Annotations: 2V8S

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B [auth V]	SCOP2 Family	t-snare proteins	8067987	4000986	SCOP2 (2022-06-29)
B [auth V]	SCOP2 Superfamily	t-snare proteins	8067988	3000366	SCOP2 (2022-06-29)
A [auth E]	SCOP2B Superfamily	ENTH/VHS domain-like	8067880	3000164	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B [auth V]	V-SNARE	e2v8sV1	A: alpha bundles	X: STAT-like	H: t-snare proteins (From Topology)	T: t-snare proteins	F: V-SNARE	ECOD (1.6)
A [auth E]	ENTH	e2v8sE1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: ENTH	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B [auth V]	1.20.58.400	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
A [auth E]	1.25.40.90	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B [auth V]	PF05008	Vesicle transport v-SNARE protein N-terminus (V-SNARE)	Vesicle transport v-SNARE protein N-terminus	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B [auth V]	VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1B	molecular function inhibitor activity chloride channel inhibitor activity channel regulator activity transporter inhibitor activity ion channel regulator activity ion channel inhibitor activity molecular function regulator activity transporter regulator activity channel inhibitor activity chloride channel regulator activity SNAP receptor activity protein-macromolecule adaptor activity molecular adaptor activity protein binding molecular function inhibitor activity chloride channel inhibitor activity channel regulator activity transporter inhibitor activity ion channel regulator activity ion channel inhibitor activity molecular function regulator activity transporter regulator activity channel inhibitor activity chloride channel regulator activity SNAP receptor activity protein-macromolecule adaptor activity molecular adaptor activity protein binding binding SNARE binding	membrane organization cellular component organization membrane fusion cellular process cellular component organization or biogenesis cellular localization post-Golgi vesicle-mediated transport transport intracellular transport establishment of localization vesicle-mediated transport Golgi to vacuole transport localization establishment of localization in cell membrane organization cellular component organization membrane fusion cellular process cellular component organization or biogenesis cellular localization post-Golgi vesicle-mediated transport transport intracellular transport establishment of localization vesicle-mediated transport Golgi to vacuole transport localization establishment of localization in cell vacuolar transport Golgi vesicle transport secretion export from cell membrane docking organelle localization by membrane tethering secretion by cell exocytosis organelle localization vesicle docking exocytic process vesicle docking involved in exocytosis intra-Golgi vesicle-mediated transport protein localization establishment of protein localization nitrogen compound transport protein transport cellular macromolecule localization macromolecule localization intracellular protein transport cellular catabolic process catabolic process macroautophagy cellular metabolic process autophagy metabolic process process utilizing autophagic mechanism endosomal transport cytosolic transport retrograde transport, endosome to Golgi regulation of localization regulation of biological process protein localization to cell periphery regulation of cellular process regulation of protein localization protein localization to plasma membrane biological regulation localization within membrane regulation of protein localization to cell periphery protein localization to membrane regulation of cellular localization regulation of protein localization to plasma membrane regulation of protein localization to membrane organelle membrane fusion vesicle organization organelle fusion organelle organization vesicle fusion with Golgi apparatus vesicle fusion Golgi organization endomembrane system organization	membrane-bounded organelle organelle cellular anatomical entity vesicle intracellular anatomical structure cytoplasm cytosol SNARE complex protein-containing complex membrane membrane protein complex intracellular organelle intracellular membrane-bounded organelle endosome membrane membrane-bounded organelle organelle cellular anatomical entity vesicle intracellular anatomical structure cytoplasm cytosol SNARE complex protein-containing complex membrane membrane protein complex intracellular organelle intracellular membrane-bounded organelle endosome membrane endosome intracellular vesicle late endosome membrane endomembrane system cytoplasmic vesicle membrane bounding membrane of organelle cytoplasmic vesicle vesicle membrane late endosome organelle membrane organelle subcompartment endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum endoplasmic reticulum membrane recycling endosome recycling endosome membrane vacuolar membrane lytic vacuole vacuole lytic vacuole membrane lysosomal membrane lysosome Golgi apparatus extracellular region early endosome early endosome membrane perinuclear region of cytoplasm vesicle lumen membrane-enclosed lumen cytoplasmic vesicle lumen secretory granule lumen intracellular organelle lumen organelle lumen secretory granule secretory vesicle platelet alpha granule platelet alpha granule lumen somatodendritic compartment cell body neuronal cell body transport vesicle transport vesicle membrane coated vesicle membrane COPII-coated ER to Golgi transport vesicle ER to Golgi transport vesicle membrane coated vesicle synapse presynapse synaptic vesicle cell junction exocytic vesicle
A [auth E]	CLATHRIN INTERACTOR 1	clathrin binding protein binding binding cell adhesion molecule binding cadherin binding phospholipid binding lipid binding	clathrin coat assembly cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis localization import into cell transport endocytosis establishment of localization vesicle-mediated transport	membrane cellular anatomical entity membrane-bounded organelle intracellular organelle intracellular anatomical structure Golgi apparatus organelle cytoplasm intracellular membrane-bounded organelle endomembrane system endosome intracellular vesicle cytoplasmic vesicle vesicle membrane cellular anatomical entity membrane-bounded organelle intracellular organelle intracellular anatomical structure Golgi apparatus organelle cytoplasm intracellular membrane-bounded organelle endomembrane system endosome intracellular vesicle cytoplasmic vesicle vesicle cytosol perinuclear region of cytoplasm cell periphery plasma membrane protein-containing complex vesicle coat membrane protein complex membrane coat bounding membrane of organelle vesicle membrane clathrin-coated vesicle clathrin vesicle coat coated vesicle clathrin-coated vesicle membrane coated membrane clathrin coat coated vesicle membrane cytoplasmic vesicle membrane organelle membrane nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B [auth V]	IPR038407	Vesicle transport v-SNARE, N-terminal domain superfamily	Homologous Superfamily
B [auth V]	IPR000727	Target SNARE coiled-coil homology domain	Domain
B [auth V]	IPR007705	Vesicle transport v-SNARE, N-terminal	Domain
B [auth V]	IPR010989	SNARE	Homologous Superfamily
A [auth E]	IPR008942	ENTH/VHS	Homologous Superfamily
A [auth E]	IPR013809	ENTH domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B [auth V]	Pharos: Q9UEU0	astrocytic tumor glioblastoma malignant colon neoplasm ovarian cancer atypical teratoid rhabdoid tumor invasive ductal breast carcinoma malignant glioma pancreatic ductal adenocarcinoma ductal breast carcinoma in situ large cell medulloblastoma medulloblastoma pancreatic intraductal papillary-mucinous neoplasm
A [auth E]	Pharos: Q14677	atypical teratoid rhabdoid tumor glioblastoma lymphoplasmacytic lymphoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia sinusitis breast cancer large cell medulloblastoma malignant ependymoma ovarian cancer plasma cell myeloma cystic fibrosis lung adenocarcinoma malignant glioma pancreatic intraductal papillary-mucinous neoplasm atypical teratoid rhabdoid tumor glioblastoma lymphoplasmacytic lymphoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia sinusitis breast cancer large cell medulloblastoma malignant ependymoma ovarian cancer plasma cell myeloma cystic fibrosis lung adenocarcinoma malignant glioma pancreatic intraductal papillary-mucinous neoplasm psoriasis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.