2QV2
A role of the Lowe syndrome protein OCRL in early steps of the endocytic pathway
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | ASH | e2qv2A2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: ASH | ECOD (1.6) |
A | RhoGAP | e2qv2A3 | A: alpha bundles | X: GTPase activation domain, GAP (From Topology) | H: GTPase activation domain, GAP (From Topology) | T: GTPase activation domain, GAP | F: RhoGAP | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A | 2.60.40.10 | Mainly Beta | Sandwich | Immunoglobulin-like | Immunoglobulins | CATH (4.3.0) |
A | 1.10.555.10 | Mainly Alpha | Orthogonal Bundle | Phosphatidylinositol 3-kinase | Chain A | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF00620 | RhoGAP domain (RhoGAP) | RhoGAP domain | GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR037793 | OCRL1/INPP5B, INPP5c domain | Domain | |
IPR037787 | OCRL1, PH domain | Domain | |
IPR031995 | Inositol polyphosphate 5-phosphatase, clathrin binding domain | Domain | |
IPR048869 | OCRL-1/2, ASH domain | Domain | |
IPR008936 | Rho GTPase activation protein | Homologous Superfamily | |
IPR000198 | Rho GTPase-activating protein domain | Domain | |
IPR000300 | Inositol polyphosphate-related phosphatase | Domain | |
IPR047078 | Inositol polyphosphate 5-phosphatase OCRL, RhoGAP | Domain | |
IPR046985 | Inositol 5-phosphatase | Family | |
IPR013783 | Immunoglobulin-like fold | Homologous Superfamily | |
IPR036691 | Endonuclease/exonuclease/phosphatase superfamily | Homologous Superfamily |
Pharos: Disease Associations Pharos Homepage Annotation
Chains | Drug Target   | Associated Disease |
---|---|---|
Q01968 | :