2QMU

Structure of an archaeal heterotrimeric initiation factor 2 reveals a nucleotide state between the GTP and the GDP states

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2qmua1	All beta proteins	Reductase/isomerase/elongation factor common domain	Translation proteins	Elongation factors	Initiation factor eIF2 gamma subunit, domain II	(Saccharolobus solfataricus P2 ) [TaxId: 273057 ],	SCOPe (2.08)
A	d2qmua2	All beta proteins	Elongation factor/aminomethyltransferase common domain	EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	Initiation factor eIF2 gamma subunit	(Saccharolobus solfataricus P2 ) [TaxId: 273057 ],	SCOPe (2.08)
A	d2qmua3	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	G proteins	Initiation factor eIF2 gamma subunit, N-terminal (G) domain	(Saccharolobus solfataricus P2 ) [TaxId: 273057 ],	SCOPe (2.08)
B	d2qmub1	Alpha and beta proteins (a+b)	Ferredoxin-like	eIF-2-alpha, C-terminal domain	eIF-2-alpha, C-terminal domain	eIF-2-alpha, C-terminal domain	(Saccharolobus solfataricus P2 ) [TaxId: 273057 ],	SCOPe (2.08)
B	d2qmub2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Saccharolobus solfataricus P2 ) [TaxId: 273057 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	EF-Tu post-G domain-like	8056815	3002024	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	EF-Tu post-G domain-like	8056817	3002024	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Ras-like P-loop GTPases	8056814	3002022	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	eIF-2-alpha, C-terminal domain	8036122	3001618	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	GTP_EFTU_D2_2	e2qmuA4	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: GTP_EFTU_D2_2	ECOD (1.6)
A	eIF2_C	e2qmuA2	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Aminomethyltransferase beta-barrel domain	F: eIF2_C	ECOD (1.6)
A	MnmE_helical_2nd	e2qmuA3	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: MnmE_helical_2nd	ECOD (1.6)
A	DUF35_N_like	e2qmuA1	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: DUF35_N_like	ECOD (1.6)
B	EIF_2_alpha_C_1	e2qmuB1	A: a+b two layers	X: Alpha-beta plaits	H: eIF-2-alpha, C-terminal domain (From Topology)	T: eIF-2-alpha, C-terminal domain	F: EIF_2_alpha_C_1	ECOD (1.6)
C	eIF-5_eIF-2B_N	e2qmuC1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: eIF-5_eIF-2B_N	ECOD (1.6)
C	eIF-5_eIF-2B_C	e2qmuC2	A: few secondary structure elements	X: Rubredoxin-like	H: Zinc-binding domain of translation initiation factor 2 beta (From Topology)	T: Zinc-binding domain of translation initiation factor 2 beta	F: eIF-5_eIF-2B_C	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
A	2.40.30.10	Mainly Beta	Beta Barrel	Elongation Factor Tu (Ef-tu)	domain 3	CATH (4.3.0)
B	3.30.70.1130	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	EIF_2_alpha	CATH (4.3.0)
C	3.30.30.170	Alpha Beta	2-Layer Sandwich	Defensin A-like		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00009	Elongation factor Tu GTP binding domain (GTP_EFTU)	Elongation factor Tu GTP binding domain	This domain contains a P-loop motif, also found in several other families such as Pfam:PF00071, Pfam:PF00025 and Pfam:PF00063. Elongation factor Tu consists of three structural domains, this plus two C-terminal beta barrel domains.	Domain
A	PF09173	Initiation factor eIF2 gamma, C terminal (eIF2_C)	Initiation factor eIF2 gamma, C terminal	Members of this family, which are found in the initiation factors eIF2 and EF-Tu, adopt a structure consisting of a beta barrel with Greek key topology. They are required for formation of the ternary complex with GTP and initiator tRNA [1].	Domain
B	PF07541	Eukaryotic translation initiation factor 2 alpha subunit (EIF_2_alpha)	Eukaryotic translation initiation factor 2 alpha subunit	-	Family
