Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad2vgfa1 All beta proteins PK beta-barrel domain-like PK beta-barrel domain-like Pyruvate kinase beta-barrel domain Pyruvate kinase (PK) HUMAN (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Ad2vgfa2 Alpha and beta proteins (a/b) TIM beta/alpha-barrel Phosphoenolpyruvate/pyruvate domain Pyruvate kinase Pyruvate kinase, N-terminal domain HUMAN (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Ad2vgfa3 Alpha and beta proteins (a/b) Pyruvate kinase C-terminal domain-like PK C-terminal domain-like Pyruvate kinase, C-terminal domain Pyruvate kinase, C-terminal domain HUMAN (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Bd2vgfb1 All beta proteins PK beta-barrel domain-like PK beta-barrel domain-like Pyruvate kinase beta-barrel domain Pyruvate kinase (PK) HUMAN (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Bd2vgfb2 Alpha and beta proteins (a/b) TIM beta/alpha-barrel Phosphoenolpyruvate/pyruvate domain Pyruvate kinase Pyruvate kinase, N-terminal domain HUMAN (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Bd2vgfb3 Alpha and beta proteins (a/b) Pyruvate kinase C-terminal domain-like PK C-terminal domain-like Pyruvate kinase, C-terminal domain Pyruvate kinase, C-terminal domain HUMAN (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Cd2vgfc1 All beta proteins PK beta-barrel domain-like PK beta-barrel domain-like Pyruvate kinase beta-barrel domain Pyruvate kinase (PK) HUMAN (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Cd2vgfc2 Alpha and beta proteins (a/b) TIM beta/alpha-barrel Phosphoenolpyruvate/pyruvate domain Pyruvate kinase Pyruvate kinase, N-terminal domain HUMAN (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Cd2vgfc3 Alpha and beta proteins (a/b) Pyruvate kinase C-terminal domain-like PK C-terminal domain-like Pyruvate kinase, C-terminal domain Pyruvate kinase, C-terminal domain HUMAN (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Dd2vgfd1 All beta proteins PK beta-barrel domain-like PK beta-barrel domain-like Pyruvate kinase beta-barrel domain Pyruvate kinase (PK) HUMAN (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Dd2vgfd2 Alpha and beta proteins (a/b) TIM beta/alpha-barrel Phosphoenolpyruvate/pyruvate domain Pyruvate kinase Pyruvate kinase, N-terminal domain HUMAN (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Dd2vgfd3 Alpha and beta proteins (a/b) Pyruvate kinase C-terminal domain-like PK C-terminal domain-like Pyruvate kinase, C-terminal domain Pyruvate kinase, C-terminal domain HUMAN (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyPhosphoenolpyruvate/pyruvate domain 8043048 3000510 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyPK C-terminal domain-like 8043050 3000442 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyPhosphoenolpyruvate/pyruvate domain 8043048 3000510 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyPK beta-barrel domain-like 8043047 3001296 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyPhosphoenolpyruvate/pyruvate domain 8043048 3000510 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyPK C-terminal domain-like 8043050 3000442 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyPhosphoenolpyruvate/pyruvate domain 8043048 3000510 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyPK C-terminal domain-like 8043050 3000442 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyPK beta-barrel domain-like 8043047 3001296 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyPhosphoenolpyruvate/pyruvate domain 8043048 3000510 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyPhosphoenolpyruvate/pyruvate domain 8043048 3000510 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyPhosphoenolpyruvate/pyruvate domain 8043048 3000510 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyPK beta-barrel domain-like 8043047 3001296 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyPK C-terminal domain-like 8043050 3000442 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyPhosphoenolpyruvate/pyruvate domain 8043048 3000510 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
APK_2nde2vgfA1 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: PK beta-barrel domain-likeF: PK_2ndECOD (1.6)
APK_1ste2vgfA2 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: PK_1stECOD (1.6)
APK_Ce2vgfA3 A: a/b three-layered sandwichesX: PK C-terminal domain-like (From Topology)H: PK C-terminal domain-like (From Topology)T: PK C-terminal domain-likeF: PK_CECOD (1.6)
BPK_2nde2vgfB1 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: PK beta-barrel domain-likeF: PK_2ndECOD (1.6)
BPK_1ste2vgfB3 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: PK_1stECOD (1.6)
BPK_Ce2vgfB2 A: a/b three-layered sandwichesX: PK C-terminal domain-like (From Topology)H: PK C-terminal domain-like (From Topology)T: PK C-terminal domain-likeF: PK_CECOD (1.6)
CPK_2nde2vgfC1 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: PK beta-barrel domain-likeF: PK_2ndECOD (1.6)
CPK_1ste2vgfC3 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: PK_1stECOD (1.6)
CPK_Ce2vgfC2 A: a/b three-layered sandwichesX: PK C-terminal domain-like (From Topology)H: PK C-terminal domain-like (From Topology)T: PK C-terminal domain-likeF: PK_CECOD (1.6)
DPK_2nde2vgfD4 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: PK beta-barrel domain-likeF: PK_2ndECOD (1.6)
DPK_1ste2vgfD2 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: PK_1stECOD (1.6)
DPK_Ce2vgfD1 A: a/b three-layered sandwichesX: PK C-terminal domain-like (From Topology)H: PK C-terminal domain-like (From Topology)T: PK C-terminal domain-likeF: PK_CECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B, C, D
PF02887Pyruvate kinase, alpha/beta domain (PK_C)Pyruvate kinase, alpha/beta domainPyruvate kinase catalyses the final step in glycolysis, the conversion of phosphoenolpyruvate to pyruvate with concomitant phosphorylation of ADP to ATP [1,2]. The structure of several pyruvate kinases from various organisms have been determined [2, ...Pyruvate kinase catalyses the final step in glycolysis, the conversion of phosphoenolpyruvate to pyruvate with concomitant phosphorylation of ADP to ATP [1,2]. The structure of several pyruvate kinases from various organisms have been determined [2, 3,4]. The protein comprises three-four domains: a small N-terminal helical domain (absent in bacterial PK), a beta/alpha barrel domain, a beta-barrel domain (inserted within the beta/alpha-barrel domain), and a 3-layer alpha/beta/alpha sandwich domain (represented in this entry). This domain is at the C-terminal of pyruvate kinases and contains the FBP (fructose 1,6-bisphosphate) binding site [2,4,5].
Domain
A, B, C, D
PF00224Pyruvate kinase, barrel domain (PK)Pyruvate kinase, barrel domainThis is the barrel domain of pyruvate kinases. This domain represents the beta/alpha barrel and the small beta-barrel domain inserted within it. The active site is found in a cleft between the two domains [1,2,3,4].Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B, C, D
PYRUVATE KINASE ISOZYMES R/L