2WYA

CRYSTAL STRUCTURE OF HUMAN MITOCHONDRIAL 3-HYDROXY-3-METHYLGLUTARYL- COENZYME A SYNTHASE 2 (HMGCS2)

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	HMG_CoA_synt_C	e2wyaB2	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: HMG_CoA_synt_C	ECOD (1.6)
B	HMG_CoA_synt_N	e2wyaB1	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: HMG_CoA_synt_N	ECOD (1.6)
C	HMG_CoA_synt_C	e2wyaC1	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: HMG_CoA_synt_C	ECOD (1.6)
C	HMG_CoA_synt_N	e2wyaC2	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: HMG_CoA_synt_N	ECOD (1.6)
D	HMG_CoA_synt_C	e2wyaD2	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: HMG_CoA_synt_C	ECOD (1.6)
D	HMG_CoA_synt_N	e2wyaD1	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: HMG_CoA_synt_N	ECOD (1.6)
A	HMG_CoA_synt_C	e2wyaA2	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: HMG_CoA_synt_C	ECOD (1.6)
A	HMG_CoA_synt_N	e2wyaA1	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: HMG_CoA_synt_N	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.40.47.10	Alpha Beta	3-Layer(aba) Sandwich	Peroxisomal Thiolase	Chain A, domain 1	CATH (4.3.0)
C	3.40.47.10	Alpha Beta	3-Layer(aba) Sandwich	Peroxisomal Thiolase	Chain A, domain 1	CATH (4.3.0)
D	3.40.47.10	Alpha Beta	3-Layer(aba) Sandwich	Peroxisomal Thiolase	Chain A, domain 1	CATH (4.3.0)
A	3.40.47.10	Alpha Beta	3-Layer(aba) Sandwich	Peroxisomal Thiolase	Chain A, domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF08540	Hydroxymethylglutaryl-coenzyme A synthase C terminal (HMG_CoA_synt_C)	Hydroxymethylglutaryl-coenzyme A synthase C terminal	-	Domain
A, B, C, D	PF01154	Hydroxymethylglutaryl-coenzyme A synthase N terminal (HMG_CoA_synt_N)	Hydroxymethylglutaryl-coenzyme A synthase N terminal	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	HYDROXYMETHYLGLUTARYL-COA SYNTHASE, MITOCHONDRIAL	hydroxymethylglutaryl-CoA synthase activity acyltransferase activity acyltransferase activity, acyl groups converted into alkyl on transfer transferase activity catalytic activity identical protein binding protein binding binding	developmental process multicellular organism development multicellular organismal process hepaticobiliary system development gland development animal organ development anatomical structure development liver development system development response to stimulus response to chemical response to xenobiotic stimulus digestive system development tube development developmental process multicellular organism development multicellular organismal process hepaticobiliary system development gland development animal organ development anatomical structure development liver development system development response to stimulus response to chemical response to xenobiotic stimulus digestive system development tube development midgut development digestive tract development connective tissue development adipose tissue development tissue development response to ketone response to lipid response to oxygen-containing compound response to testosterone response to organic cyclic compound response to triglyceride response to hormone response to endogenous stimulus response to peptide hormone response to nitrogen compound response to glucagon respiratory tube development lung development respiratory system development response to metal ion cellular response to stimulus biological process involved in interspecies interaction between organisms response to other organism cellular response to lipopolysaccharide response to external stimulus cellular response to molecule of bacterial origin response to lipopolysaccharide cellular response to oxygen-containing compound response to biotic stimulus cellular response to biotic stimulus cellular response to chemical stimulus response to bacterium cellular response to lipid cellular process response to external biotic stimulus response to molecule of bacterial origin response to stress multicellular organismal response to stress secondary alcohol biosynthetic process small molecule biosynthetic process cholesterol biosynthetic process organic hydroxy compound metabolic process sterol metabolic process steroid metabolic process cholesterol metabolic process lipid biosynthetic process alcohol metabolic process primary metabolic process secondary alcohol metabolic process biosynthetic process sterol biosynthetic process organic hydroxy compound biosynthetic process alcohol biosynthetic process small molecule metabolic process metabolic process steroid biosynthetic process lipid metabolic process fatty acid derivative biosynthetic process generation of precursor metabolites and energy fatty acid derivative metabolic process ketone body metabolic process ketone body biosynthetic process response to monosaccharide response to carbohydrate response to abiotic stimulus response to temperature stimulus response to alcohol response to ethanol cellular response to acid chemical cellular response to amino acid stimulus response to acid chemical response to amino acid response to growth hormone response to organophosphorus response to purine-containing compound response to cAMP nucleoside phosphate metabolic process acetyl-CoA metabolic process purine-containing compound metabolic process nucleobase-containing compound metabolic process acyl-CoA metabolic process organophosphate metabolic process nucleobase-containing small molecule metabolic process phosphate-containing compound metabolic process sulfur compound metabolic process amide metabolic process thioester metabolic process phosphorus metabolic process cellular response to nitrogen compound cellular response to peptide hormone stimulus cellular response to endogenous stimulus response to insulin cellular response to insulin stimulus cellular response to hormone stimulus response to fatty acid cellular response to fatty acid response to nutrient levels response to nutrient response to prostaglandin response to prostaglandin F kidney development renal system development response to linoleic acid response to glucocorticoid cellular response to organic cyclic compound cellular response to glucocorticoid stimulus cellular response to corticosteroid stimulus response to corticosteroid response to steroid hormone cellular response to steroid hormone stimulus isoprenoid biosynthetic process terpenoid biosynthetic process phospholipid biosynthetic process farnesyl diphosphate metabolic process phospholipid metabolic process farnesyl diphosphate biosynthetic process organophosphate biosynthetic process isoprenoid biosynthetic process via mevalonate farnesyl diphosphate biosynthetic process, mevalonate pathway terpenoid metabolic process isoprenoid metabolic process response to starvation	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle membrane-enclosed lumen mitochondrial matrix intracellular organelle lumen organelle lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR010122	Hydroxymethylglutaryl-CoA synthase, eukaryotic	Family
A, B, C, D	IPR013746	Hydroxymethylglutaryl-coenzyme A synthase, C-terminal domain	Domain
A, B, C, D	IPR013528	Hydroxymethylglutaryl-coenzyme A synthase, N-terminal	Domain
A, B, C, D	IPR000590	Hydroxymethylglutaryl-coenzyme A synthase, active site	Active Site
A, B, C, D	IPR016039	Thiolase-like	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: P54868	3-hydroxy-3-methylglutaryl-CoA synthase deficiency malignant colon neoplasm Neoplasm Invasiveness pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia retinal disease colonic neoplasm diabetes mellitus interstitial cystitis nephrosclerosis pancreatic intraductal papillary-mucinous carcinoma psoriasis ulcerative colitis benign colon neoplasm coronary artery disease myocardial ischemia 3-hydroxy-3-methylglutaryl-CoA synthase deficiency malignant colon neoplasm Neoplasm Invasiveness pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia retinal disease colonic neoplasm diabetes mellitus interstitial cystitis nephrosclerosis pancreatic intraductal papillary-mucinous carcinoma psoriasis ulcerative colitis benign colon neoplasm coronary artery disease myocardial ischemia oral cavity neoplasm pancreatic intraductal papillary-mucinous neoplasm breast cancer Crohn disease intellectual disability pancreatic ductal adenocarcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.