2WNF

Crystal Structure of a Mammalian Sialyltransferase in complex with Gal-beta-1-3GalNAc-ortho-nitrophenol

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	GT fam29, sialyltransferase 1-like	8048232	4006022	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Sialyltransferase/TPK catalytic domain-like	8053225	3000683	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Glyco_transf_29	e2wnfA1	A: a/b three-layered sandwiches	X: Alpha-2,3/8-sialyltransferase CstII-related (From Topology)	H: Alpha-2,3/8-sialyltransferase CstII-related (From Topology)	T: Alpha-2,3/8-sialyltransferase CstII-related	F: Glyco_transf_29	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.90.1480.20	Alpha Beta	Alpha-Beta Complex	sialyltransferase cstii, chain A	Glycosyl transferase family 29	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00777	Glycosyltransferase family 29 (sialyltransferase) (Glyco_transf_29)	Glycosyltransferase family 29 (sialyltransferase)	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	CMP-N-ACETYLNEURAMINATE-BETA-GALACTOSAMIDE-ALPHA-2,3-SIALYLTRANSFERASE	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity glycosyltransferase activity sialyltransferase activity transferase activity catalytic activity beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase	carbohydrate derivative biosynthetic process glycoprotein biosynthetic process carbohydrate derivative metabolic process primary metabolic process glycoprotein metabolic process protein N-linked glycosylation protein glycosylation macromolecule biosynthetic process biosynthetic process glycosylation macromolecule modification macromolecule glycosylation metabolic process cellular process carbohydrate derivative biosynthetic process glycoprotein biosynthetic process carbohydrate derivative metabolic process primary metabolic process glycoprotein metabolic process protein N-linked glycosylation protein glycosylation macromolecule biosynthetic process biosynthetic process glycosylation macromolecule modification macromolecule glycosylation metabolic process cellular process protein metabolic process macromolecule metabolic process protein modification process oxoacid metabolic process amino sugar metabolic process carboxylic acid metabolic process small molecule metabolic process amide metabolic process organic acid metabolic process N-acetylneuraminate metabolic process sphingolipid biosynthetic process glycolipid metabolic process lipid biosynthetic process ganglioside biosynthetic process ceramide metabolic process membrane lipid metabolic process glycosphingolipid metabolic process liposaccharide metabolic process amide biosynthetic process sphingolipid metabolic process glycolipid biosynthetic process ceramide biosynthetic process glycosphingolipid biosynthetic process ganglioside biosynthetic process via lactosylceramide membrane lipid biosynthetic process ganglioside metabolic process lipid metabolic process sialylation	membrane-bounded organelle Golgi trans cisterna intracellular anatomical structure Golgi cisterna membrane Golgi apparatus subcompartment Golgi apparatus organelle subcompartment Golgi trans cisterna membrane membrane Golgi cisterna intracellular membrane-bounded organelle endomembrane system intracellular organelle cellular anatomical structure membrane-bounded organelle Golgi trans cisterna intracellular anatomical structure Golgi cisterna membrane Golgi apparatus subcompartment Golgi apparatus organelle subcompartment Golgi trans cisterna membrane membrane Golgi cisterna intracellular membrane-bounded organelle endomembrane system intracellular organelle cellular anatomical structure organelle Golgi stack cytoplasm organelle membrane extracellular region trans-Golgi network membrane trans-Golgi network Golgi medial cisterna membrane Golgi medial cisterna

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR051757	Beta-galactoside alpha2-3 sialyltransferases	Family
A	IPR012163	Sialyltransferase	Family
A	IPR001675	Glycosyl transferase family 29	Family
A	IPR038578	GT29-like superfamiliy	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.