e2qmjA5 | A: beta sandwiches | X: Glycosyl hydrolase domain-like | H: supersandwich (From Topology) | T: supersandwich | F: Gal_mutarotas_2 | ECOD (1.6) |
A | DUF5110_1 | e2qmjA4 | A: beta sandwiches | X: Putative glucosidase YicI, C-terminal domain (From Topology) | H: Putative glucosidase YicI, C-terminal domain (From Topology) | T: Putative glucosidase YicI, C-terminal domain | F: DUF5110_1 | ECOD (1.6) |
A | Glyco_hydro_31_N | e2qmjA1 | A: a/b barrels | X: TIM beta/alpha-barrel | H: TIM barrels (From Topology) | T: TIM barrels | F: Glyco_hydro_31_N | ECOD (1.6) |
A | Trefoil | e2qmjA6 | A: few secondary structure elements | X: Trefoil/Plexin domain-like (From Topology) | H: Trefoil/Plexin domain-like (From Topology) | T: Trefoil/Plexin domain-like | F: Trefoil | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A | 4.10.110.10 | Few Secondary Structures | Irregular | Spasmolytic Protein | domain 1 | CATH (4.3.0) |
A | 2.60.40.1760 | Mainly Beta | Sandwich | Immunoglobulin-like | glycosyl hydrolase (family 31) | CATH (4.3.0) |
A | 3.20.20.80 | Alpha Beta | Alpha-Beta Barrel | TIM Barrel | Glycosidases | CATH (4.3.0) |
A | 2.60.40.1180 | Mainly Beta | Sandwich | Immunoglobulin-like | Golgi alpha-mannosidase II | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF21365 | Glycosyl hydrolase family 31 C-terminal domain (Glyco_hydro_31_3rd) | Glycosyl hydrolase family 31 C-terminal domain | Glycosyl hydrolases are key enzymes of carbohydrate metabolism. Family 31 comprises of enzymes that are, or similar to, alpha- galactosidases. This entry represents the 3rd beta sandwich domain. | Domain | |
PF13802 | Glycosyl hydrolase 31 N-terminal galactose mutarotase-like domain (Gal_mutarotas_2) | Glycosyl hydrolase 31 N-terminal galactose mutarotase-like domain | This entry represents the first of three common domains found in Glycosyl hydrolase 31 family proteins. It has a galactose mutarotase superfamily fold. | Domain | |
PF01055 | Glycosyl hydrolases family 31 TIM-barrel domain (Glyco_hydro_31_2nd) | Glycosyl hydrolases family 31 TIM-barrel domain | Glycosyl hydrolases are key enzymes of carbohydrate metabolism. Family 31 comprises of enzymes that are, or similar to, alpha- galactosidases. This entry corresponds to the second domain of family 31 enzymes and adopts a TIM-barrel fold. | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR048395 | Glycosyl hydrolase family 31, C-terminal domain | Domain | |
IPR013780 | Glycosyl hydrolase, all-beta | Homologous Superfamily | |
IPR025887 | Glycoside hydrolase family 31, N-terminal domain | Domain | |
IPR044913 | P-type trefoil domain superfamily | Homologous Superfamily | |
IPR030459 | Glycosyl hydrolases family 31, conserved site | Conserved Site | |
IPR000322 | Glycoside hydrolase family 31, TIM barrel domain | Domain | |
IPR017853 | Glycoside hydrolase superfamily | Homologous Superfamily | |
IPR000519 | P-type trefoil domain | Domain | |
IPR030458 | Glycosyl hydrolases family 31, active site | Active Site | |
IPR017957 | P-type trefoil, conserved site | Conserved Site | |
IPR011013 | Galactose mutarotase-like domain superfamily | Homologous Superfamily |
Pharos: Disease Associations Pharos Homepage Annotation
Chains | Drug Target   | Associated Disease |
---|---|---|
O43451 | : 
Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage
Chains | Enzyme Name | Description | Catalytic Residues |
---|---|---|---|
α‑glucosidase maltase-glucoamylase M-CSA #976 | α‑Glucosidase Maltase- Glucoamylase catalyses the digestion of starch. α‑Glucosidase inhibitors have been efficient in delaying glucose production, which is crucial for regulating postprandial blood glucose levels and can be used for therapeutic purposes to reduce the damage and complications in diabetics and obesity. | Defined by 10 residues: TYR:A-214ASP:A-327ASP:A-366TRP:A-406ASP:A-443MET:A-444ARG:A-526TRP:A-539ASP:A-542HIS:A-600 | EC: 3.2.1 (PDB Primary Data) EC: 3.2.1.20 (UniProt) |