C	PF01873	Domain found in IF2B/IF5 (eIF-5_eIF-2B)	Domain found in IF2B/IF5	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Translation initiation factor 2 gamma subunit	translation regulator activity binding organic cyclic compound binding translation regulator activity, nucleic acid binding nucleic acid binding translation initiation factor activity translation factor activity, RNA binding translation elongation factor activity RNA binding tRNA binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding translation regulator activity binding organic cyclic compound binding translation regulator activity, nucleic acid binding nucleic acid binding translation initiation factor activity translation factor activity, RNA binding translation elongation factor activity RNA binding tRNA binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding cation binding metal ion binding pyrophosphatase activity GTPase activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity	ribonucleoprotein complex biogenesis cellular biosynthetic process protein-RNA complex assembly cellular component organization cellular component biogenesis protein-RNA complex organization cellular component assembly protein-containing complex assembly translational initiation cellular component organization or biogenesis protein metabolic process formation of translation preinitiation complex protein-containing complex organization cellular metabolic process ribonucleoprotein complex biogenesis cellular biosynthetic process protein-RNA complex assembly cellular component organization cellular component biogenesis protein-RNA complex organization cellular component assembly protein-containing complex assembly translational initiation cellular component organization or biogenesis protein metabolic process formation of translation preinitiation complex protein-containing complex organization cellular metabolic process primary metabolic process translation gene expression macromolecule biosynthetic process biosynthetic process cytoplasmic translation cellular process cytoplasmic translational initiation metabolic process macromolecule metabolic process	-
B	Translation initiation factor 2 alpha subunit	translation regulator activity binding organic cyclic compound binding translation regulator activity, nucleic acid binding nucleic acid binding translation initiation factor activity translation factor activity, RNA binding RNA binding ribonucleoprotein complex binding protein-containing complex binding ribosome binding	cellular biosynthetic process cellular metabolic process primary metabolic process translation gene expression macromolecule biosynthetic process biosynthetic process translational initiation metabolic process cellular process protein metabolic process macromolecule metabolic process	-
C	Translation initiation factor 2 beta subunit	translation regulator activity binding organic cyclic compound binding translation regulator activity, nucleic acid binding nucleic acid binding translation initiation factor activity translation factor activity, RNA binding	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR005225	Small GTP-binding domain	Domain
A	IPR022424	Translation initiation factor 2, gamma subunit	Family
A	IPR000795	Translational (tr)-type GTP-binding domain	Domain
A	IPR009001	Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal	Homologous Superfamily
A	IPR050543	Eukaryotic Initiation Factor 2 Gamma Subunit	Family
A	IPR044128	Initiation factor eIF2 gamma, GTP-binding domain	Domain
A	IPR015256	Initiation factor eIF2 gamma, C-terminal	Domain
A	IPR009000	Translation protein, beta-barrel domain superfamily	Homologous Superfamily
A	IPR044127	Initiation factor eIF2 gamma, domain 2	Domain
A	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
B	IPR003029	S1 domain	Domain
B	IPR044126	IF2a, S1-like domain	Domain
B	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
B	IPR024055	Translation initiation factor 2, alpha subunit, C-terminal	Homologous Superfamily
B	IPR024054	Translation initiation factor 2, alpha subunit, middle domain superfamily	Homologous Superfamily
B	IPR011488	Translation initiation factor 2, alpha subunit	Family
B	IPR022964	Translation initiation factor 2, alpha subunit, archaeal	Family
C	IPR016190	Translation initiation factor IF2/IF5, zinc-binding	Homologous Superfamily
C	IPR002735	Translation initiation factor IF2/IF5 domain	Domain
C	IPR016189	Translation initiation factor IF2/IF5, N-terminal	Homologous Superfamily
C	IPR004458	Translation initiation factor 2, beta subunit	Family
C	IPR045196	Translation initiation factor IF2/IF5	Family